Activation of reward circuitry in human opiate addicts

Sell, Louise; Morris, John; Bearn, Jenny; Frackowiak, R. S. J.; Friston, Karl J.; Dolan, Raymond J.

doi:10.1046/j.1460-9568.1999.00522.x

Cited by 133 publications

(66 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is methodologically difficult if not impossible to eliminate this problem, and the observed pattern therefore remains ambiguous; however, there is clearly no support here for the alternative view that abstinence actually heightens cue reactivity by enhancing cue salience. The present findings are consistent with other reports that prior nicotine administration sensitizes subjective responses to cocaine-related cues (e.g., Reid et al 1998) and that heroin addicts show greater relative activation of prefrontal cortex and amygdala during exposure to heroin-related cues immediately following administration (under double-blind conditions) of an intravenous dose of heroin rather than placebo (Sell et al 1999).…”

Section: Discussionsupporting

confidence: 92%

Smoking, reward responsiveness, and response inhibition: tests of an incentive motivational model

Powell

Dawkins

Davis

2002

Biological Psychiatry

126

114

View full text Add to dashboard Cite

Background: Incentive-motivation models of addiction suggest impairment of functional activity in mesocorticolimbic reward pathways during abstinence. This study tested implications for subjective and behavioral responses to nondrug incentives, cue-elicited craving, and prefrontal cognitive functions, particularly response inhibition. Methods:We tested 26 smokers after smoking and after overnight abstinence in counterbalanced order; 26 nonsmokers were also tested twice. Measures included a simple card-sorting test performed with and without financial incentive (the CARROT), the Snaith Hamilton Pleasure Scale as an index of subjective reward responsiveness, ratings of subjective craving and withdrawal before and after exposure to a cigarette, an index of oculomotor response inhibition (saccadic vs. antisaccadic eye movements), verbal fluency, and reversed digit span. Results:Compared with the smoking condition, and independently of withdrawal severity, abstinence was associated with reduced cue reactivity, pleasure expectancies, responsiveness to financial incentive, and response inhibition (antisaccadic eye movements). Verbal fluency and reversed digit span were unaffected, contrary to findings elsewhere with heavier smokers. Nonsmokers' scores either fell between those of abstainers and recent smokers or approximated those of recent smokers. Conclusions:The data were in general consistent with behavioral predictions derived from the incentive-motivational model of addiction and suggest that abstinence may be associated with impairments of motivation and response inhibition, which are independent of other subjectively experienced withdrawal symptoms.

show abstract

Section: Discussionsupporting

confidence: 92%

Smoking, reward responsiveness, and response inhibition: tests of an incentive motivational model

Powell

Dawkins

Davis

2002

Biological Psychiatry

126

114

View full text Add to dashboard Cite

show abstract

“…Subsequent studies noted cerebellar activity during cocaine craving (Kilts et al, 2001;Bonson et al, 2002), during recall or imagery of cocaine-use experiences (Wang et al, 1999;Kilts et al, 2001), and during stimulant expectancy (Volkow et al, 2003). Acute administration of or cues for other stimulants or psychoactive drugs also has been associated with increased cerebellar activity (Volkow et al, 1996(Volkow et al, , 1988London et al, 1990;Ghatan et al, 1998;Sell et al, 1999;Domino et al, 2000). Two studies reported cerebellar midline (vermis) activation by alcohol odor cues and by stimulant expectancy (Schneider et al, 2001;Volkow et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Cerebellar Vermis Involvement in Cocaine-Related Behaviors

