2004
DOI: 10.1213/01.ane.0000131506.38512.7c
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Activation of Protein Kinase C Contributes to the Isoflurane-Induced Improvement of Functional and Metabolic Recovery in Isolated Ischemic Rat Hearts

Abstract: Isoflurane enhances myocardial functional recovery and improves energy levels after ischemia. We sought to determine whether isoflurane-induced cardioprotection is mediated by protein kinase C (PKC). The Langendorff model was used, and isolated perfused rat hearts were separated into untreated, isoflurane, chelerythrine (PKC inhibitor) plus isoflurane, and chelerythrine groups. All hearts were subjected to treatment before ischemia, followed by 30 min of ischemia and 60 min of reperfusion. We recorded hemodyna… Show more

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Cited by 16 publications
(13 citation statements)
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References 28 publications
(21 reference statements)
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“…In the present study, the decrease in ATP and increase in LA contents were observed in ventricular myocardium of isoproterenol-damaged SD rats, as well as the decrease in energy charge (EC), which is indicative of cell's ability to perform anabolic processes (Xu et al, 2004). It suggested that oxygen shortage in myocardium was induced by isoproterenol stimulation, whereafter, the decrease in ATP synthesis resulted from destroyed aerobicoxidation and increase in LA contents from activated anaerobic metabolism.…”
Section: Discussionsupporting
confidence: 51%
“…In the present study, the decrease in ATP and increase in LA contents were observed in ventricular myocardium of isoproterenol-damaged SD rats, as well as the decrease in energy charge (EC), which is indicative of cell's ability to perform anabolic processes (Xu et al, 2004). It suggested that oxygen shortage in myocardium was induced by isoproterenol stimulation, whereafter, the decrease in ATP synthesis resulted from destroyed aerobicoxidation and increase in LA contents from activated anaerobic metabolism.…”
Section: Discussionsupporting
confidence: 51%
“…The disparities between APC and DNP in the extent of cell protection may imply additional mechanism of protection by APC. For example, APC involves multiple protective pathways, such as activation of antiapoptotic proteins (43), sarcolemmal K ϩ channels (34), and protein kinase C (54), that may exert additional cardioprotective effects independent of changes in ⌬⌿ m . Moreover, APC and the uncoupler DNP may not share the same mechanism to induce mitochondrial depolarization, as discussed above.…”
Section: Discussionmentioning
confidence: 99%
“…Importantly, PKC( is activated not only by a preconditioning stimulus, but also by treatments that mimic preconditioning such as adenosine [35], nitric oxide (NO˙) [36], volatile anaesthetics [12,13,16,37], and exogenously applied PKC( agonists [38]. Interestingly, many of these same triggers (adenosine, NO˙) and signals (survival kinases and anti-apoptotic enzymes) that are implicated in preconditioning and the activation of PKC( have also been identified to play a role in postconditioning [2 -5,19,21,39].…”
Section: Evidence For a Role Of Pkce Activation In Postconditioning Cmentioning
confidence: 99%