Active hexose correlated compound modulates LPS-induced hypotension and gut injury in rats

Doursout, Marie–Françoise; Liang, Yangyan; Sundaresan, Alamelu; Wakame, Koji; Fujii, H.; Takanari, Jun; Devakottai, Sundar; Kulkarni, Anil D.

doi:10.1016/j.intimp.2016.07.023

Cited by 6 publications

(6 citation statements)

References 33 publications

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Section: Discussionmentioning

confidence: 99%

“…Previous studies using higher doses of LPS, for eliciting the inflammatory process, demonstrated that this approach promoted a hypotensive response (Altavilla et al, 2002; Doursout et al, 2016). For instance, Dourtsout and coworkers (Doursout et al, 2016) observed a decrease in mean arterial pressure, 1 h after the administration of a high dose of LPS, in conscious rats, followed by the recover to baseline levels 2 and 3 h later. Another study evaluated the time course of the mean arterial pressure for 360 min, after LPS administration, displaying a sustained reduction of this hemodynamic parameter in anesthetized rats, over time, initiating 30 min after the injection (Altavilla et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

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Time Course of Hemodynamic Responses to Different Doses of Lipopolysaccharide in Unanesthetized Male Rats

et al. 2019

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Lipopolysaccharide (LPS) administration is a well-known method to induce systemic inflammation widely used for investigating new therapeutic strategies for sepsis treatment, which is characterized by clinical manifestations such as tachycardia and hypotension. However, there are different doses of LPS used in several studies, and the hemodynamic responses were not always well characterized. Thus, the present study aimed to evaluate the arterial pressure, heart rate, heart rate variability, and baroreflex function from rats, over time, to different doses of LPS. Femoral artery and vein catheters were inserted into anesthetized Wistar-Hannover male rats for arterial pressure recording and LPS administration, respectively. On the next day, the arterial pressure was recorded before and after (90, 180, and 360 min) LPS injection (0.06, 20, 30, and 40 mg/kg). All doses of LPS tested increased the heart rate and decreased baroreflex sensitivity over time. In addition, while LPS administration of 20, 30, and 40 mg/kg increased the mean arterial pressure over time, 0.06 mg/kg decreased the mean arterial pressure at 360 min, as compared to baseline values. Furthermore, high doses of LPS decreased the power of the HF band of the cardiac interval spectrum over time, and the higher dose increased the power of the LF band. Our data indicate that high doses of LPS promote hypertensive response over time, while a low dose decreases arterial pressure. Moreover, the changes in heart rate variability and baroreflex function elicited by LPS may be not associated with arterial pressure response produced by the endotoxemia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Time Course of Hemodynamic Responses to Different Doses of Lipopolysaccharide in Unanesthetized Male Rats

et al. 2019

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“…These results might be supported by the antioxidant and anti-inflammatory effects of AHCC. 16 - 18 , 28 - 30 These findings should be validated in a randomized trial setting.…”

Section: Discussionmentioning

confidence: 91%

“… 12 AHCC contains various nutrients including oligosaccharides, amino acids, and minerals. The effect of AHCC on the immune system for malignancy by natural killer (NK) and T cell, its usefulness in clinical cancer therapy 13 - 15 and its anti-inflammatory and anti-oxidant effects 16 - 18 have been reported. Only 1 study reported that the intake of AHCC improved the prognosis for patients with HCC who underwent curative hepatectomy.…”