Anderson

Maas

Frederick

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

Although the cerebellum is increasingly being viewed as a brain area involved in cognition, it typically is excluded from circuitry considered to mediate stimulant-associated behaviors since it is low in dopamine. Yet, the primate cerebellar vermis (lobules II-III and VIII-IX) has been reported to contain axonal dopamine transporter immunoreactivity (DAT-IR). We hypothesized that DAT-IR-containing vermis areas would be activated in cocaine abusers by cocaine-related cues and, in healthy humans, would accumulate DAT-selective ligands. We used BOLD fMRI to determine whether cocaine-related cues activated DAT-IR-enriched vermis regions in cocaine abusers and positron emission tomography imaging of healthy humans to determine whether the DAT-selective ligand [ 11 C]altropane accumulated in those vermis regions. Cocaine-related cues selectively induced BOLD activation in lobules II-III and VIII-IX in cocaine users, and, at early time points after ligand administration, we found appreciable [ 11 C]altropane accumulation in lobules VIII-IX, possibly indicating DAT presence in this region. These data suggest that parts of cerebellar vermis mediate cocaine's persisting and acute effects. In light of prior findings illustrating vermis connections to midbrain dopamine cell body regions, established roles for the vermis as a locus of sensorimotor integration and motor planning, and findings of increased vermis activation in substance abusers during reward-related and other cognitive tasks, we propose that the vermis be considered one of the structures involved in cocaine-and other incentive-related behaviors.

show abstract

“…Intense craving for the drug is a fundamental feature of addiction and is thought to trigger drug use and relapse. Environmental cues associated with drug taking behavior are potent stimulators of opiate craving in humans (Childress et al, 1986;Sell et al, 1999). A better understanding of brain mechanisms involved in producing drug craving would lead to better treatments for drug addiction.…”

Section: Introductionmentioning

confidence: 99%

“…Human brain imaging studies have shown that drugassociated cues strongly activate the anterior cingulate cortex (Cg), the amygdala and other basal forebrain regions (Childress et al, 1999;Sell et al, 1999). Environments associated with drug taking can strongly motivate drugseeking behavior in human addicts (Childress et al, 1986;Wallace, 1989) and the conditioned place preference (CPP) paradigm is an animal model of this type of cue-elicited conditioning (Bardo et al, 1995;Tzschentke, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…The brain areas analyzed for this study were the anterior Cg, nucleus accumbens, bed nucleus of the stria terminalis (BNST), and amygdala. The Cg is an area consistently activated by drug cues in human cocaine and heroin addicts (Childress et al, 1999;Sell et al, 1999), and has been shown to be important for learning to associate environmental stimuli with cocaine administration in animals (Weissenborn et al, 1997). Although the basolateral amygdala is not necessary for the acquisition of cueinduced heroin seeking (Alderson et al, 2000), this area is important for cue-induced reinstatement of extinguished heroin-seeking behavior (Fuchs and See, 2002).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Enhanced Morphine Preference Following Prolonged Abstinence: Association with Increased Fos Expression in the Extended Amygdala

Harris

Aston‐Jones

2003

Neuropsychopharmacol

View full text Add to dashboard Cite

We previously found that chronically morphine-pretreated, abstinent rats show stronger preferences for morphine-associated environments than placebo-pretreated rats. Here we show that this increased preference persisted for at least 5 weeks after withdrawal of chronic morphine. To determine brain regions involved in this behavior, we examined neural activation (as indexed by Fos-like proteins) induced by a morphine-conditioned place preference test. Placebo-pretreated (P) morphine-conditioned rats showed significantly elevated Fos in the anterior cingulate cortex (Cg), nucleus accumbens core (Ac-C) and shell (Ac-S), ventral lateral and dorsal lateral bed nucleus of the stria terminialis (BNST-VL and -DL), and central and basolateral amygdala nuclei (ACE, ABL) when compared to nonconditioned P rats. Chronically morphine-pretreated (M) rats that exhibited enhanced morphine preference 5 weeks after morphine withdrawal showed significantly greater Fos in all the same areas except the BNST-DL relative to conditioned P or nonconditioned M rats. Place preference measures and Fos expression were positively correlated in the Cg and ABL, for conditioned P animals, and in the Cg, ABL and BNST-VL for conditioned M animals. These results indicate a relationship between place preference behavior and neural indices of activation in the forebrain in response to morphine-conditioned cues that may be chronically modulated by prior morphine exposure.

show abstract

Activation of reward circuitry in human opiate addicts

Cited by 133 publications

References 42 publications

Smoking, reward responsiveness, and response inhibition: tests of an incentive motivational model

Smoking, reward responsiveness, and response inhibition: tests of an incentive motivational model

Cerebellar Vermis Involvement in Cocaine-Related Behaviors

Enhanced Morphine Preference Following Prolonged Abstinence: Association with Increased Fos Expression in the Extended Amygdala

Contact Info

Product

Resources

About