Active Hair Growth (Anagen) is Associated with Angiogenesis

Mecklenburg, Lars; Tobin, Desmond J.; Müller-Röver, Sven; Handjiski, Bori; Wendt, Gunnar.; Peters, Eva M.J.; Pohl, Susanne; Moll, Ingrid; Paus, Ralf

doi:10.1046/j.1523-1747.2000.00954.x

Cited by 227 publications

(198 citation statements)

References 58 publications

Supporting

Mentioning

184

Contrasting

Unclassified

Order By: Relevance

“…A reduced vasculature around hair follicle is related to decreased synthesis of VEGF [32,33]. Interestingly enough, HGF and IGF-1 exert stimulatory effect on VEGF expression.…”

Section: Discussionmentioning

confidence: 98%

“…Hair follicle angiogenesis is a complex process controlled by both proangiogenic and antiangiogenic factors [31][32][33]. Among different mediators under special interest are: VEGF-A, HGF, IGF-1.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly enough, HGF and IGF-1 exert stimulatory effect on VEGF expression. Therefore, it may be expected that these factors may be also involved in anagen-associated angiogenesis [33,34]. In the group of antiangiogenic factors endostatin deserves special attention.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Capillaroscopic patterns in patients with systemic sclerosis, psoriasis and alopecia and their correlations with serum concentrations of several angiogenic markers

Chodorowska

Michalska-Jakubus

Bartosińska

et al. 2015

Polish Journal of Public Health

View full text Add to dashboard Cite

Introduction. Capillaroscopy is a non-invasive imaging method that allows cutaneous microcirculation to be analyzed. During the last decades, a diagnostic and prognostic potential of nailfold capillaroscopy (NVC) has been gaining increasing appreciation. The main indications include Raynaud phenomenon and scleroderma spectrum diseases, however the usefulness of this technique is also suggested in a variety of non-rheumatic diseases.Aim. To assess capillaroscopic patterns in systemic scleroderma (SSc), psoriasis (PV), psoriatic arthritis (PsA), alopecia areata (AA) and androgenetic alopecia. To evaluate serum levels of several endothelial and angiogenic markers, and their relation to capillaroscopic pattern.Material and methods. There were evaluated 295 patients with systemic scleroderma (SSc), psoriasis (PV), psoriatic arthritis (PsA), alopecia areata (AA) and androgenetic alopecia, as well as age-and sex-matched controls, were examined. In each subject, NVC was performed and serum concentration levels of several angiogenic markers.Results. In SSc three NVC patterns: early, active and late were distinguished. Angiopoietin-2 concentrations were higher and andothelial microparticles were lower in patients with late NVC pattern. We found several differences between the NVC pattern in PV and PsA. No correlations between NVC pattern and serum levels of angiogenic markers were revealed. In AA, we distinguished both normal and abnormal NVC patterns, although the normal patterns were more frequent. Branching capillaries and features of neoformation were often present in patients with the abnormal pattern. In androgenetic alopecia, the normal NVC pattern was most frequently present, however, we found several statistically significant capillarosopic alterations, like branching capillaries, features of neoformation and altered distribution of capillaries.Discussion and Conclusions. Serum levels of Ang-2 and EMPs may reflect capillary damage in SSc. NVC pattern varies between PV and PsA patients. The presence of abnormal NVC patterns in alopecia patients might show the role of disturbances in microcirculation in the diseases. Further studies are required to confirm the hypothesis.

show abstract

“…A reduced vasculature around hair follicle is related to decreased synthesis of VEGF [32,33]. Interestingly enough, HGF and IGF-1 exert stimulatory effect on VEGF expression.…”

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Capillaroscopic patterns in patients with systemic sclerosis, psoriasis and alopecia and their correlations with serum concentrations of several angiogenic markers

Chodorowska

Michalska-Jakubus

Bartosińska

et al. 2015

Polish Journal of Public Health

View full text Add to dashboard Cite

show abstract

“…The DP determines the size of the anagen hair bulb, the duration of anagen and hair shaft diameter [20,29,30]. In adult hair, DP maintains the vascular system that provides the nutritional support and hormonal regulation required for hair growth [31].…”

