Active compound profiling in fraction 49 of a secondary metabolite extract from Streptomyces hygroscopicus subsp. Hygroscopicus as antimalaria drug using LCMS, molecular docking, and molecular dynamics
Sawitri Aji Ardiyanti,
Afifah Aulia Farahdina,
Loeki Enggar Fitri
et al.
Abstract:Background Antimalarial resistance in Indonesia is caused by mutations at the drug target sites and biochemical changes in drug receptors. Previous research indicates that only fraction 49 of Streptomyces hygroscopicus Subsp. Hygroscopicus (S. hygroscopicus) is effective as an antimalarial agent in in vitro tests.Methods The active compounds of secondary metabolites from S. hygroscopicus were identified using LCMS. The binding of compounds to target proteins (PfK13, PfPM2, and PfAMA-1) underwent molecular dyna… Show more
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