Activation of T Lymphocytes as a Novel Mechanism in Beta1-Adrenergic Receptor Autoantibody-Induced Cardiac Remodeling—Additional Information About TLR9 Involvement

Haberland, Annekathrin; Müller, Johannes; Wenzel, Katrin

doi:10.1007/s10557-019-06874-0

Cited by 1 publication

(1 citation statement)

References 11 publications

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“…Although the mechanism of initiation of antibody formation is unknown, activated toll-like receptor 9 might explain the link that connects innate and adaptive immunity. 21,22 In DCM, β 1 -AR autoantibody titers are associated with the risk of ventricular tachycardia and sudden death. 23 Störk et al have also shown that β 1 -AR antibody titer predicts all-cause and cardiac mortality among patients with idiopathic cardiomyopathy.…”

Section: β 1 -Adrenoreceptor Autoantibodies In Hfmentioning

confidence: 99%

β ₁ -Adrenoreceptor Autoantibodies in Heart Failure

Düngen

Đorđević

Felix

et al. 2020

Circ: Heart Failure

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Antibodies that activate the β 1 -AR (β 1 -adrenoreceptor) can induce heart failure in animal models. These antibodies are often found in patients with heart failure secondary to varying etiologies. Their binding to the β 1 receptor leads to prolonged receptor activation with subsequent induction of cellular dysfunction, apoptosis, and arrhythmias. β-blocker therapy while highly effective for heart failure, may not be sufficient treatment for patients who have β 1 receptor autoantibodies. Removal of these autoantibodies by immunoadsorption has been shown to improve heart failure in small studies. However, immunoadsorption is costly, time consuming, and carries potential risks. An alternative to immunoadsorption is neutralization of autoantibodies through the intravenous application of small soluble molecules, such as peptides or aptamers, which specifically target and neutralize β 1 -AR autoantibodies. Peptides may induce immunogenicity. Animal as well as early phase human studies with aptamers have not shown safety concerns to date and have demonstrated effectiveness in reducing autoantibody levels. Novel aptamers have the potential advantage of having a wide spectrum of action, neutralizing a variety of known circulating G-protein coupled receptor autoantibodies. These aptamers, therefore, have the potential to be novel therapeutic option for patients with heart failure who have positive for β 1 -AR autoantibodies. However, clinical outcomes trials are needed to assess the clinical utility of this novel approach to treat heart failure.

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Section: β 1 -Adrenoreceptor Autoantibodies In Hfmentioning

confidence: 99%