Section: Introductionmentioning

confidence: 99%

Preventing Recurrence of Hepatocellular Carcinoma After Curative Hepatectomy With Active Hexose-correlated Compound Derived From Lentinula edodes Mycelia

et al. 2022

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Purpose: Active hexose-correlated compound (AHCC), a standardized extract of cultured Lentinula edodes mycelia, exerts antitumor effects through anti-inflammatory and immune-modulatory functions. Adjuvant therapy for patients with hepatocellular carcinoma (HCC) who have undergone curative hepatectomy has not been established. The purpose of this study was to evaluate the efficacy and safety of AHCC as adjuvant therapy in patients with advanced HCC after curative hepatectomy. Patients and methods: The study design was single-armed, non-randomized, open (no one was blinded), and uncontrolled. Patients with HCC who underwent curative hepatectomy were treated with AHCC (1 g) 3 times daily orally for 2 years. The inclusion criteria were HCC diagnosed preoperatively as stages A and B of the Barcelona clinic liver cancer (BCLC) classification and alpha-fetoprotein × protein induced by vitamin K absence or antagonist II (PIVKA-II) ≥ 105 for stage A. Results: A total of 29 patients were treated with AHCC, of which 25 (4 patients discontinued) were followed up. The 2-year recurrence-free survival rate after resection was 48% for those without discontinuations and 55.2% for all patients with a history of treatment. Serum albumin levels decreased to a minimum in the first postoperative month and gradually recovered to the preoperative level at 6 months. Almost no change in lymphocyte percentage was observed during follow-up. Inflammation-based prognostic scores were maintained at favorable levels after hepatectomy. Toxicity and adverse events were not observed in any patient. Conclusion: AHCC may be safe and effective in preventing HCC recurrence after curative hepatectomy, and further randomized trials of AHCC for its use in this setting are warranted. This clinical trial was registered in UMIN Clinical Trials Registry (ID UMIN000024396).

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“…We demonstrated the involvement of the AMPK‐mediated pathway with JCo extract treatment in LPS‐induced inflammation and oxidative stress (Figure 8). LPS‐induced inflammatory response is a well‐established model for studying inflammation‐induced organ damage (Doursout et al, 2016). Our data indicated that LPS induced a significant reduction in arterial blood pressure and increase in proinflammatory cytokines such as TNF‐α and IL‐lβ.…”

Section: Discussionmentioning

confidence: 99%

Juniperus communis extract ameliorates lipopolysaccharide‐induced acute kidney injury through the adenosine monophosphate–activated protein kinase pathway

Lin

Chang

et al. 2022

Food Science & Nutrition

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Sepsis refers to life-threatening organ dysfunction associated with infection. It is a leading cause of acute kidney injury (AKI) in patients with critical illness, and 60% of patients with sepsis present with AKI (Poston & Koyner, 2019;Skube et al., 2018). Injected lipopolysaccharide (LPS), a major component of the outer membrane of gram-negative bacteria, can induce sepsis and mimic the infection observed in humans (Kupferschmid et al., 2018). Following LPS injection, renal tubular epithelial cells express toll-like receptor 4 (TLR4), and the binding of the LPS to TLR4 activates the downstream signaling pathways, including the nuclear factor-κB (NF-κB) pathway; this activation triggers an inflammatory response involving increased synthesis of proinflammatory cytokines and reactive oxygen species (ROS) as well as oxidative stress, ultimately leading to multiple-organ dysfunction (Liu & Malik, 2006;(Peerapornratana et al., 2019)). However, adenosine monophosphate-activated protein kinase (AMPK) can suppress inflammation, inhibit NF-κB signaling (Salt & Palmer, 2012), and promote the activation of the antioxidant nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase (HO)-1 pathway against oxidative stress (Lei et al., 2020;Zimmermann et al., 2015).

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Active hexose correlated compound modulates LPS-induced hypotension and gut injury in rats

Cited by 6 publications

References 33 publications

Time Course of Hemodynamic Responses to Different Doses of Lipopolysaccharide in Unanesthetized Male Rats

Time Course of Hemodynamic Responses to Different Doses of Lipopolysaccharide in Unanesthetized Male Rats

Preventing Recurrence of Hepatocellular Carcinoma After Curative Hepatectomy With Active Hexose-correlated Compound Derived From Lentinula edodes Mycelia

Juniperus communis extract ameliorates lipopolysaccharide‐induced acute kidney injury through the adenosine monophosphate–activated protein kinase pathway

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