Active Chronic Pulmonary Histoplasmosis

Sutliff, W. D.; Hughes, Felix A.; Ulrich, Elizabeth; Burkett, Luther L.

doi:10.1001/archinte.1953.00240220119015

Cited by 34 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ln sorne cases of this type of histoplasmosis, the patients have been cured by pulmonary resection. 12 Treatment with MRD-ll2 apparently does not have any effect on the old fibrocaseous cavitary lesions. However, since streptomycin and isoniazid have little effect on similar lesions in cases of reinfection tuberculosis, the effect of MRD-ll2 must be evaluated in cases of acute disseminated histoplasmosis.…”

Section: Hiatoplaamosiamentioning

confidence: 94%

Therapy for Pulmonary and Systemic Fungus Diseases

Smith

1956

Postgraduate Medicine

View full text Add to dashboard Cite

Section: Hiatoplaamosiamentioning

confidence: 94%

Therapy for Pulmonary and Systemic Fungus Diseases

Smith

1956

Postgraduate Medicine

View full text Add to dashboard Cite

“…At the periphery of the lesions there was a thin and incomplete rim of fibrous tissue, and diffuse infiltration of the alveoli by macrophages. Doubly refractile ovoid bodies [2][3][4] ,um in diameter were present in macrophages and giant cells (fig 2). In addition, large numbers of these bodies were present outside cells in necrotic areas.…”

Section: Pathological Findingsmentioning

confidence: 99%

Chronic pulmonary histoplasmosis in an irishman.

Madden¹,

Kennedy²,

Hitchcock³

et al. 1981

Thorax

View full text Add to dashboard Cite

We present the case history of a 48-year-old Irish engineer who developed active pulmonary histoplasmosis. He presented with mild symptoms and a markedly abnormal chest radiograph five years after his return from areas where histoplasmosis is endemic. The determinants of the factors initiating activation of disease and the explanation for the period of dormancy of infection remain speculative. Case reportThe patient, a 48-year-old Irish engineer, was admitted to hospital on 6 December 1978. He complained of dry cough and intermittent sweating for six weeks. There were no other symptoms. He stopped smoking cigarettes six years before admission and was a pipe smoker until this illness. A considerable portion of his life had been spent in the tropics. In 1945-50 he was in Malaya for 12 months; in 1957-58 he was in Nigeria for 12 months; in 1958-59 he was in Senegal for nine months; in 1959-60 he was in Malta for nine months; in 1969-70 he was in Zambia. In 1973 he returned to Ireland and has lived here since.On examination he was a fit looking man. There was no lymphadenopathy. Blood pressure was 130/90. A soft systolic murmur at the lower left sternal edge was noted. The lungs were clinically clear. He had normal breath sounds over both lungs and no added sounds. The abdomen, genitalia and nervous system were normal on examination. Chest radiography showed multiple discrete opacities in both mid and lower zones (fig 1). The erythrocyte sedimentation rate was 63 mm in one hour. The Mantoux test was positive. Pulmonary function tests showed a mild restrictive defect. Peripheral lung biopsy showed interstitial fibrosis. Other investigations including full blood count, urea and electrolytes, electrocardiograph, intravenous pyelogram, liver biopsy, and bronchoscopic appearances were normal. A left basal segmentectomy was carried out on 18 December 1978. PATHOLOGICAL FINDINGSThe segment of lung weighed 220 g and contained several circumscribed masses of firm white tissue, similar on gross examination to metastatic tumour tissue. The largest mass situated in the left anterior basal segment measured 5 cm in maximal dimensions. Absence of

show abstract

“…case7). Diffuse miliary pneumonitis of both lung fields with bilateral perihilar infiltration, more marked on the right.…”

mentioning

confidence: 93%