Activation of the receptor KIT induces the secretion of exosome‐like small extracellular vesicles
Annika Pfeiffer,
Geethani Bandara,
Jennifer D. Petersen
et al.
Abstract:The receptor tyrosine kinase (RTK) KIT and its ligand stem cell factor (SCF) are essential for human mast cell (huMC) survival and proliferation. HuMCs expressing oncogenic KIT variants secrete large numbers of extracellular vesicles (EVs). The role KIT plays in regulating EV secretion has not been examined. Here, we investigated the effects of stimulation or inhibition of KIT activity on the secretion of small EVs (sEVs). In huMCs expressing constitutively active KIT, the quantity and quality of secreted sEVs… Show more
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