Activation of SIRT-1 Signalling in the Prevention of Bipolar Disorder and Related Neurocomplications: Target Activators and Influences on Neurological Dysfunctions

Icariin prevents methylmercury-induced experimental neurotoxicity: Evidence from cerebrospinal fluid, blood plasma, brain samples, and in-silico investigations

“…In the present investigation, we aimed to determine how icariin ‘s modification of these signaling pathways may impact the treatment of behavioral and neurochemical abnormalities in a Wistar rat model of ALS induced by MeHg+. Reducing the protein levels of SIRT-1, Nrf-2, and HO-1 in ALS rats by administering MeHg+ for 21 days resulted in multiple neurodegenerative complications [ 11 , 19 , 39 ]. Animal and cell studies show that MeHg+ administration accelerates ALS progression.…”

“…It regulates learning, memory, neurogenesis, inflammation, and ageing. Multiple studies have shown that inhibiting SIRT-1 affects neural plasticity, gene expression, mitochondrial dysfunction, and inflammation [ 11 , 12 ]. Decreased SIRT-1 function and associated causes are responsible for Alzheimer's disease (AD) [ 13 ], schizophrenia [ 14 ], Parkinson's disease (PD) [ 14 , 15 ], and multiple sclerosis (MS) [ 16 , 17 ].…”

Sirtuins and Melatonin: Linking Chronobiology to Inflammation and Aging

“…The enhancement of the SIRT1-PGC-1α pathway is another signaling route via which melatonin exerts its protective effects, this time mitochondria being the main target, as PGC-1α is known as the master mitochondrial regulator, increasing their biogenesis and function [26]. SIRT1 enhancement by melatonin as a secondary signaling pathway [89] could correct some of the oxidative, mitochondrial, and neurotransmitter imbalances characteristic for depression and other neuropsychiatric disorders [102,103], and contribute to uncovering more of the cellular pathways involved in melatonin's antidepressant-like effect [104,105].…”