Activation of σ-1 receptor mitigates estrogen withdrawal-induced anxiety/depressive-like behavior in mice via restoration of GABA/glutamate signaling and neuroplasticity in the hippocampus

Ren, Peng; Wang, Jing-Ya; Chen, Hong-Lei; Wang, Yue; Cui, Lin-Yu; Duan, Jing-Yao; Guo, Wen-Zhi; Zhao, Yong-Qi; Li, Yun-Feng

doi:10.1016/j.jphs.2024.02.003

Cited by 5 publications

(1 citation statement)

References 42 publications

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“…It plays a vital role as an inhibitory neurotransmitter in the central nervous system. Imbalances in GABA levels have been linked to various neurological diseases, including Alzheimer's and Parkinson's disease, as well as psychological disorders such as anxiety, depression, and stress [16]. Until recently, it was widely believed that GABA could not cross the blood-brain barrier, leading to neglect of its potential effects on the brain [17].…”

Section: Introductionmentioning

confidence: 99%

Exploring Phenotype, Genotype, and the Production of Promising GABA Postbiotics by Lactiplantibacillus plantarum: A Comprehensive Investigation

Abdel-motaal,

Abdelazez,

Wang

et al. 2024

Fermentation

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This study aims to investigate the probiotic properties of various isolated strains of Lactiplantibacillus plantarum. Specifically, the focus is on examining the expression of the glutamic acid decarboxylase (GAD) gene and its role in the production of gamma-aminobutyric acid (GABA), a promising postbiotic metabolite. The investigation includes comprehensive analyses of morphology, genetics, resilience against bile, NaCl, and simulated pancreatin juice (SPJ), carbohydrate fermentation patterns, antibacterial activity, susceptibility to antibiotics, and the presence of β-D-galactosidase and GAD enzymes. Six L. plantarum strains exhibited remarkable resilience against bile, NaCl, and SPJ, as well as susceptibility to antibiotics and antagonistic behavior against pathogens. These strains also showed the presence of β-D-galactosidase. Additionally, five L. plantarum strains were found to harbor the gad gene. Further biochemical analysis of four specific L. plantarum strains revealed promising profiles consisting of antibiotics, vitamins, hormones, and a diverse array of metabolites with potential immunotherapeutic properties. This study highlights the substantial potential of Lactiplantibacillus plantarum in generating beneficial postbiotic metabolites. The identified strains offer exciting avenues for further exploration, with potential applications in functional foods and pharmaceuticals. This research opens up possibilities for harnessing the probiotic and postbiotic potential of L. plantarum to develop novel products with health-promoting properties.

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Section: Introductionmentioning

confidence: 99%

Exploring Phenotype, Genotype, and the Production of Promising GABA Postbiotics by Lactiplantibacillus plantarum: A Comprehensive Investigation

Abdel-motaal,

Abdelazez,

Wang

et al. 2024

Fermentation

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Astrocyte-specific activation of sigma-1 receptors in mPFC mediates the faster onset antidepressant effect by inhibiting NF-κB-induced neuroinflammation

Wang,

Ren,

Cui

et al. 2024

Brain, Behavior, and Immunity

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Spatial Transcriptomics-Aided Localization for Single-Cell Transcriptomics with STALocator

Li,

Shen,

Zhang

2024

Preprint

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Single-cell RNA-sequencing (scRNA-seq) techniques can measure gene expression at the single-cell resolution but lack spatial information. The spatial transcriptomics (ST) techniques simultaneously provide gene expression data and spatial information. However, the data quality on the spatial resolution or gene coverage is still much lower than the single-cell transcriptomics data. To this end, we develop a Spatial Transcriptomics-Aided Locator for single-cell transcriptomics (STALocator) to localize single cells to corresponding ST data. Applications on simulated data showed that STALocator performed better than other localization methods from different angles. When applied to human brain scRNA-seq data and dorsolateral prefrontal cortex 10x Visium data, STALocator could robustly reconstruct the laminar organization of layer-associated cell types. Applications on scRNA-seq data and Spatial Transcriptomics data of human squamous cell carcinoma illustrated that STALocator could robustly reconstruct the relative spatial relationship between tumor-specific keratinocytes, microenvironment-associated cell populations, and immune cells. Moreover, STALocator could enhance gene expression patterns for Slide-seqV2 data and predict genome-wide gene expression data for FISH data, leading to the identification of more spatially variable genes and more biologically relevant GO terms compared to raw data.

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Activation of σ-1 receptor mitigates estrogen withdrawal-induced anxiety/depressive-like behavior in mice via restoration of GABA/glutamate signaling and neuroplasticity in the hippocampus

Cited by 5 publications

References 42 publications

Exploring Phenotype, Genotype, and the Production of Promising GABA Postbiotics by Lactiplantibacillus plantarum: A Comprehensive Investigation

Exploring Phenotype, Genotype, and the Production of Promising GABA Postbiotics by Lactiplantibacillus plantarum: A Comprehensive Investigation

Astrocyte-specific activation of sigma-1 receptors in mPFC mediates the faster onset antidepressant effect by inhibiting NF-κB-induced neuroinflammation

Spatial Transcriptomics-Aided Localization for Single-Cell Transcriptomics with STALocator

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