Activation of the complement system by nanoparticles and strategies for complement inhibition

Haroon, Hajira B.; Dhillon, Elisha; Farhangrazi, Z. Shadi; Trohopoulos, Panagiotis N.; Simberg, Dmitri; Moghimi, S. Moein

doi:10.1016/j.ejpb.2023.11.006

European Journal of Pharmaceutics and Biopharmaceutics

2023

DOI: 10.1016/j.ejpb.2023.11.006

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Activation of the complement system by nanoparticles and strategies for complement inhibition

Hajira B. Haroon,

Elisha Dhillon,

Z. Shadi Farhangrazi

et al.

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2024

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Anti-Poly(ethylene glycol) (PEG) Antibodies: From Where Are We Coming and Where Are We Going

Simberg,

Moghimi

2024

JNT

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PEGylation technology confers stability and modulates the biological performance of a broad range of preclinical and clinical nanopharmaceuticals. However, the emerging PEG immunogenicity in the general population is thought to impact the efficacy and safety of PEGylated medicines. Despite this, the clinical significance of PEG immunogenicity is still not clear and remains debatable. By considering the strategic importance of the PEGylation technology in nanopharmaceutical engineering, we raise a number of critical questions and briefly discuss gaps in the knowledge of PEG immunogenicity and its clinical significance.

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Anti-Poly(ethylene glycol) (PEG) Antibodies: From Where Are We Coming and Where Are We Going

Simberg,

Moghimi

2024

JNT

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Activation of the complement system by nanoparticles and strategies for complement inhibition

Cited by 1 publication

References 90 publications

Anti-Poly(ethylene glycol) (PEG) Antibodies: From Where Are We Coming and Where Are We Going

Anti-Poly(ethylene glycol) (PEG) Antibodies: From Where Are We Coming and Where Are We Going

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