Active Methamphetamine Use is Associated with Transmitted Drug Resistance to Non-Nucleoside Reverse Transcriptase Inhibitors in Individuals with HIV Infection of Unknown Duration

Moini, Niousha; Pond, Sergei L. Kosakovsky; Pesano, Rick L.; Lie, Yolanda; Aiem, Heidi; Butler, David M.; Letendre, Scott; Mathews, W. Christopher; Smith, Davey M.

doi:10.2174/1874613600701010005

Cited by 13 publications

(14 citation statements)

References 32 publications

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“…One plausible explanation is that recent research showing reduced transmission risk among HIV-positive individuals on antiretroviral therapy (Cohen et al, 2011;Donnell et al, 2010;Grant et al, 2010) could affect risk perceptions and resulting behaviors. Although one of many possible explanations, this could be particularly important to examine in settings where substance use is high (see Kalichman et al, 2011), because substance use has been shown to negatively affect HIV treatment adherence and viral load counts (Arnsten et al, 2002;Baum et al, 2009Baum et al, , 2010Fairbairn et al, 2011;Hahn and Samet, 2010;King et al, 2009;Shacham et al, 2011;Toussi et al, 2009) as well as resistance to antiretroviral medications (Cachay et al, 2007;Colfax et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Among HIV-positive individuals, heavy alcohol use has been found to be associated with decreased cluster of differentiation 4 (CD4) cell counts or nonsuppression of HIV viral load (Baum et al, 2010;Hahn and Samet, 2010;Samet et al, 2007;Shacham et al, 2011), increased neurodegeneration or memory impairment (Fama et al, 2009(Fama et al, , 2011Persidsky et al, 2011), decreased health-related quality of life (Uphold et al, 2007), and increased mortality from various causes (Bonacini, 2011;Braithwaite et al, 2007;Katcher et al, 2010). Likewise, crystal methamphetamine use among HIV-positive individuals has been found to be associated with decreased CD4 cell counts or nonsuppression of HIV viral load (Fairbairn et al, 2011;King et al, 2009;Toussi et al, 2009), neurode-generation or memory impairment (Scott et al, 2007), and resistance to antiretroviral medications (Cachay et al, 2007;Colfax et al, 2007). Cocaine or crack-cocaine use among HIV-positive individuals has been found to be associated with decreased CD4 cell counts or nonsuppression of HIV viral load (Arnsten et al, 2002;Baum et al, 2009;Rafi e et al, 2011), increases in hypertensive renal changes (Fine et al, 2007), and coronary stenosis (Lai et al, 2008).…”

Section: H IV Continues To Disproportionately Affect Men Who Have Sexmentioning

confidence: 99%

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Risk Behaviors Among HIV-Positive Gay and Bisexual Men at Party-Oriented Vacations

Fisher

Ramchand

Bana

et al. 2013

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: This study examined substance use (intended and actual), unprotected sex, and HIV disclosure practices (disclosure and questioning) among HIV-positive men who have sex with men (MSM) at two party-oriented vacations, where substance use and sexual risk may be heightened. Method: A random sample of 489 MSM attending one of two party-oriented vacations participated in PartyIntents, a short-term longitudinal survey. Nearly half (47%) completed a follow-up assessment at the event or online for up to 2 weeks after the event. We examined rates of baseline intentions to use substances, actual substance use, and unprotected intercourse among HIV-positive men in attendance. Rates among HIV-negative men were estimated for comparison. Multiple logistic regression was used to assess the impact of illegal drug use and HIV status on unprotected anal intercourse (UAI). Results: HIV-positive attendees (17%) were signifi cantly more likely than HIV-negative attendees to use nitrite inhalants (or "poppers") (24.3% vs. 10.7%). HIVpositive attendees were also signifi cantly more likely to have insertive UAI (64.3% vs. 34.1%) and receptive UAI (68.8% vs. 22.2%). Multivariate models showed associations between HIV status and illegal drug use with UAI (for HIV status, odds ratio [OR] = 4.5, p = .001; for any illegal drug use, OR = 16.4, p < .001). There was no evidence that the infl uence of drug use moderated risk by HIV status. Rates of HIV disclosure and questioning did not differ by HIV status. Conclusions: HIV-positive men attending these events engaged in higher rates of illegal drug use and sexual risk than HIV-negative men. Prevention campaigns targeting MSM at high-risk events should include messages geared toward HIVpositive men. (J. Stud. Alcohol Drugs, 74, 158-167, 2013)

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Section: Discussionmentioning

confidence: 99%

Section: H IV Continues To Disproportionately Affect Men Who Have Sexmentioning

confidence: 99%

Risk Behaviors Among HIV-Positive Gay and Bisexual Men at Party-Oriented Vacations

