Active ingredient-containing chitosan/polycaprolactone nonwoven mats: Characterizations and their functional assays

Bai, Meng–Yi; Chou, Tz-Chong; Tsai, Jie-Chang; Yang, Hui-Ching

doi:10.1016/j.msec.2012.08.034

Cited by 29 publications

(18 citation statements)

References 33 publications

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“…Figure a–e shows the optical images of the DAPI‐stained fibroblast cells attached to the PCL, SFP, PVA/SFP, PEG/SFP, and PEO/SFP nonwoven mats. PCL nonwoven mats were used as the control material for comparison, as these mats showed good fibroblast cell adhesion in our previous study . Densely attached fibroblast cells were detected on the PCL nonwoven mats and PEG/SFP and PEO/SFP mats.…”

Section: Resultsmentioning

confidence: 95%

Evaluation of a series of silk fibroin protein‐based nonwoven mats for use as an anti‐adhesion patch for wound management in robotic surgery

Wang

Bai

Hsu

et al. 2017

J Biomedical Materials Res

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A novel anti-adhesion nonwoven mat mainly composed of silk fibroin protein (SFP) was fabricated via the single-spinneret electrospinning technique. A series of SFPbased electrospun nonwoven mats containing additives of different synthetic polymer ratios, such as pure SFP, SFP/poly(vinyl alcohol) (PVA), SFP/polyethylene glycol (PEG), and SFP/ polyethylene oxide (PEO) were produced and compared. All membranes were porous and had diameters of 324.02 6 113.7, 308.86 6 74.02, 366.22 6 115.81, and 341.82 6 119.42 nm, respectively. The average pore size for each membrane was

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Section: Resultsmentioning

confidence: 95%

Evaluation of a series of silk fibroin protein‐based nonwoven mats for use as an anti‐adhesion patch for wound management in robotic surgery

Wang

Bai

Hsu

et al. 2017

J Biomedical Materials Res

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“…Polycaprolactone (PCL), a semicrystalline polyester, is an ideal biomaterial for medical applications due to its unique properties such as good histocompatibility and biodegradability, lack of antigenicity in humans, a low melting point (55–60 °C), high processability, blend compatibility and low cost [111]. In order to provide an outermost barrier to prevent infection, reduce blood loss, and stop the bleeding, Bai et al developed a chitosan/polycaprolactone (PCL) non-woven mat (CS/PCLNM) by combining an electrospinning technique and a modified drop-casting method [50]. CS/PCLNM was composed of many microfibers with a CS overlayer on top of the PCL fiber, rather than the CS-PCL blended fiber (Figure 12).…”

Section: Cs-based Composite Hemostatic Materialsmentioning

confidence: 99%

Chitosan-Based Composite Materials for Prospective Hemostatic Applications

et al. 2018

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Effective hemostasis is vital to reduce the pain and mortality of patients, and the research and development of hemostatic materials are prerequisite for effective hemostasis. Chitosan (CS), with good biodegradability, biocompatibility and non-toxicity, has been widely applied in bio-medicine, the chemical industry, the food industry and cosmetics. The excellent hemostatic properties of CS have been extensively studied. As a result, chitosan-based composite hemostatic materials have been emerging. In this review, the hemostatic mechanism of chitosan is briefly discussed, and then the progress of research on chitosan-based composite hemostatic materials with multiple forms such as films, sponges, hydrogels, particles and fibers are introduced. Finally, future perspectives of chitosan-based composite hemostatic materials are given. The objective of this review is to provide a reference for further research and development of effective hemostatic materials.

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“…The ES of blends of CS and synthetic polymer is one of the commonly seen protocols to obviate the brittleness of neat CS. Our previous study demonstrated a CS/polycaprolactone nonwoven mat (CS3/PCLNM) by combining an ES technique with a modified drop‐casting method . Unlike conventional CS‐blended nonwoven mats, this CS3/PCLNM was composed of many microfibers with a CS overlayer on top of each fiber.…”

Section: Introductionmentioning

confidence: 99%

The effect of active ingredient‐containing chitosan/polycaprolactone nonwoven mat on wound healing: In vitro and in vivo studies

Bai

Chou

Tsai

et al. 2013

J Biomedical Materials Res

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The use of an electrospun polycaprolactone (PCL) nonwoven mat that is coated with a layer of chitosan (CS) containing active ingredient [tea tree oil (TTO)] represents an effective strategy for producing functional dressings. CS-coated porous PCL nonwoven mat (CS3/PCLNM) with various concentrations of active ingredients were produced and investigated. In vitro, active ingredient-containing CS3/PCLNM is effective in inhibiting the formation of nitrite and the growth of Staphylococcus aureus. Both active ingredient TTO and CS have been proven to reach their maximum amount of releases within 24 h of contact with water-based environment. In vivo, full-thickness skin removal (1.2 cm × 1.2 cm) was performed on the back of the C57BL6/J mice in noninfected and infected animal models. Four groups of functional dressings were tested in this work including Tegderm™, PCLNM, CS3/PCLNM, and 100 μL TTO-CS3/PCLNM. After 7 days post-treatment, the bacterial levels were found to be significantly lower in both CS3/PCLNM and 100 μL TTO-CS3/PCLNM-treated groups than in the control group (81.6 ± 18.1% and 93.7 ± 9.57% of reductions in the bacterial load in the pus relative to the control group, respectively). Additionally, based on the histological analyses, the 100 μL TTO-CS3/PCLNM-treated group outperformed all other groups in wound healing.

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Active ingredient-containing chitosan/polycaprolactone nonwoven mats: Characterizations and their functional assays

Cited by 29 publications

References 33 publications

Evaluation of a series of silk fibroin protein‐based nonwoven mats for use as an anti‐adhesion patch for wound management in robotic surgery

Evaluation of a series of silk fibroin protein‐based nonwoven mats for use as an anti‐adhesion patch for wound management in robotic surgery

Chitosan-Based Composite Materials for Prospective Hemostatic Applications

The effect of active ingredient‐containing chitosan/polycaprolactone nonwoven mat on wound healing: In vitro and in vivo studies

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