Active plantar fibromatosis occurring under anti-TNFα therapy for spondyloarthritis

Couderc, Marion; Kémény, Jean-Louis; Lhoste, A.; Soubrier, Martin; Dubost, Jean‐Jacques

doi:10.1016/j.jbspin.2016.04.006

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…Couderc et al [28] detailed the accelerated increase in plantar nodules in two young patients who were under treatment for spondylarthrosis with anti-tumor necrosis factor-alfa, suggesting that it could play a key role in the transformation of fibroblasts in myofibroblasts.…”

Section: Clinical Presentationmentioning

confidence: 99%

Ledderhose’s Disease: An Up-to-Date Review of a Rare Non-Malignant Disorder

Tomac,

Ion,

Opriș

et al. 2023

Clinics and Practice

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Plantar fibromatosis (or Ledderhose’s disease) is a rare benign condition, difficult to treat, defined by gradual-growing nodules in the central medial part of the plantar fascia, with the possibility of sclerosis and shrinkage of the entire fascia or, rarely, contractures of the toes. From a histopathological point of view, it is linked to Dupuytren’s contracture of the hand and Peyronie’s disease of the penis, being part of a large group of fibromatoses, based on a proliferation of collagen and fibroblasts. Its etiology is still not fully understood, even though it has been associated with trauma, diabetes mellitus, use of anticonvulsants, frozen shoulder, alcohol consumption, and liver disease. Typically, ultrasound confirms the diagnosis, and magnetic resonance imaging is used for more aggressive and advanced types. Several conservative treatment techniques, such as steroid injections, verapamil, imatinib, radiation therapy, extracorporeal shock wave therapy, tamoxifen, sorafenib, mitomycin C, and collagenase, have been documented. When non-operative care fails, surgical measures may be considered, even though recurrence is expected. We attempted to provide a better understanding of this disease by covering all of the important aspects: its history, clinical and radiologic findings, diagnosis, pathophysiology features, conservative and surgical treatment, recurrence rate, and prognosis.

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Section: Clinical Presentationmentioning

confidence: 99%

Ledderhose’s Disease: An Up-to-Date Review of a Rare Non-Malignant Disorder

Tomac,

Ion,

Opriș

et al. 2023

Clinics and Practice

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“…2,11,12 In a letter to the editor in the Journal of Joint Bone Spine , 2 cases of patients developing rapidly growing plantar fibromas while undergoing anti–tumor necrosis factor α (anti-TNFα) therapy for spondyloarthritis have been reported. 13 Biopsies may be useful for differentiating fibromas from malignancies such as fibrosarcoma, synovial sarcoma, and liposarcoma as well as directing treatment. 2 Advanced imaging such magnetic resonance imaging (MRI) and ultrasound are also useful in identifying fibromas from malignancies.…”

Section: Presentationmentioning

confidence: 99%