Active and inactive renin after exercise

Abstract

The effects of graded exercise on plasma concentrations of active and inactive renin were studied in seven healthy men. Exercise was performed on a cycle ergometer at four different exercise intensities (corresponding to 30%, 50%, 80% and 87% of VO2max) for 10 min each. Concentrations of active renin and total renin after activation by trypsin were measured by direct immunoradiometric assay. Non-trypsin-activated renin concentration (inactive) was obtained by subtraction. Active renin concentrations at 30%, 50%, 80% and 87% of VO2max were 1.2, 1.9, 3.1 and 4.6 times higher than the control concentration, respectively. Similar increases in plasma renin concentration, determined by conventional enzymatic assay, were observed at every stage. In contrast, changes in inactive renin concentration were not significant at any stage. Significant increases in noradrenaline concentration were found at every exercise stage, but adrenaline, aldosterone and lactate concentrations were significantly elevated only after exercise at 50%, 80% and 87% of VO2max. The similarity between the changes in concentration of active renin and noradrenaline would suggest that sympathetic nerve activity may have been responsible either for the release of active renin or for the conversion of inactive renin to its active form in the kidney.

Usefulness of Aerobic Exercise for Home Blood Pressure Control in Patients with Diabetes: Randomized Crossover Trial

“…As for the mechanism behind the anti-hypertensive effect, Kiyonaga et al reported that an increase in nitric oxide and prostaglandin E due to exercise acts directly on vascular smooth muscle to relax blood vessels and reduce peripheral vascular resistance to lower the BP [31]. It has also been shown that a decrease in sympathetic nerve activity due to a decrease in blood catecholamines at rest leads to relaxation of peripheral blood vessels and a decrease in cardiac output [32].…”

Estímulos para la liberación de aldosterona durante una actividad física intensa y de larga duración

“…Además, los receptores β de las células granulares aumentan de manera directa la secreción de renina ante la presencia estimuladora de los neurotransmisores simpáticos, en especial de la noradrenalina (16,17). Están bien documentados la hiperactividad simpática y el incremento de la concentración plasmática de la noradrenalina y la adrenalina durante la actividad física (18)(19)(20).…”