Activation of the NRF2-ARE signalling pathway by the Lentinula edodes polysaccharose LNT alleviates ROS-mediated cisplatin nephrotoxicity

Chen, Qian; Peng, Huixia; Liu, Dong; Chen, Lijuan; Ma, Xiaolong; Peng, Yuping; Dai, Shejiao; Liu, Qiang

doi:10.1016/j.intimp.2016.04.007

Cited by 57 publications

(27 citation statements)

References 25 publications

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“…In addition, the results of an in vivo study conducted on Antrodia cinnamomea showed the positive effect of this mushroom species on the expression of Nrf2 [45]. However, the present study on L. edodes species showed that mainly lentinan present in this species exerted an anti-inflammatory effect, causing, inter alia, an increase in Nrf2 expression [46].…”

Section: Resultscontrasting

confidence: 58%

Lentinula edodes as a Source of Bioelements Released into Artificial Digestive Juices and Potential Anti-inflammatory Material

Muszyńska

Kała

Włodarczyk

et al. 2019

Biol Trace Elem Res

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Lentinula edodes (shiitake), an edible and medicinal mushroom, was chosen for this study with the aim of evaluating the possibility of release of bioelements into artificial digestive juices and analyzing the anti-inflammatory properties. The extracts were prepared from fruiting bodies and biomass enriched with copper (Cu), zinc (Zn), and selenium (Se). The content of bioelements was analyzed by total reflection X-ray fluorescence method. Relatively low content of elements was observed in the fruiting bodies: Cu-1.6, Zn-7.6, and Se-0.12 mg/100 g d.w. compared to mycelial cultures. The anti-inflammatory properties were evaluated in RAW 264.7 cells. Based on the levels of cyclooxygenase 2 protein, nuclear factor erythroid 2-related factor 2, and peroxisome proliferator-activated receptor γ determined using Western blot technique, it was found that the addition of bioelements enhanced the anti-inflammatory properties of mycelium. This indicates that L. edodes cultured on a suitable medium may be used as a potential component of anti-inflammatory products. Keywords Shiitake. Biologically active elements. Extraction in digestive juices. Medicinal properties of mushrooms. RAW 264.7 cells * Bożena Muszyńska

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Section: Resultscontrasting

confidence: 58%

Lentinula edodes as a Source of Bioelements Released into Artificial Digestive Juices and Potential Anti-inflammatory Material

Muszyńska

Kała

Włodarczyk

et al. 2019

Biol Trace Elem Res

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“…Previous studies have confirmed that DDP-induced kidney injury is primarily caused by apoptosis ( 7 ) due to oxidative stress injury and the inflammatory infiltration of epithelial cells in the renal proximal tubule ( 8 ). In a previous study conducted by the present research team, it was shown that DDP induces apoptosis by causing oxidative stress in HK-2 proximal tubule epithelial cells ( 9 ). Mitogen-activated protein kinase (MAPK) signaling pathways have been demonstrated to serve a key role in this pathological process.…”

Section: Introductionmentioning

confidence: 77%

Schizandrin B inhibits the cis‑DDP‑induced apoptosis of HK‑2 cells by activating ERK/NF‑κB signaling to regulate the expression of survivin

Liu

Song

et al. 2018

Int J Mol Med

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The nephrotoxicity of cisplatin limits its clinical application. Schizandrin B (SchB) has been demonstrated to have a variety of potential cytoprotective activities. The present study explored the molecular mechanisms by which SchB inhibits the dichlorodiammine platinum (DDP)-induced apoptosis of HK-2 proximal tubule epithelial cells. In vitro assays demonstrated that SchB increased the viability of HK-2 cells, alleviated the cis-DDP-induced activation of caspase-3, reduced apoptosis and improved the nuclear morphology of HK-2 cells. Additionally, the mechanism underlying the cis-DDP-induced apoptosis was indicated to involve the activation of p53, c-Jun-N-terminal kinase (JNK) and p38 signaling. Furthermore, SchB was demonstrated to activate extracellular signal-regulated kinase (ERK) and nuclear factor κB (NF-κB) signaling, and induce the expression of survivin. The inhibition of ERK and NF-κB signaling using U0126 and pyrollidine dithiocarbamate, respectively, inhibited the expression of survivin, whereas blocking the expression of survivin using small interfering RNA inhibited the alleviating effect of SchB on cis-DDP-induced apoptosis as indicated by a reduction in cleaved caspase-3 expression. In conclusion, SchB regulates ERK/NF-κB signaling to induce the expression of survivin, thereby alleviating cis-DDP-induced renal injury.

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“…The oxidative condition could stimulate kidney cells to produce a cytoprotective response which acts through the antioxidant response element (ARE) and nuclear factor erythroid 2-related factor 2 (Nrf2). In the nucleus, Nrf2 activates the expression of ARE-driven genes, such as heme oxygenase 1 (HO-1), NAD(P)H:quinone oxidoreductase 1 (NQO1), which alleviate oxidative stress-induced cellular damage [ 6 ]. Furthermore, cisplatin could induce apoptosis and necrosis in the proximal tubule [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

S‐Allylmercaptocysteine Attenuates Cisplatin‐Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation

Zhu

Jiang

et al. 2017

Nutrients

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Cisplatin is a potent chemotherapeutic agent, but its clinical usage is limited by nephrotoxicity. S-allylmercaptocysteine (SAMC), one of the water-soluble organosulfur garlic derivatives, has antioxidant and anti-inflammatory properties and plays an important role in protecting cells from apoptosis. This study aims to examine the protective effects of SAMC on cisplatin nephrotoxicity and to explore the mechanism of its renoprotection. Rats were treated with cisplatin with or without pre-treatment with SAMC. Renal function, histological change, oxidative stress markers and antioxidant enzyme activities were investigated. Apoptotic marker, nuclearfactor (NF)-κB activity, expression of nuclear factor erythroid 2-related factor 2 (Nrf2), NAD(P)H:quinone oxidoreductase 1 (NQO1) and inflammatory cytokines were also examined. The effect of SAMC on cell viability and apoptosis was examined in cultured human kidney (HK-2) cells. SAMC was confirmed to significantly attenuate cisplatin-induced renal damage by using histological pathology and molecular biological method. Pre-treatment with SAMC reduced NF-κB activity, up-regulated Nrf2 and NQO1 expression and down-regulated inflammatory cytokine levels after cisplatin administration. Cisplatin-induced apoptosis in HK-2 cells was significantly attenuated by SAMC. Thus our results suggest that SAMC could be a potential therapeutic agent in the treatment of the cisplatin-induced nephrotoxicity through its anti-apoptotic, anti-oxidant and anti-inflammatory effects.

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Activation of the NRF2-ARE signalling pathway by the Lentinula edodes polysaccharose LNT alleviates ROS-mediated cisplatin nephrotoxicity

Cited by 57 publications

References 25 publications

Lentinula edodes as a Source of Bioelements Released into Artificial Digestive Juices and Potential Anti-inflammatory Material

Lentinula edodes as a Source of Bioelements Released into Artificial Digestive Juices and Potential Anti-inflammatory Material

Schizandrin B inhibits the cis‑DDP‑induced apoptosis of HK‑2 cells by activating ERK/NF‑κB signaling to regulate the expression of survivin

S‐Allylmercaptocysteine Attenuates Cisplatin‐Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation

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