Activation of the hypothalamus characterizes the acupuncture stimulation at the analgesic point in human: a positron emission tomography study

Hsieh, Jen Chuen; Tu, Cheng-Hao; Chen, Fang Pey; Chen, Min Chi; Yeh, Ta‐Chuan; Cheng, Hui; Wu, Yu Te; Liu, Ru‐Shi; Ho, Low Tone

doi:10.1016/s0304-3940(01)01952-8

Cited by 195 publications

(120 citation statements)

References 17 publications

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“…All these activated differences suggest that the results obtained from all subjects were less sensitive than those in the homogeneous group. Activation of the insula has been reported in previous acupuncture studies (32)(33)(34). It was consistent with electrophysiological studies and clinical investigations (35) showing the insula's involvement in emotional processing (fear, uneasiness, and so forth) and ascending visceral symptoms (36).…”

Section: Discussionsupporting

confidence: 89%

Evaluation of group homogeneity during acupuncture stimulation in fMRI studies

Sun

Qin

Dong

et al. 2010

Magnetic Resonance Imaging

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Purpose: To evaluate the extent of individual differences of functional MRI (fMRI) signal changes induced by acupuncture stimulation. Materials and Methods:Acupuncture at ST36 and checkerboard stimulation was applied to 16 subjects. We calculated the mean distance using beta values in a generalized linear model (GLM) analysis and employed it to study the group homogeneity by detecting the outliers.Results: A more significant individual difference was presented in acupuncture stimulation compared with visual stimulation through evaluation of the mean distance. From the group results, we found that the activations were more significant in the homogeneous group results. Combining the behavior and fMRI results, there was no direct correlation between deqi index and mean distance in acupuncture stimulation. The deqi index of the outlier was in the normal range and did not differ significantly from others. Conclusion:Traditional group results without removing outliers were not sensitive enough to detect the real acupuncture effect. We suggest that individual difference should be taken into consideration for future acupuncture studies. Also, group analysis paralleled with individual analysis is critical for a full understanding of acupuncture effects.

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Section: Discussionsupporting

confidence: 89%

Evaluation of group homogeneity during acupuncture stimulation in fMRI studies

Sun

Qin

Dong

et al. 2010

Magnetic Resonance Imaging

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“…Earlier studies demonstrated that stimulation of acupoint LI4 induced analgesia in humans (20,21,(30)(31)(32), and antinociception in animals (33,34). However, the current results showed no similar orofacial effect of acupoint LI4 in these animals.…”

Section: Discussioncontrasting

confidence: 90%

Opioidergic orofacial antinociception induced by electroacupuncture at acupoint St36

Almeida

Perez

Francischi

et al. 2008

Braz J Med Biol Res

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The participation of opioids in the antinociceptive effect of electroacupuncture was evaluated in terms of nociception produced by thermal stimuli applied to the face of male Wistar rats, weighing 180-230 g. Electrical stimulation (bipolar and asymmetric square wave with 0.5 mA intensity for 20 min) of acupoint St36, located in the anterior tibial muscle 10 mm distal to the knee joint, induced antinociception in the present model, which was maintained for 150 min. Acupoint LI4, located in the junction of the first and second metacarpal bones, did not achieve antinociception at any frequency studied (5 Hz: 1.7 ± 0.1; 30 Hz: 1.8 ± 0.1; 100 Hz: 1.7 ± 0.1 vs 1.4 ± 0.2). The antinociception obtained by stimulation of acupoint St36 was only achieved when high frequency 100 Hz (3.0 ± 0.2 vs 1.0 ± 0.1) was used, and not with 5 or 30 Hz (1.2 ± 0.2 and 0.7 ± 0.1 vs 1.0 ± 0.1). The antinociceptive effect of acupuncture occurred by opioid pathway activation, since naloxone (1 and 2 mg/kg, subcutaneously) antagonized it (1.8 ± 0.2 and 1.7 ± 0.2 vs 3.0 ± 0.1).

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“…Han et al [10] have reported that the antibiotic activity of 1 mg of allicin, which is a sulfoxide (+)-S-methyl-1-cysteine, was assimilated to that of 15 IU of penicillin. Recent studies have also demonstrated an inhibitory effect by aqueous extracts on many bacterial and fungal species [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Eco-friendly synthesis of metal nanoparticles using ginger and garlic extracts as biocompatible novel antioxidant and antimicrobial agents

et al. 2018

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Ginger and garlic plants were used for the preparation of water and ethanolic extracts. The silver, copper, iron and zinc nanoparticles were eco-friendly synthesized using ginger and garlic extracts and their antioxidant and antibacterial activities were evaluated. The growth of nanoparticles was complemented with characterization using TEM and UV-Vis spectroscopic analysis. Transmission electron microscopy revealed the presence of mono-dispersed metals nanoparticles and silver nanoparticles of ginger have the smallest particle size around 10.10-18.33 nm. The investigated samples were evaluated as antibacterial agents against Staphylococcus aureus, Klebsiella pneumoniae, Candida albicans, Bacillus subtilis, Erwinia carotovora and Proteus vulgaris and as antifungal agents against C. albicans. The results of antimicrobial tests indicate that these nanoparticles possess significant activities compared to the results obtained by antibiotic standard. In addition, the total polyphenols, fractionation of phenols, flavonoids by high-performance liquid chromatography systems and antioxidant activity were evaluated. Graphical AbstractComparison of the DPPH and ABTS antioxidant results.

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Activation of the hypothalamus characterizes the acupuncture stimulation at the analgesic point in human: a positron emission tomography study

Cited by 195 publications

References 17 publications

Evaluation of group homogeneity during acupuncture stimulation in fMRI studies

Evaluation of group homogeneity during acupuncture stimulation in fMRI studies

Opioidergic orofacial antinociception induced by electroacupuncture at acupoint St36

Eco-friendly synthesis of metal nanoparticles using ginger and garlic extracts as biocompatible novel antioxidant and antimicrobial agents

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