Active case finding and treatment adherence in risk groups in the tuberculosis pre-elimination era

Abstract

Vulnerable populations, including homeless persons, high-risk drug and alcohol users, prison inmates and other marginalised populations, contribute a disproportionate burden of tuberculosis (TB) cases in low-incidence settings. Drivers of this disease burden include an increased risk of both TB transmission in congregate settings, and progression from infection to active disease. Late diagnosis and poor treatment completion further propagate the epidemic and fuel the acquisition of drug resistance. These groups are therefore a major priority for TB control programmes in low-incidence settings. Targeted strategies include active case finding (ACF) initiatives and interventions to improve treatment completion, both of which should be tailored to local populations. ACF usually deploys mobile X-ray unit screening, which allows sensitive, high-throughput screening with immediate availability of results. Such initiatives have been found to be effective and cost-effective, and associated with reductions in proxy measures of transmission in hard-to-reach groups. The addition of point-of-care molecular diagnostics and automated X-ray readers may further streamline the screening pathway. There is little evidence to support interventions to improve adherence among these risk groups. Such approaches include enhanced case management and directly observed treatment, while video-observed therapy (currently under evaluation) appears to be a promising tool for the future. Integrating outreach services to include both case detection and case-management interventions that share a resource infrastructure may allow cost-effectiveness to be maximised. Integrating screening and treatment for other diseases that are prevalent among targeted risk groups into TB outreach interventions may further improve cost-effectiveness. This article reviews the existing literature, and highlights priorities for further research.

Active versus passive case finding for tuberculosis in marginalised and vulnerable populations in India: comparison of treatment outcomes

“…There is little evidence to support interventions to improve adherence among people with ACF-diagnosed TB from marginalised and vulnerable populations. These risk groups could have additional predictors of unfavourable outcomes [28].…”

Tuberculosis active case-finding interventions and approaches for prisoners in sub-Saharan Africa: a systematic scoping review

“…Tuberculosis (TB) is a major global health problem. TB affects about 30% of the world's population and is the topmost cause of mortality from a sole infectious agent accounting for more than 1.3 million deaths yearly [1][2][3][4]. It is estimated that appropriately 94% of all TB infections and deaths occur in low-and-middle-income countries, including Sub-Saharan Africa (SSA) [4].…”

The cost-effectiveness of an HCV outreach intervention for at-risk populations in London, UK

“…Among these groups, travel for accessing treatment can be expensive and impractical, whilst mistrust in the health system and difficulty in navigating hospital-based care pathways are significant barriers to engaging in care 8 , 9 . Emerging evidence focused on TB (which affects similar groups) suggests that community- and primary care-based models of treatment are effective in locating and engaging vulnerable groups through bringing health services to them that are responsive to their needs 10 , 11 . Whilst there has been increased HCV testing in community settings in the UK, and an increase in community treatment clinics, linkage to care remains an issue.…”