2002
DOI: 10.1128/jvi.76.19.9877-9887.2002
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Activation of Terminally Differentiated Human Monocytes/Macrophages by Dengue Virus: Productive Infection, Hierarchical Production of Innate Cytokines and Chemokines, and the Synergistic Effect of Lipopolysaccharide

Abstract: Dengue virus (DV) primarily infects blood monocytes (MO) and tissue macrophages (M).

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Cited by 144 publications
(124 citation statements)
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References 70 publications
(79 reference statements)
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“…It is well-established that infecting cell lines with dengue virus in vitro induces expression of various chemokines, including CXCL1/IL-8 (47-50), CCL3/MIP-1␣ (47, 51, 52), CCL5/RAN-TES (47,50,53), and CCL4/MIP-1␤ (51, 52). In contrast, ours is the first study to show in vivo induction of chemokines following infection with dengue virus.…”
Section: Discussionmentioning
confidence: 99%
“…It is well-established that infecting cell lines with dengue virus in vitro induces expression of various chemokines, including CXCL1/IL-8 (47-50), CCL3/MIP-1␣ (47, 51, 52), CCL5/RAN-TES (47,50,53), and CCL4/MIP-1␤ (51, 52). In contrast, ours is the first study to show in vivo induction of chemokines following infection with dengue virus.…”
Section: Discussionmentioning
confidence: 99%
“…Macrophages (M ) are the major source of inflammatory cytokines, 12 as well as the major target cells for DV replication. 13,14 However, M are heterogeneous throughout the body, 15 and the phenotypic and functional diversities of M are influenced by cytokines, which regulate their differentiation, tissue distribution, and defense to invaded pathogens.…”
Section: Introductionmentioning
confidence: 99%
“…Consistent with that idea, many viral infections induce expression of chemokines, which are most likely involved in orchestrating recruitment of effector leukocytes to the sites of infection (24 -26). DV is known to induce expression of a number of chemokines, including CXCL1/IL-8 (27)(28)(29)(30), CCL3/MIP-1␣ (27,31,32), CCL5/RANTES (27,30,33), and CCL4/MIP-1␤ (31,32) in various human cell lines, but to date there have been no studies of DV-induced chemokine expression in vivo. We therefore conducted an in vivo study using mice as an animal model to investigate the induction of chemokines and their functions following DV infection.…”
mentioning
confidence: 99%