Section: Hair Follicle Anatomymentioning

confidence: 99%

Biology of Human Hair: Know Your Hair to Control It

Araújo

Fernandes

Cavaco‐Paulo

et al. 2010

Biofunctionalization of Polymers and Their Applications

View full text Add to dashboard Cite

Hair can be engineered at different levels-its structure and surfacethrough modification of its constituent molecules, in particular proteins, but also the hair follicle (HF) can be genetically altered, in particular with the advent of siRNA-based applications. General aspects of hair biology are reviewed, as well as the most recent contributions to understanding hair pigmentation and the regulation of hair development. Focus will also be placed on the techniques developed specifically for delivering compounds of varying chemical nature to the HF, indicating methods for genetic/biochemical modulation of HF components for the treatment of hair diseases. Finally, hair fiber structure and chemical characteristics will be discussed as targets for keratin surface functionalization.

show abstract

“…Cell nuclei were counterstained with 4,6-diamidino-2-phenylindole. 47 For double-immunofluorescence detection of MHC II-and CD11c-positive cells application of protocols was combined. Slides were examined using a Zeiss Axioscope light microscope and a Zeiss Axioscope fluorescence microscope (Zeiss, Oberkochen, Germany).…”

Section: Immunohistochemistry For Mhc II Icam-1 Langerin Cd11cmentioning

confidence: 99%

Stress-Induced Neurogenic Inflammation in Murine Skin Skews Dendritic Cells Towards Maturation and Migration

Joachim

Handjiski

Blois

et al. 2008

The American Journal of Pathology

View full text Add to dashboard Cite

The skin continuously serves as a biosensor of multiple exogenous stressors and integrates the resulting responses with an individual's central and peripheral endogenous response systems to perceived stress; it also acts to protect against external challenges such as wounding and infection. We have previously shown in mice that stress induces nerve growth factor-and substance P-dependent neurogenic inflammation, which includes the prominent clustering of MHC class II ؉ cells. Because the contribution of dendritic cells (DCs) in response to stress is not well understood, we examined the role of DCs in neurogenic inflammation in murine skin using a well-established murine stress model. We show that sound stress increases the number of intradermal langerin Mammalian skin serves as a complex biological interface system that protects against external challenges such as wounding, infection, or UV radiation and even safeguards against viral and carcinogen-induced transformation. These complex functions only can be executed because skin represents far more than a simple mechanical barrier. It also constitutes a critical first barrier of immune defenses targeted against external stressors that crucially directs the linkage of innate and adaptive immunity. 1 Superimposed on this is the impact of psychological stress, which may challenge these complex interface functions of the skin.2 In this context, we previously introduced the existence of the brain-skin connection 3 by revealing that the skin and its appendages are not only vulnerable to key stress mediators such as Corticotropinreleasing hormone, substance P (SP), and nerve growth factor, but also are themselves potent sources of these stress response mediators. 4 -6 This-insufficiently defined-brain-skin connection provides the rationale for common skin responses to stress such as excessive Supported by the German Research Foundation (Deutsche Forschungsgemeinschaft; grants Ar 232/14-2 and Pa 345/11-2) and the Charité (UFF 99-648 and habilitation programs to R.A.J. and S.M.B.).

show abstract

Active Hair Growth (Anagen) is Associated with Angiogenesis

Cited by 227 publications

References 58 publications

Capillaroscopic patterns in patients with systemic sclerosis, psoriasis and alopecia and their correlations with serum concentrations of several angiogenic markers

Capillaroscopic patterns in patients with systemic sclerosis, psoriasis and alopecia and their correlations with serum concentrations of several angiogenic markers

Biology of Human Hair: Know Your Hair to Control It

Stress-Induced Neurogenic Inflammation in Murine Skin Skews Dendritic Cells Towards Maturation and Migration

Contact Info

Product

Resources

About