Active Immunization to 17β-Estradiol and Its Effects upon the Reproductive Cycle of the Rhesus Monkey

Ferin, Michel; Dyrenfurth, Inge; Cowchock, Susan; Warren, Michelle P.; Wiele, Raymond L. Vande

doi:10.1210/endo-94-3-765

Cited by 44 publications

(15 citation statements)

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“…The sporadic rises in LH-level occur¬ ring at irregular intervals in the progesterone-immunized rats may have pro¬ vided the luteal tissue responsible for continued progesterone formation. Pro¬ longation of the reproductive cycle by passive or active immunization against oestradiol has been previously reported by Ferin et al (1974) and Schwartz et al (1975) in monkeys and by Ferin et al (1969), Hillier et al (1975 and Neill et al (1971) in rats. However, Ferin et al (1974) and Hillier et al (1975) reported that immunization with an oestradiol conjugate led to the continuous presence of cornified cells in the vaginal smear.…”

Section: Discussionmentioning

confidence: 84%

“…Pro¬ longation of the reproductive cycle by passive or active immunization against oestradiol has been previously reported by Ferin et al (1974) and Schwartz et al (1975) in monkeys and by Ferin et al (1969), Hillier et al (1975 and Neill et al (1971) in rats. However, Ferin et al (1974) and Hillier et al (1975) reported that immunization with an oestradiol conjugate led to the continuous presence of cornified cells in the vaginal smear. The pre-ovulatory discharge of LH is believed to be triggered by a rise in plasma oestrogen level, acting as a positive feedback agent (Ferin et al 1974;Knobil 1974).…”

Section: Discussionmentioning

confidence: 84%

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Endocrine and Reproductive Repercussions of Immunization Against Progesterone and Oestradiol in Female Rats

Kaushansky

Bauminger

Koch

et al. 1977

Acta Endocrinologica

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Mature female rats were immunized with BSA-conjugates of oestradiol17\g=b\-6-carboxymethyloxime or progesterone-11-hemisuccinate. Sera tested two months later at 1/2000 dilution bound 63.3 % \ m=+-\3.1 sem and 21.2% \ m=+-\ 2.3 of the homologous tritiated hormone (10 pg), -oestradiol-17\g=b\(Oe2) and progesterone (P), respectively. Rats immunized against Oe2 had a significantly longer oestrous cycle (8.2 days vs. 4.5 days in BSA-immunized rats), with a prolonged leukocytic phase. The cycle of rats immunized against P was also prolonged (10.5 days), but in this group the cornified smear phase was abnormally extended. The luteinizing hormone (LH) normally observed on the afternoon of pro-oestrus failed to occur in the rats immunized against Oe2 and in 70 % of rats immunized against P. The latter animals, however, showed sporadic LH discharges during periods of persistent cornification. Immunization against P resulted in elevated total (free plus bound) plasma P levels; immunization against Oe2 prevented the pro-oestrous rise in plasma P. Mating of rats immunized against Oe2 resulted in normal pregnancies, while none of the rats immunized against P delivered.Steroid-protein conjugates have been extensively used to generate antisera for use in radioimmunoassay procedures. Less attention has been paid to the effect of such immunization on the endocrine balance and reproductive behaviour of the immunized animal.It is believed that the pre-ovulatory surge of LH, which occurs in the rat on the afternoon of pro-oestrus, depends on oestrogen secretion (Schwartz 8c

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 84%

Endocrine and Reproductive Repercussions of Immunization Against Progesterone and Oestradiol in Female Rats

Kaushansky

Bauminger

Koch

et al. 1977

Acta Endocrinologica

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“…Immunization of ewes against oestrogens can produce a castration-like effect upon pituitary function and block or delay ovulation (Scaramuzzi et ai, 1977 ;Pant, Dobson & Ward, 1978;Rawlings, Kennedy & Henricks, 1978;Martensz, Scaramuzzi & Van Look, 1979), quickly rendering the animal anovulatory (Scaramuzzi, 1975;Cox & Wilson, 1976;Scaramuzzi et ai, 1977). The prevention of oestrus and ovulation by circulating antibodies to oestrogens has also been noted in other species (Sundaram, Tsong, Hood & Brinson, 1973;Ferin, Dyrenfurth, Cowchock, Warren & Vande Wiele, 1974;Elsaesser & Parvizi, 1977;Martin, Henricks, Hill & Rawlings, 1978;Elsaesser, 1980). Nevertheless, the increases in ovulation and lambing rates after immunization of sheep against oestrogens have been reported (Smith et ai, 1981 ;Land, Morris, Baxter, Fordyce & Forster, 1982).…”

Section: Introductionmentioning

confidence: 85%

Reproductive effects of immunizing heifers against androstenedione and oestradiol-17

Wise¹,

Schanbacher²

1983

Reproduction

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“…In mammalian species oestradiol secretion from the developing follicle is the principal factor in inducing the preovulatory surge of luteinizing hormone (LH) (Ferin et al, 1974a). This surge can be mimicked during the early follicular phase, or in ovariectomized animals, by administration of oestradiol benzoate.…”

Section: Introductionmentioning

confidence: 99%

Blockade of the oestrogen-induced LH surge in the ovariectomized common marmoset (Callithrix jacchus) by an LHRH antagonist

O’Byrne

Lunn²,

Fraser³

1989

Reproduction

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Summary. Six long-term ovariectomized adult marmoset monkeys were treated at 0 h with 35 \g=m\g oestradiol benzoate s.c. to induce an LH surge. They were also treated with detirelix (an LHRH antagonist) at 0 h, 12 h and 24 h (Exp. 1), or at 0 h and 24 h (Exp. 2) at a dose of 300 \g=m\g/kgs.c., or received the detirelix vehicle alone at 0 h, 12h and 24 h (Exp. 3). All animals received the three treatments, with at least 4 weeks between experiments. Blood samples were collected at 0 h and at 6\p=n-\12h intervals for 72 h after oestradiol for the determination of plasma LH by bioassay. In control animals, oestrogen treatment resulted in a decline in plasma LH from 30\m=.\0 \ m=+-\ 5\m=.\8at 0 h to 12\m=.\8 \ m=+-\ 2\m=.\6 ng/ml at 6 h (negative feedback), followed by a positive feedback surge, reaching a maximum of 148\m=.\0\m=+-\ 34\m=.\6ng/ml at 24h. Values then declined to pretreatment levels by 56h. In contrast, antagonist-treated animals showed complete abolition of the expected increase at 24 h, the low levels of the negative feedback phase being maintained for 36\p=n-\72h.These results show that hypothalamic LHRH release is essential during the oestrogen-induced LH surge, and that a direct oestrogen-induced component at the pituitary level is not expressed in the absence of LHRH in the marmoset.

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Active Immunization to 17β-Estradiol and Its Effects upon the Reproductive Cycle of the Rhesus Monkey

Cited by 44 publications

References 0 publications

Endocrine and Reproductive Repercussions of Immunization Against Progesterone and Oestradiol in Female Rats

Endocrine and Reproductive Repercussions of Immunization Against Progesterone and Oestradiol in Female Rats

Reproductive effects of immunizing heifers against androstenedione and oestradiol-17

Blockade of the oestrogen-induced LH surge in the ovariectomized common marmoset (Callithrix jacchus) by an LHRH antagonist

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