Activation rates and chemical recovery of67Cu produced with low energy proton irradiation of enriched70Zn targets

Molecular imaging with copper-64

“…The worldwide availability of 67 Cu has suffered from irregular supply, limited production yields and radioisotope contaminants ( 62 Zn, 67 Ga, 65 Zn, 55 Co, 58 Co, 64 Cu and 57 Ni). The presence of high yields of 64 Cu ( 68 Zn via p,2p reaction) being the greatest challenge as its elimination requires its decay before the 67 Cu can be utilised.…”

“…Cu-67 can be produced, by bombardment, of 67 Zn with neutrons in high flux reactors [47,[52][53][54][55] or using alpha particles on Ni or high energy protons (P60 MeV) on Zn (natural or enriched 68 Zn) [48,49,[56][57][58][59][60]. The worldwide availability of 67 Cu has suffered from irregular supply, limited production yields and radioisotope contaminants ( 62 Zn, 67 Ga, 65 Zn, 55 Co, 58 Co, 64 Cu and 57 Ni).…”

Development of novel radionuclides for medical applications

“…Evidently the 68 Zn(p,2p) 67 Cu reaction is more suitable. The low‐energy reaction 70 Zn(p,α) 67 Cu was investigated for practical production, but the batch yield was small . Presently, work is underway in a few laboratories to develop the 68 Zn(p,2p) 67 Cu production route using about 80 MeV protons .…”

“…The low-energy reaction 70 Zn(p,α) 67 Cu was investigated for practical production, but the batch yield was small. 26,113 Presently, work is underway in a few laboratories to develop the 68 Zn(p,2p) 67 Cu production route using about 80 MeV protons. 114 The use of an enriched 68 Zn target is necessary to ensure the desired specific radioactivity, because a nat Zn target leads to considerable formation of stable 65 Cu.…”

Somatostatin analogues labeled with copper radioisotopes: current status

“…67 Cu has the longest half-life of the copper isotopes, making it potentially useful for both diagnosis and treatment, but is difficult to produce [32, 35]. …”