Activatory Receptor NKp30 Predicts NK Cell Activation During Controlled Human Malaria Infection

Walk, Jona; Sauerwein, Robert W.

doi:10.3389/fimmu.2019.02864

Cited by 12 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…59 Experimental, controlled human malaria infections (CHMI) have given valuable insights into the activation of NK cells during primary infection in malaria-na€ ıve individuals. Surprisingly, despite the known role for inflammatory cytokines (IL-12, IL-18) in activating less differentiated NK cells, the primary acute response during CHMI is characterised by activation (CD69 expression) of NKp30 + NK cells distributed across the differentiation spectrum but with CD56 dim cells dominating over CD56 bright cells 60 ; interestingly, these expansions were closely linked to the course of parasitaemia and resolved after treatment. 60 It is likely that both expansion and homing of activated CD56 bright NK cells toand their retention insecondary lymphoid tissues contribute to redistribution of NK cell subsets during active malaria infection.…”

Section: Impacts Of Chronic Persistent or Recurrent Infection On Nk mentioning

confidence: 99%

Regulation of the human NK cell compartment by pathogens and vaccines

Goodier

Riley

2021

Clin & Trans Imm

View full text Add to dashboard Cite

Natural killer cells constitute a phenotypically diverse population of innate lymphoid cells with a broad functional spectrum. Classically defined as cytotoxic lymphocytes with the capacity to eliminate cells lacking self-MHC or expressing markers of stress or neoplastic transformation, critical roles for NK cells in immunity to infection in the regulation of immune responses and as vaccineinduced effector cells have also emerged. A crucial feature of NK cell biology is their capacity to integrate signals from pathogen-, tumor-or stress-induced innate pathways and from antigenspecific immune responses. The extent to which innate and acquired immune mediators influence NK cell effector function is influenced by the maturation and differentiation state of the NK cell compartment; moreover, NK cell differentiation is driven in part by exposure to infection. Pathogens can thus mould the NK cell response to maximise their own success and/or minimise the damage they cause. Here, we review recent evidence that pathogen-and vaccine-derived signals influence the differentiation, adaptation and subsequent effector function of human NK cells.

show abstract

Section: Impacts Of Chronic Persistent or Recurrent Infection On Nk mentioning

confidence: 99%

Regulation of the human NK cell compartment by pathogens and vaccines

Goodier

Riley

2021

Clin & Trans Imm

View full text Add to dashboard Cite

show abstract

“…Our results support the prior observation that during MCMV infection high cell surface density of the Ly49H receptor on mouse NK cells facilitates the NK cell memory response ( Grassmann et al, 2019 ). Other studies have reported that NKp30, NKp46, or/and NKG2D mediate human NK cell–myeloid cell crosstalk and NK cell–tumor interactions to facilitate innate lymphoid cell expansion ( Matta et al, 2013 ; Trabanelli et al, 2017 ; Hart et al, 2019 ; Walk and Sauerwein, 2019 ). This suggests that the in vivo persistence observed in acute myeloid leukemia patients undergoing cytokine-induced memory-like NK cell therapy might be partly due to higher activating NK receptor levels, as was reported for NKp30, NKp44, NKp46, and NKG2D ( Romee et al, 2016 ; Foltz et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion

Shemesh

Pickering

Roybal

et al. 2022

Journal of Experimental Medicine

View full text Add to dashboard Cite

IL-12 is an essential cytokine involved in the generation of memory or memory-like NK cells. Mouse cytomegalovirus infection triggers NK receptor-induced, ligand-specific IL-12–dependent NK cell expansion, yet specific IL-12 stimulation ex vivo leading to NK cell proliferation and expansion is not established. Here, we show that IL-12 alone can sustain human primary NK cell survival without providing IL-2 or IL-15 but was insufficient to promote human NK cell proliferation. IL-12 signaling analysis revealed STAT5 phosphorylation and weak mTOR activation, which was enhanced by activating NK receptor upregulation and crosslinking leading to STAT5-dependent, rapamycin-sensitive, or TGFβ-sensitive NK cell IL-12–dependent expansion, independently of IL-12 receptor upregulation. Prolonged IL-2 culture did not impair IL-12–dependent ligand-specific NK cell expansion. These findings demonstrate that activating NK receptor stimulation promotes differential IL-12 signaling, leading to human NK cell expansion, and suggest adopting strategies to provide IL-12 signaling in vivo for ligand-specific IL-2–primed NK cell–based therapies.

show abstract

“…NKp30 is an activating receptor that plays a central role in the resistance to infectious disease [33]. Its high baseline expression favours a rapid reaction of NK cells to infections such as malaria [34]. The expression of NKp30 is likely hormone-dependent as its expression has been observed to change during the different phases of the menstrual cycle [35].…”

Section: Discussionmentioning

confidence: 99%

Gender as a factor affecting NK cell activity in patients successfully treated for chronic hepatitis C with direct-acting antivirals

Zientarska¹,

Mikuła-Pietrasik²,

Kaczmarek³

et al. 2021

cejoi

View full text Add to dashboard Cite

chronic hepatitis c (chc) affects the activity of natural killer (nk) cells, but successful interferonfree treatment partially restores it. the goal of this study was to assess whether gender influences nk functionality. we examined 21 post-menopausal women and 24 men with chc who were treated with direct-acting antivirals (Daa) and 33 healthy volunteers. using flow cytometry, we analysed kir2Ds4, nkG2D, nkp30, kir2Dl2/Dl3, nkG2a and trail on the surface of nk cells. intracellular granzyme B was also assessed and serum cXcl10 was quantified via elisa. overall, patients with chc had higher expression of kir2Ds4, nkG2a, and nkp30 relative to the control group. further, chc patients had a lower percentage of nk cells among lymphocytes relative to the control group. after treatment, kir2Ds4, kir2Dl2/Dl, nkG2a, trail and nkp30 on nk cells were decreased whilst the percentage of nk cells and the expression of granzyme B and nkG2D increased. Prior to treatment, serum cXcl10 was elevated, but it was inhibited post-treatment. we observed gender-specific differences in the expression of kir2Dl2/Dl3 (higher in women) and nkp30 (elevated in men) compared to chc/control groups. after treatment, kir2Dl2/Dl3, nkp30 and cXcl10 dropped only in the female group while granzyme B increased in the male group. in conclusion, the response of nk cells among men and women of post-menopausal ages with chc differs. our research may lead to more studies on the different nature of female and male immune systems in the context of hcV infection and treatment.

show abstract

Activatory Receptor NKp30 Predicts NK Cell Activation During Controlled Human Malaria Infection

Cited by 12 publications

References 37 publications

Regulation of the human NK cell compartment by pathogens and vaccines

Regulation of the human NK cell compartment by pathogens and vaccines

Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion

Gender as a factor affecting NK cell activity in patients successfully treated for chronic hepatitis C with direct-acting antivirals

Contact Info

Product

Resources

About