Active nanoparticle targeting of MUC5AC ameliorates therapeutic outcome in experimental colitis

Riemann, Bernadette; Antoine, Thomas; Béduneau, Arnaud; Pellequer, Yann; Lamprecht, Alf; Moulari, Brice

doi:10.1039/d3nr05681c

Nanoscale

2024

DOI: 10.1039/d3nr05681c

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Active nanoparticle targeting of MUC5AC ameliorates therapeutic outcome in experimental colitis

Bernadette Riemann,

Thomas Antoine,

Arnaud Béduneau

et al.

Abstract: Inflammatory bowel diseases (IBDs), which include Crohn’s disease (CD) and ulcerative colitis (UC), are chronic inflammatory diseases of the gastrointestinal tract and are characterized by chronic recurrent ulceration of the...

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Natural medicines-derived carbon dots as novel oral antioxidant administration strategy for ulcerative colitis therapy

Wu,

Bai,

Zhang

et al. 2024

J Nanobiotechnol

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Background Ulcerative colitis (UC) is a chronic intestinal inflammation, resulting in a global healthcare challenge with no real specific medicine. Natural medicines are recognized as a potential clinical alternative therapy, but their applications are limited by poor solubility and low bioavailability. Results In this work, inspired by the natural medicines of ancient China, novel functional carbon dots derived from Magnetite and Medicated Leaven (MML-CDs) were synthesized by hydrothermal method, and confirmed their ultrasmall nano-size (3.2 ± 0.6 nm) and Fe doped surface structure, thereby with excellent gastrointestinal stability, remarkable capabilities in eliminating ROS, and highly biocompatibility. With no external stimuli, the oral administration of MML-CDs demonstrated obvious alleviation to UC. Further experiments pointed that MML-CDs could improve hemostasis capability, suppress inflammation reactions and oxidative stress, and up-regulate the expression of tight junction proteins. Furthermore, MML-CDs also showed well regulation in the dysbiosis of intestinal flora. Conclusion Overall, above evidence reveals that green-synthesized MML-CDs can significantly alleviate intestinal bleeding, inhibit colon inflammation, and repair colonic barrier damage, further regulating intestinal flora and intestinal inflammation microenvironment. Our findings provide an efficient oral administration of MML-CDs as a novel therapy strategy for ulcerative colitis. Graphical Abstract

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Natural medicines-derived carbon dots as novel oral antioxidant administration strategy for ulcerative colitis therapy

Wu,

Bai,

Zhang

et al. 2024

J Nanobiotechnol

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Active nanoparticle targeting of MUC5AC ameliorates therapeutic outcome in experimental colitis

Abstract: Inflammatory bowel diseases (IBDs), which include Crohn’s disease (CD) and ulcerative colitis (UC), are chronic inflammatory diseases of the gastrointestinal tract and are characterized by chronic recurrent ulceration of the...

Cited by 1 publication

References 68 publications

Natural medicines-derived carbon dots as novel oral antioxidant administration strategy for ulcerative colitis therapy

Natural medicines-derived carbon dots as novel oral antioxidant administration strategy for ulcerative colitis therapy

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