Activation of Protease-Activated Receptor-2 (PAR-2) Triggers Mucin Secretion in the Rat Sublingual Gland

The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection

“…Recent studies have suggested that PAR-2 triggers secretion of saliva including amylase and mucin in salivary glands (10,31) and of pancreatic juice including amylase in the pancreas (10)(11)(12). The PAR-2-mediated gastric mucus secretion observed in the present study supports our previous hypothesis that PAR-2 may play a general or key role in regulation of digestive exocrine secretion (10).…”

“…Capsaicin completely abolished the PAR-2-mediated gastric mucus secretion, while it had no effect on the misoprostol-induced mucus secretion (Figure 2b), strongly suggesting involvement of activation of the capsaicin-sensitive neurons. On the other hand, salivation and secretion of proteins (amylase and mucus) from salivary glands in response to PAR-2 activation that we reported recently (10,31) were not abolished by capsaicin ( Table 1).…”

Role of Protease-activated Receptors in the Vascular System

“…We observed that trypsin induced a transient [Ca 2+ ]i elevation mainly due to Ca 2+ release in the vascular endothelial cells (73). PAR-2 was also reported to activate mitogen-activated protein kinase (74)(75)(76), protein-tyrosine phosphatase SHP2 (77) and tyrosine kinase pathways (78), which could contribute to PAR-2-mediated cytokine production (74), mitogenic signaling (77) and mucin secretion in the rat sublingual gland (78).…”

Epithelial effects of proteinase-activated receptors in the gastrointestinal tract

“…Activation of PAR-2 has been shown to stimulate the secretion of mucin in a non-cholinergic, non-adrenergic and tyrosine kinasedependent manner (Kawabata et al 2000a). In addition, activation of PAR-2 in vivo stimulates the secretion of salivary amylase through a mechanism that does not involve capsaicin-sensitive nerves .…”