Activation of renshaw cells

Windhorst, U.

doi:10.1016/0301-0082(90)90020-h

Cited by 58 publications

(44 citation statements)

References 124 publications

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“…For Renshaw cells, these values were adapted so that the membrane time constant could make the cell fire a burst of action potentials in response to a supra-threshold input (Hultborn and Pierrot-Deseilligny 1979). The values of parameters such as rate constants and peak conductances (for default values, see V-d conductances panel in the Configuration module of the simulator) were determined so that the AHP, the f×I relation and the generation of action potential bursts followed data from the literature (Hultborn and Pierrot-Deseilligny 1979;Cleveland et al 1981;Walmsley and Tracey 1981;Windhorst 1990;Windhorst 1996;Uchiyama et al 2003). Parameters related to the IaIn and IbIn interneuron conductances were chosen so that these interneurons would fire isolated action potentials in response to a volley coming from the sensory afferents (Jankowska 1992).…”

Section: Motoneuron and Interneuron Modelsmentioning

confidence: 99%

Simulation system of spinal cord motor nuclei and associated nerves and muscles, in a Web-based architecture

2008

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Section: Motoneuron and Interneuron Modelsmentioning

confidence: 99%

Simulation system of spinal cord motor nuclei and associated nerves and muscles, in a Web-based architecture

2008

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“…However, RCs receive long-lasting cholinergic EPSPs from motor axons and display unusual low thresholds for action potential generation. These peculiarities result in the characteristic tendency of RCs to discharge bursts of spikes in response to incoming motor axon volleys, even when only one action potential travels down a single motor axon (for review, see Windhorst, 1990). Modulation of RC activity therefore requires complementary well-matched inhibition.…”

Section: Inhibitory Modulation Of Rc Functionmentioning

confidence: 99%

Differential Postnatal Maturation of GABA_A, Glycine Receptor, and Mixed Synaptic Currents in Renshaw Cells and Ventral Spinal Interneurons

González-Forero

Álvarez

2005

J. Neurosci.

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Renshaw cells (RCs) receive excitatory inputs from motoneurons to which then they inhibit. The gain of this spinal recurrent inhibitory circuit is modulated by inhibitory synapses on RCs. Inhibitory synapses on RCs mature postnatally, developing unusually large postsynaptic gephyrin clusters that colocalize glycine and GABA A receptors. We hypothesized that these features potentiate inhibitory currents in RCs. Thus, we analyzed glycinergic and GABAergic "inhibitory" miniature postsynaptic currents (mPSCs) in neonatal [postnatal day 1 (P1) to P5] and mature (P9 -P15) RCs and compared them to other ventral interneurons (non-RCs). Recorded neurons were Neurobiotin filled and identified as RCs or non-RCs using post hoc immunohistochemical criteria. Glycinergic, GABAergic, and mixed glycine/ GABA mPSCs matured differently in RCs and non-RCs. In RCs, glycinergic and GABA A mPSC peak amplitudes increased 230 and 45%, respectively, from P1-P5 to P9 -P15, whereas in non-RCs, glycinergic peak amplitudes changed little and GABA A amplitudes decreased. GABA A mPSCs were slower in RCs (P1-P5, ϭ 58 ms; P9 -P15, ϭ 43 ms) compared with non-RCs (P1-P5, ϭ 27 ms; P9 -P15, ϭ 14 ms). Thus, fast glycinergic currents dominated "mixed" mPSC peak amplitudes in mature RCs, and GABA A currents dominated their long decays. In non-RCs, GABAergic and mixed events had shorter durations, and their frequencies decreased with development. Functional maturation of inhibitory synapses on RCs correlates well with increased glycine receptor recruitment to large gephyrin patches, colocalization with ␣3/␣5-containing GABA A receptors, and maintenance of GABA/glycine corelease. As a result, charge transfer in GABA, glycine, or mixed mPSCs was larger in mature RCs than in non-RCs, suggesting RCs receive potent inhibitory synapses.

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“…These neuronal oscillatory networks have been investigated in both vertebrate and invertebrate preparations, and shared principles of organization have emerged. For example, there is increasing evidence from both mammalian (Windhorst, 1990) and nonmammalian vertebrate systems (Perrins and Roberts, 1995a,b) that motoneurons may have a dynamic role in contributing to the patterned output through central feedback pathways to C PG interneurons. In some invertebrate C PGs, which are thought to serve as usef ul general models for rhythmically active neuronal networks, motoneurons have been demonstrated to make a similarly active contribution to patterned output.…”

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confidence: 99%

Pattern-Generating Role for Motoneurons in a Rhythmically Active Neuronal Network

1998

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The role of motoneurons in central motor pattern generation was investigated in the feeding system of the pond snail Lymnaea stagnalis, an important invertebrate model of behavioral rhythm generation. The neuronal network responsible for the three-phase feeding motor program (fictive feeding) has been characterized extensively and divided into populations of central pattern generator (CPG) interneurons, modulatory interneurons, and motoneurons. A previous model of the feeding system considered that the motoneurons were passive followers of CPG interneuronal activity. Here we present new, detailed physiological evidence that motoneurons that innervate the musculature of the feeding apparatus have significant electrotonic motoneuron3interneuron connections, mainly confined to cells active in the same phase of the feeding cycle (protraction, rasp, or swallow). This suggested that the motoneurons participate in rhythm generation. This was assessed by manipulating firing activity in the motoneurons during maintained fictive feeding rhythms. Experiments showed that motoneurons contribute to the maintenance and phase setting of the feeding rhythm and provide an efficient system for phase-locking muscle activity with central neural activity. These data indicate that the distinction between motoneurons and interneurons in a complex CNS network like that involved in snail feeding is no longer justified and that both cell types are important in motor pattern generation. This is a distributed type of organization likely to be a general characteristic of CNS circuitries that produce rhythmic motor behavior.

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Activation of renshaw cells

Cited by 58 publications

References 124 publications

Simulation system of spinal cord motor nuclei and associated nerves and muscles, in a Web-based architecture

Simulation system of spinal cord motor nuclei and associated nerves and muscles, in a Web-based architecture

Differential Postnatal Maturation of GABA_A, Glycine Receptor, and Mixed Synaptic Currents in Renshaw Cells and Ventral Spinal Interneurons

Pattern-Generating Role for Motoneurons in a Rhythmically Active Neuronal Network

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Activation of renshaw cells

Cited by 58 publications

References 124 publications

Simulation system of spinal cord motor nuclei and associated nerves and muscles, in a Web-based architecture

Simulation system of spinal cord motor nuclei and associated nerves and muscles, in a Web-based architecture

Differential Postnatal Maturation of GABAA, Glycine Receptor, and Mixed Synaptic Currents in Renshaw Cells and Ventral Spinal Interneurons

Pattern-Generating Role for Motoneurons in a Rhythmically Active Neuronal Network

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Differential Postnatal Maturation of GABA_A, Glycine Receptor, and Mixed Synaptic Currents in Renshaw Cells and Ventral Spinal Interneurons