Activation of pyroptosis and ferroptosis is involved in the hepatotoxicity induced by polystyrene microplastics in mice

Mu, Yingwen; Sun, J.; Li, Ziyuan; Zhang, Wanxin; Liu, Zuodong; Li, Chao; Peng, Cheng; Cui, Guanqun; Shao, Hua; Du, Zhongjun

doi:10.1016/j.chemosphere.2021.132944

Cited by 91 publications

(33 citation statements)

References 58 publications

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“…A variety of models have been reported over the past decade in which ferroptosis is activated during organ injury (Stockwell et al, 2017; Figure 3). Recently, 5 mm microplastics were found to induce markers of ferroptosis in mouse liver (Mu et al, 2022), and 2.5 mm particulate matter (PM2.5) was reported to induce ferroptosis in mouse lung (Guohua et al, 2021); ferroptosis was found to cause defective kidney repair and the formation of inflammatory proximal tubular cells (Ide et al, 2021). In addition, the vascular leakage that occurs during sepsis, which can result in injury of multiple organs, is associated with gene expression, metabolomic changes, and markers characteristic of ferroptosis (She et al, 2021).…”

Section: Organ Injurymentioning

confidence: 99%

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Stockwell

2022

Cell

853

422

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Section: Organ Injurymentioning

confidence: 99%

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Stockwell

2022

Cell

853

422

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“…Our results demonstrated that exposure to MPs leads to an increased expression of NFkB, MyD88 and NLRP3, suggesting that MPs could contribute to inducing the intracellular inflammation process [63]. NLRP3 inflammasome is the active center for regulation of the cellular inflammatory response [64][65][66].…”

Section: Discussionmentioning

confidence: 66%

“…The protein molecular expression and gene expression trends in this study are consistent with the qualitative data obtained by immunofluorescence experiments. Oxidative stress and pro-inflammatory processes were considered to be interdependent, but many studies have shown that oxidative stress can induce inflammatory responses and the release of many chemokines [64,67]. Environmental toxicants showed deleterious effects on female reproduction in utero, in the neonatal and prepubertal periods and in adulthood [68].…”

Section: Discussionmentioning

confidence: 99%

Microplastics Affect the Inflammation Pathway in Human Gingival Fibroblasts: A Study in the Adriatic Sea

Caputi

Diomede

Lanuti

et al. 2022

IJERPH

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The level of environmental microplastics in the sea is constantly increasing. They can enter the human body with food, be absorbed through the gut and have negative effects on the organism’s health after its digestion. To date, microplastics (MPs) are considered new environmental pollutants in the air sea and they are attracting wide attention. The possible toxic effects of MPs isolated at different sea depths of 1, 24 and 78 m were explored in an in vitro model of human gingival fibroblasts (hGFs). MPs isolated from the sea showed different size and were then divided into different sample groups: 1, 24 and 78 m. The results obtained revealed that MPs are able to activate the inflammatory pathway NFkB/MyD88/NLRP3. In detail, the exposure to MPs from 1 and 78 m led to increased levels of inflammatory markers NFkB, MyD88 and NLRP3 in terms of proteins and gene expression. Moreover, cells exposed to MPs showed a lower metabolic activity rate compared to unexposed cells. In conclusion, these findings demonstrate that the inflammation process is stimulated by MPs exposure, providing a new perspective to better understand the intracellular mechanism.

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Section: Discussionmentioning

confidence: 99%

“…With respect to increased plasma levels of MDA and decreased plasma SOD levels in lipid peroxidation, microplastics (MPs) are known as environmental pollutants and induce lipid peroxidation [41]. MPs induce in ammasomes and apoptosis in liver tissue by increased oxidative stress, resulting in increase of MDA and decrease of SOD in the liver [41]. A former clinical study reported that elevated plasma MDA levels and decreased plasma SOD levels in the 17 patients with neck squamous cell carcinoma due to elevated lipid peroxidation [42].…”

Section: Discussionmentioning

confidence: 99%

Contribution of lipid Peroxidation to Social Behaviors in individuals with autism spectrum disorders

Yui

Imataka

Hayashi

et al. 2022

Preprint

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Lipid peroxidation contributes to the development of autism spectrum disorders (ASD). Omega-3 and omega-6 polyunsaturated fatty acids undergo lipid peroxidation, and conversion to malondialdehyde (MDA). The MDA further react with acetaldehyde to form malondialdehyde-modified low-density lipoprotein (MDA-LDL). MDA-LDL is known as a marker of lipid peroxidation. However, the association between PUFAs and MDA-LDL in the pathophysiology of ASD is unclear. We studied this association in 18 young individuals with ASD and 8 age- and sex-matched normal healthy controls. Social behaviors were assessed using the Social Responsiveness Scale (SRS). To overcome the small sample size, three measures were conducted: firstly, use of adaptive Lasso for enhancing the accuracy of prediction and interpretability; second, estimation of coefficient of variation for an appropriate variable selection; and finally, appropriate variables were selected. Plasma MDA levels and DHA/omega 6 PUFA arachidonic acid ratio were significantly higher, whereas plasma levels of superoxide dismutase were significantly lower in the ASD group than in the control group. Total SRS scores were significantly higher in the ASD group than in the control group. Multiple linear regression and adaptive Lasso revealed that plasma DHA/ARA ratio were significantly associated with total SRS scores. Plasma levels of the antioxidant enzyme superoxide dismutase were significantly decreased and plasma MDA-LDL levels were significantly increased. These findings firstly revealed that the plasma DHA/ARA ratio may be associated with social behaviors. Decreased plasma SOD levels and increased plasma MDA-LDL levels may be caused in relation to lipid peroxidation. These neurological bases may contribution to social impairment.

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Activation of pyroptosis and ferroptosis is involved in the hepatotoxicity induced by polystyrene microplastics in mice

Cited by 91 publications

References 58 publications

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Microplastics Affect the Inflammation Pathway in Human Gingival Fibroblasts: A Study in the Adriatic Sea

Contribution of lipid Peroxidation to Social Behaviors in individuals with autism spectrum disorders

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