Activation of the cardiac endothelin system in left ventricular hypertrophy before onset of heart failure in TG(mREN2)27 rats

Abstract

Cardiac ET and angiotensin systems are co-activated in compensated cardiac hypertrophy before onset of heart failure, and thus may be involved in the mechanism by which cardiac remodelling and progression of left ventricular dysfunction occur in TG(mREN2)27 rats.

The Effects of a Novel Endothelin Receptor Antagonist, Macitentan, on Right Ventricular Substrate Utilization and Function in a Sugen5416/Hypoxia Rat Model of Severe Pulmonary Artery Hypertension

“…In the adult myocardium, ET-1 plays a role in proper coronary blood flow by regulating vascular tone (Drawnell et al, 2012). Elevated levels of ET-1 have been inversely correlated with cardiac function and have been suggested as a marker for future heart failure (Selvais et al, 2000;Zolk et al, 2002). Treatment with endothelin receptor antagonist in our study was associated with a decrease in RV glucose uptake, improved hemodynamics and RV function.…”

Elevated InsP3R expression underlies enhanced calcium fluxes and spontaneous extra-systolic calcium release events in hypertrophic cardiac myocytes

“…2). 38,39 Moreover, phospholipase C beta1 levels have also been recently reported to be increased during atrial hypertrophy. 40 17 This role of Ca 2+ release through InsP 3 Rs has been substantiated in InsP 3 R2-deficient mice, in which ET-1-and InsP 3 -stimulated arrhythmias in atrial myocytes were completely abolished.…”

Effects of chronic endothelin-1 stimulation on cardiac myocyte contractile function

“…Specifically, augmented cardiac endothelin-1 (ET-1) concentrations and increased circulating levels of ET-1 have been identified as occurring with the development of left ventricular dysfunction (32,33) and are related to the severity of heart failure (21). Activation of cardiac ET receptors in turn modulates a wide variety of biological processes including vascular tone, growth, and myocardial contractile function.…”