Activation of the Local Regenerative System of the Heart

Germani, Antonia; Capogrossi, Maurizio C.

doi:10.1002/9780470988909.ch11

Cited by 1 publication

(2 citation statements)

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“…For example, HMGB1 enhances axonal regeneration [64,65] and myogenesis [122,123] in a RAGE-dependent manner. Furthermore, HMGB1 is implicated in stem cell homing and development [124][125][126]. Low doses of HMGB1 are capable of activating stem cells which is expected to be useful in tissue regeneration, as demonstrated for cardiac repair [126].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, HMGB1 is implicated in stem cell homing and development [124][125][126]. Low doses of HMGB1 are capable of activating stem cells which is expected to be useful in tissue regeneration, as demonstrated for cardiac repair [126]. In embryonic stem cells, HMGB1 is capable of inducing neuronal characteristics in a RAGE-dependent manner [39].…”

Section: Discussionmentioning

confidence: 99%

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RAGE as a Receptor of HMGB1 (Amphoterin): Roles in Health and Disease

Rauvala

Rouhiainen

2007

CMM

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HMGB1/Amphoterin is a ubiquitous, highly conserved DNA-binding protein that can be also released to the extracellular space by various cell types. Extracellular HMGB1 regulates migratory responses of several cell types through binding to RAGE that communicates with the cytoskeleton to regulate cell motility. HMGB1-induced cell signalling has been associated with mechanisms of several diseases, including cancer, sepsis, rheumatoid arthritis, stroke and atherosclerosis. This article reviews the evidence linking the functional roles of HMGB1 to RAGE signalling. Furthermore, we discuss the molecular and cellular mechanisms that may explain the roles of HMGB1/RAGE in diverse disease processes.

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