Active HHV-6 Infection in Chronic Fatigue Syndrome Patients from Italy

Zorzenon, M.; Rukh, Gull; Botta, Giuseppe; Colle, R; Barsanti, Laura; Ceccherini‐Nelli, Luca

doi:10.1300/j092v02n01_02

Cited by 16 publications

(7 citation statements)

References 5 publications

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“…In 1991, Landay et al found antibodies to EBV early antigen significantly more frequently among ME/CFS patients than healthy adults, but they observed equal rates of EBV VCA and EBNA seropositivity among patients and controls [ 76 ]. At the same time, other studies showed no correlation between EBV infection, nor CMV infection, and ME/CFS [ 77 , 78 ]. A very low percentage of EBV-specific IgG class antibodies in patients and controls has been described [ 79 ].…”

Section: Human Herpesvirusesmentioning

confidence: 90%

Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

et al. 2018

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Background and main textMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and controversial clinical condition without having established causative factors. Increasing numbers of cases during past decade have created awareness among patients as well as healthcare professionals. Chronic viral infection as a cause of ME/CFS has long been debated. However, lack of large studies involving well-designed patient groups and validated experimental set ups have hindered our knowledge about this disease. Moreover, recent developments regarding molecular mechanism of pathogenesis of various infectious agents cast doubts over validity of several of the past studies.ConclusionsThis review aims to compile all the studies done so far to investigate various viral agents that could be associated with ME/CFS. Furthermore, we suggest strategies to better design future studies on the role of viral infections in ME/CFS.

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Section: Human Herpesvirusesmentioning

confidence: 90%

Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

et al. 2018

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“…19 Many studies that have employed assays that can detect active infection-polymerase chain reaction (PCR) of serum or plasma, IgM early antigen antibodies, and primary cell culture-have found an association between CFS and active HHV-6 infection. 19, [148][149][150][151][152][153][154] Several other studies have not demonstrated this association. 155,156 The greater frequency of reactivated infection with HHV-6 more often in patients with CFS in comparison to healthy control volunteers does not prove an etiologic role for this virus.…”

Section: Human Herpesvirus-6mentioning

confidence: 95%

Role of Infection and Neurologic Dysfunction in Chronic Fatigue Syndrome

Komaroff

Cho²

2011

Semin Neurol

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Chronic fatiguing illnesses following well-documented infections and acute "infectious-like" illnesses of uncertain cause have been reported for many decades. Chronic fatigue syndrome (CFS) was first formally defined in 1988. There is considerable evidence that CFS is associated with abnormalities of the central and autonomic nervous systems. There also is evidence linking several infectious agents with CFS, although no agent has been proven to be a cause of the illness. Most of the infectious agents that have been linked to CFS are able to produce a persistent, often life-long, infection and thus are a constant incitement to the immune system. Most also have been shown to be neuropathogens. The evidence is consistent with the hypothesis that CFS, in some cases, can be triggered and perpetuated by several chronic infections that directly or indirectly affect the nervous system, and that symptoms are a reflection of the immune response to the infection.

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“…In contrast, other studies have employed assays that can detect active infection: PCR of serum or plasma, IgM early antigen antibodies, and primary cell culture. Most of these studies have shown an association between CFS and active HHV‐6 infection [Patnaik et al, 1995; Secchiero et al, 1995; Wagner et al, 1996; Zorzenon et al, 1996; Ablashi et al, 2000; Nicolson et al, 2003], whereas a few have not [Koelle et al, 2002; Reeves et al, 2000]. The number of patients in the studies that have found an association between CFS and active HHV‐6 infection (N = 717) is much larger than the number in studies that have failed to find an association (N = 48).…”

Section: Chronic Fatigue Syndromementioning

confidence: 99%