Fisher

Ramchand

Bana

et al. 2013

J. Stud. Alcohol Drugs

View full text Add to dashboard Cite

show abstract

“…For example, Cachay et al reported that in newly diagnosed, ART naïve individuals, those who reported using METH within the 30 days were more likely to have transmission of drug resistant HIV-1 [37]. In another case study, Markowitz et al reported an association between METH use with infection of a multidrug resistant, dual-tropic HIV-1 that resulted in rapid progression to AIDS[38].…”

Section: Meth Use Is Associated With Worsening Of Hiv Disease Progresmentioning

confidence: 99%

The Complex Interaction Between Methamphetamine Abuse and HIV-1 Pathogenesis

Passaro

Pandhare

Qian

et al. 2015

J Neuroimmune Pharmacol

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The global HIV/AIDS pandemic has claimed the lives of an estimated 35 million people. A significant barrier for combating this global pandemic is substance use since it is associated with HIV transmission, delayed diagnosis/initiation of therapy, and poor adherence to therapy. Clinical studies also suggest a link between substance use and HIV-disease progression/AIDS-associated mortality. Methamphetamine (METH) use is one of the fastest-growing substance use problems in the world. METH use enhances high-risk sexual behaviors, therefore increases the likelihood of HIV-1 acquisition. METH use is also associated with higher viral loads, immune dysfunction, and antiretroviral resistance. Moreover, METH use has also been correlated with rapid progression to AIDS. However, direct effects of METH on HIV-1 disease progression remains poorly understood because use of METH and other illicit drugs is often associated with reduced/non adherence to ART. Nevertheless, in vitro studies demonstrate that METH increases HIV-1 replication in cell cultures and animal models. Thus, it has been proposed that METH’s potentiating effects on HIV-1 replication may in part contribute to the worsening of HIV-1 pathogenesis. However, our recent data demonstrate that METH inhibits HIV-1 replication in CD4+ T cells and challenges this paradigm. Thus, the goal of this review is to systematically examine the published literature to better understand the complex interaction between METH abuse and HIV-1 disease progression.

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“…concurrent sexual partners. [14][15][16] In studies not restricted to treatment-naïve patients, rates of drug-resistant HIV are substantially higher, Richman and colleagues 17 found that among American adults who were viremic and receiving treatment, 88% were resistant to one or more drugs.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Sexually Acquired Antiretroviral Drug Resistance in a Community Sample of HIV-Positive Men Who Have Sex with Men in New York City

Goldsamt

Clatts

Parker

et al. 2011

AIDS Patient Care and STDs

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To examine antiretroviral (ARV) drug resistance, we recruited a community sample (n = 347) of sexually active HIV-positive men who have sex with men (MSM) in New York City, each of whom completed a structured interview and donated a blood sample for HIV genotyping. Participants reported high levels of sexual activity, with 94.6% reporting at least one sexual contact in the past month, and an average of 3.13 partners during this time. Anal intercourse was common, with 70.7% reporting at least one act of insertive anal intercourse (21% of whom reported ejaculating inside their partner without a condom) and 62.1% reporting at least one act of receptive anal intercourse during this time (22.6% of whom received ejaculate without a condom). Seventeen percent reported having sex with a woman in the past year. Although 17.4% of participants reported having ever injected drugs, no association was found between injection and antiretroviral resistance. Average HIV diagnosis was 12.1 years prior to the interview, and 92.1% had taken ARV medication. Sexually transmitted infections (STIs) were widely reported, with 78% having been diagnosed with an STI since being diagnosed with HIV. A genotype was obtained for 188 (54.7%) of the samples and 44.7% revealed mutations conferring resistance to at least one ARV. Resistance to at least one ARV within a given class of medication was most common for nucleoside reverse transcriptase inhibitors (30.3%) and non-nucleoside reverse transcriptase inhibitors (27.7%) and least common for protease inhibitors (18.1%). The combination of high prevalence of antiretroviral resistance and risky sexual practices makes transmission between sex partners a likely mode of acquisition.

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Active Methamphetamine Use is Associated with Transmitted Drug Resistance to Non-Nucleoside Reverse Transcriptase Inhibitors in Individuals with HIV Infection of Unknown Duration

Cited by 13 publications

References 32 publications

Risk Behaviors Among HIV-Positive Gay and Bisexual Men at Party-Oriented Vacations

Risk Behaviors Among HIV-Positive Gay and Bisexual Men at Party-Oriented Vacations

The Complex Interaction Between Methamphetamine Abuse and HIV-1 Pathogenesis

Prevalence of Sexually Acquired Antiretroviral Drug Resistance in a Community Sample of HIV-Positive Men Who Have Sex with Men in New York City

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