Activation of renal haeme oxygenase-1 alleviates gentamicin-induced acute nephrotoxicity in rats

Taye, Ashraf; Ibrahim, Badr Mostafa

doi:10.1111/jphp.12067

Cited by 17 publications

(13 citation statements)

References 53 publications

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“…Taye et al obtained contrary results, demonstrating that ZnPP abolished the renoprotective effect of HO-1 in this model. They found HO induction decreased inflammatory markers in the kidney, conferring protection (133). These studies indicate heterogeneity in the gentamycin model of AKI.…”

Section: Ho-1 In Kidney Health and Diseasementioning

confidence: 93%

Heme Oxygenase-1 in Kidney Health and Disease

Lever

Boddu

George

et al. 2016

Antioxidants & Redox Signaling

115

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Section: Ho-1 In Kidney Health and Diseasementioning

confidence: 93%

Heme Oxygenase-1 in Kidney Health and Disease

Lever

Boddu

George

et al. 2016

Antioxidants & Redox Signaling

115

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“…[8][9][10] Antioxidant and antioxidative enzyme activities reduce due to GM or increase of lipid peroxidation products. 11 Most research studies against GM -induced nephrotoxicity are focused on the use of various anti-oxidants. 12 A number of natural antioxidant such as vitamin E and phenolic compounds are known to have protective effects on liver injury and nephrotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Serum paraoxonase 1 status and its association with atherogenic indexes in gentamicin-induced nephrotoxicity in rats treated with coenzyme Q10

et al. 2013

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Coenzyme Q10 is a natural antioxidant and scavenger of free radicals. In the present study, we examined the effect of coenzyme Q10 on paraoxonase 1 (PON1) activity, lipid profile, atherogenic indexes and relationship of PON 1 activity by high-density lipoprotein (HDL) and atherogenic indexes in gentamicin (GM)-induced nephrotoxicity rats. Thirty Sprague-Dawley rats were divided into three groups to receive saline; GM, 100 mg/kg/d; and GM plus coenzyme Q10 by 15 mg/kg i.p daily, respectively. After 12 days, animals were anaesthetized, blood samples were also collected before killing to measure the levels of triglyceride (TG), cholesterol (C), low-density lipoprotein (LDL), very low density lipoprotein (VLDL), HDL, atherogenic indexes and the activities of PON1 of all groups were analyzed. Data were analyzed by non-parametric Mann-Whitney test (using SPSS 13 software). Coenzyme Q10 significantly decreased TG, C, LDL, VLDL, atherogenic index, atherogenic coefficient and cardiac risk ratio. HDL level and PON1 activity were significantly increased when treated with coenzyme Q10. Also, the activity of PON 1 correlated positively with HDL and negatively with atherogenic coefficient, cardiac risk ratio 1 and cardiac risk ratio 2. This study showed that coenzyme Q10 exerts beneficial effects on PON1 activity, lipid profile, atherogenic index and correlation of PON 1 activity with HDL and atherogenic index in GM -induced nephrotoxicity rats.

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“…The activities of caspase-3 and caspase-9 in the kidney were determined using commercial kits (Beyotime Bioengineering Institute Beijing, China). Total HO-1 activity was measured as described previously (41). In brief, reactions were performed in a 1.2-ml reaction mixture consisting of 0.5 mg protein from tissue homogenate, 2 mmol/liter glucose-6-phosphate, 0.2 U glucose-6-phosphate dehydrogenase, 0.8 mmol/liter NADP, and 20.0 mmol/liter hemin.…”

Section: Histopathological Examinationmentioning

confidence: 99%

Lycopene Attenuates Colistin-Induced Nephrotoxicity in Mice via Activation of the Nrf2/HO-1 Pathway

Dai

Tang

Deng

et al. 2015

Antimicrob Agents Chemother

103

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bNephrotoxicity is the major dose-limiting factor for the clinical use of colistin against multidrug-resistant (MDR) Gram-negative bacteria. This study aimed to investigate the protective effect of lycopene on colistin-induced nephrotoxicity in a mouse model. Fifty mice were randomly divided into 5 groups: the control group (saline solution), the lycopene group (20 mg/kg of body weight/day administered orally), the colistin group (15 mg/kg/day administered intravenously), the colistin (15 mg/kg/day) plus lycopene (5 mg/kg/day) group, and the colistin (15 mg/kg/day) plus lycopene (20 mg/kg/day) group; all mice were treated for 7 days. At 12 h after the last dose, blood was collected for measurements of blood urea nitrogen (BUN) and serum creatinine levels. The kidney tissue samples were obtained for examination of biomarkers of oxidative stress and apoptosis, histopathological assessment, and quantitative reverse transcription-PCR (qRT-PCR) analysis. Colistin treatment significantly increased concentrations of BUN and serum creatinine, tubular apoptosis/necrosis, lipid peroxidation, and heme oxygenase 1 (HO-1) activity, while the treatment decreased the levels of endogenous antioxidant biomarkers glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD). Notably, the changes in the levels of all biomarkers were attenuated in the kidneys of mice treated with colistin by lycopene (5 or 20 mg/kg). Lycopene treatment, especially in the colistin plus lycopene (20 mg/kg) group, significantly downregulated the expression of NF-B mRNA (P < 0.01) but upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both P < 0.01) in the kidney compared with the results seen with the colistin group. Our data demonstrated that coadministration of 20 mg/kg/day lycopene can protect against colistin-induced nephrotoxicity in mice. This effect may be attributed to the antioxidative property of lycopene and its ability to activate the Nrf2/HO-1 pathway.

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Activation of renal haeme oxygenase-1 alleviates gentamicin-induced acute nephrotoxicity in rats

Abstract: Here is the first evidence demonstrating the protective effect of HO-1 against gentamicin-associated nephrotoxicity. Suppression of oxidative/inflammatory insults alongside the corresponding decline of apoptosis were presumably responsible for this renoprotection.

Cited by 17 publications

References 53 publications

Heme Oxygenase-1 in Kidney Health and Disease

Heme Oxygenase-1 in Kidney Health and Disease

Serum paraoxonase 1 status and its association with atherogenic indexes in gentamicin-induced nephrotoxicity in rats treated with coenzyme Q10

Lycopene Attenuates Colistin-Induced Nephrotoxicity in Mice via Activation of the Nrf2/HO-1 Pathway

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