Activation of STING signaling aggravates chronic alcohol exposure‐induced cognitive impairment by increasing neuroinflammation and mitochondrial apoptosis
Xinrou Lin,
Xiangpen Li,
Chenguang Li
et al.
Abstract:AimsChronic alcohol exposure leads to persistent neurological disorders, which are mainly attributed to neuroinflammation and apoptosis. Stimulator of IFN genes (STING) is essential in the cytosolic DNA sensing pathway and is involved in inflammation and cellular death processes. This study was to examine the expression pattern and biological functions of STING signaling in alcohol use disorder (AUD).MethodsCell‐free DNA was extracted from human and mouse plasma. C57BL/6J mice were given alcohol by gavage for … Show more
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