Activation of the hypothalamus characterizes the response to acupuncture stimulation in heroin addicts

Liu, Sheng; Zhou, Wenhua; Ruan, Xingzhong; Li, Ronghui; Lee, Tatia; Weng, Xuchu; Hu, Jun; Yang, Guodong

doi:10.1016/j.neulet.2007.04.078

Cited by 46 publications

(39 citation statements)

References 18 publications

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“…Fu et al [76] found patients with Alzheimer's disease had more activation in the cingulate gyrus and cerebellum. Liu et al [77] found more robust activation in the hypothalamus in heroin addicts. Wu et al [78] found deactivation in primary motor cortex (M1), parahippocampal gyrus, and higher cognitive areas and more activation in the cuneus and the insula in children with spastic cerebral palsy but not in healthy children.…”

Section: Descriptive Findings Of Differences Between Patients and Heamentioning

confidence: 96%

Characterizing acupuncture stimuli using brain imaging with fMRI – a systematic review and meta-analysis of the literature

Huang

Pach

Napadow

et al. 2012

Deutsche Zeitschrift für Akupunktur

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Background: The mechanisms of action underlying acupuncture, including acupuncture point specificity, are not well understood. In the previous decade, an increasing number of studies have applied fMRI to investigate brain response to acupuncture stimulation. Our aim was to provide a systematic overview of acupuncture fMRI research considering the following aspects: 1) differences between verum and sham acupuncture, 2) differences due to various methods of acupuncture manipulation, 3) differences between patients and healthy volunteers, 4) differences between different acupuncture points.

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Section: Descriptive Findings Of Differences Between Patients and Heamentioning

confidence: 96%

Characterizing acupuncture stimuli using brain imaging with fMRI – a systematic review and meta-analysis of the literature

Huang

Pach

Napadow

et al. 2012

Deutsche Zeitschrift für Akupunktur

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“…Numerous clinical studies have revealed that acupuncture treatment is capable of reversing and even normalizing abnormal neuroimaging activity in patients with chronic pain [138–140], cerebral palsy [141], chronic stroke [142–145], Parkinson's disease [146], Alzheimer's disease [147], major depressive disorder [148, 149], and heroin addiction [150]. Moreover, most reversal and normalization of neuroimaging signals are correlated with clinical improvement.…”

Section: Nau-associated Central Effects Of Acupuncturementioning

confidence: 99%

Neural Acupuncture Unit: A New Concept for Interpreting Effects and Mechanisms of Acupuncture

Zhang

Wang

McAlonan

2012

Evidence-Based Complementary and Alternative Medicine

200

171

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When an acupuncture needle is inserted into a designated point on the body and mechanical or electrical stimulation is delivered, various neural and neuroactive components are activated. The collection of the activated neural and neuroactive components distributed in the skin, muscle, and connective tissues surrounding the inserted needle is defined as a neural acupuncture unit (NAU). The traditionally defined acupoints represent an anatomical landmark system that indicates local sites where NAUs may contain relatively dense and concentrated neural and neuroactive components, upon which acupuncture stimulation would elicit a more efficient therapeutic response. The NAU-based local mechanisms of biochemical and biophysical reactions play an important role in acupuncture-induced analgesia. Different properties of NAUs are associated with different components of needling sensation. There exist several central pathways to convey NAU-induced acupuncture signals, Electroacupuncture (EA) frequency-specific neurochemical effects are related to different peripheral and central pathways transmitting afferent signals from different frequency of NAU stimulation. More widespread and intense neuroimaging responses of brain regions to acupuncture may be a consequence of more efficient NAU stimulation modes. The introduction of the conception of NAU provides a new theoretical approach to interpreting effects and mechanisms of acupuncture in modern biomedical knowledge framework.

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“…Different activation patterns between patients and healthy controls have been reported [137], in line with evidence from animal studies that acupuncture differs in its actions in normal versus inflammatory states [138]. A recent study on heroin addicts suggests that the hypothalamus may be involved in De Qi [139].…”

Section: Mechanism Of Actionmentioning

confidence: 64%

Transcutaneous Electrical Nerve Stimulation and Acupuncture

Johnson

2010

Evidence‐Based Chronic Pain Management

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Activation of the hypothalamus characterizes the response to acupuncture stimulation in heroin addicts

Cited by 46 publications

References 18 publications

Characterizing acupuncture stimuli using brain imaging with fMRI – a systematic review and meta-analysis of the literature

Characterizing acupuncture stimuli using brain imaging with fMRI – a systematic review and meta-analysis of the literature

Neural Acupuncture Unit: A New Concept for Interpreting Effects and Mechanisms of Acupuncture

Transcutaneous Electrical Nerve Stimulation and Acupuncture

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