1996
DOI: 10.1016/0162-3109(96)00085-9
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Activation of the complement, coagulation, fibrinolytic and kallikrein-kinin systems during attacks of hereditary angioedema

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Cited by 35 publications
(30 citation statements)
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“…This effect is responsible for the development of edema and the movement of fluid from the intravascular space to the perivascular tissues. A significant activation of the terminal pathway of the C sequence was observed during the attack phase of hereditary AE as documented by the increased levels of SC5b-9 measured in patients during the attack phase [71]. These data together with the in vitro and in vivo observations indicating a clear permeabilizing activity of SC5b-9 [27] suggest the existence of a cross-talk between the C and the kinin systems in induction of vascular leakage during the acute episodes of AE.…”
Section: Angioedema As a Model Of Crosstalk Between Complement Andmentioning
confidence: 99%
“…This effect is responsible for the development of edema and the movement of fluid from the intravascular space to the perivascular tissues. A significant activation of the terminal pathway of the C sequence was observed during the attack phase of hereditary AE as documented by the increased levels of SC5b-9 measured in patients during the attack phase [71]. These data together with the in vitro and in vivo observations indicating a clear permeabilizing activity of SC5b-9 [27] suggest the existence of a cross-talk between the C and the kinin systems in induction of vascular leakage during the acute episodes of AE.…”
Section: Angioedema As a Model Of Crosstalk Between Complement Andmentioning
confidence: 99%
“…Bradykinin stimulates endothelial cell prostaglandin synthesis, leading to inactivation of platelet function [24,25], and increased superoxide [26] and nitric oxide formation [27]. Consequently bradykinin is linked with the pathophysiological processes that accompany inflammation and tissue damage which is thought to play a major role in the symptomatology of acute attacks in patients with angiodema [12,28].…”
mentioning
confidence: 99%
“…Foram realizadas dosagens do nível sérico de C1-INH, C4 e C3 por nefelometria, com a utilização de anti-soro especí-fico para os componentes do complemento (Behring, Marburg, GE) 12,19 e ensaio hemolítico para avaliação das vias clássica e alternativa do sistema complemento (CH50 e APH50). Em resumo, o CH50 e o APH50 foram avaliados com a determinação da habilidade do soro em lisar eritrócitos de carneiro sensibilizados com anticorpo e eritrócitos de coelho, respectivamente.…”
Section: Exames Realizadosunclassified
“…Após diluição do soro, observa-se o valor correspondente a 50% de hemólise dos eritrócitos. A leitura da reação é feita em espectrofotômetro (CELM-E210D) a 541 nm para o CH50 e a 412 nm para o APH50 19,20 . Os valores de ambas as reações são obtidos após a construção …”
Section: Exames Realizadosunclassified