Activation of β-catenin in mesenchymal progenitors leads to muscle mass loss

Kajabadi, Nasim; Low, Marcela; Jacques, Eric; Lad, Heta; Tung, Lin; Babaeijandaghi, Farshad; Gamu, Daniel; Zelada, Diego; Wong, Ching; Chang, Chiung‐Wen; Yi, Lin; Wosczyna, Michael N.; Rando, Thomas A.; Henríquez, Juan Pablo; Gibson, William T.; Gilbert, Penney M.; Rossi, Fábio

doi:10.1016/j.devcel.2023.02.009

Cited by 5 publications

(1 citation statement)

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“…Upon activation, FAPs generate numerous cytokines, implying their potential involvement in modulating the inflammatory response. Beyond regeneration, a growing body of evidence underscores the pivotal role of FAPs in regulation of muscle homeostasis in both health and disease 23 – 26 . Here, we identify a subpopulation of FAPs that express dipeptidyl peptidase IV (DPPIV) as a key component of the niche for SRRMs in adult skeletal muscle.…”

Section: Introductionmentioning

confidence: 99%

DPPIV+ fibro-adipogenic progenitors form the niche of adult skeletal muscle self-renewing resident macrophages

Babaeijandaghi,

Kajabadi,

Long

et al. 2023

Nat Commun

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Adult tissue-resident macrophages (RMs) are either maintained by blood monocytes or through self-renewal. While the presence of a nurturing niche is likely crucial to support the survival and function of self-renewing RMs, evidence regarding its nature is limited. Here, we identify fibro-adipogenic progenitors (FAPs) as the main source of colony-stimulating factor 1 (CSF1) in resting skeletal muscle. Using parabiosis in combination with FAP-deficient transgenic mice (PdgfrαCreERT2× DTA) or mice lacking FAP-derived CSF1 (PdgfrαCreERT2× Csf1flox/null), we show that local CSF1 from FAPs is required for the survival of both TIM4- monocyte-derived and TIM4+ self-renewing RMs in adult skeletal muscle. The spatial distribution and number of TIM4+ RMs coincide with those of dipeptidyl peptidase IV (DPPIV)+ FAPs, suggesting their role as CSF1-producing niche cells for self-renewing RMs. This finding identifies opportunities to precisely manipulate the function of self-renewing RMs in situ to further unravel their role in health and disease.

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Section: Introductionmentioning

confidence: 99%