Activation of presynaptic oxytocin receptors enhances glutamate release in the ventral hippocampus of prenatally restraint stressed rats

Mairesse, Jérôme; Gatta, Eleonora; Reynaert, Marie Line; Marrocco, Jordan; Morley‐Fletcher, Sara; Soichot, Marion; Deruyter, Lucie; Camp, Gilles Van; Bouwalerh, Hammou; Fagioli, Francesca; Pittaluga, Anna; Allorge, Delphine; Nicoletti, Ferdinando; Maccari, Stefania

doi:10.1016/j.psyneuen.2015.07.005

Cited by 51 publications

(39 citation statements)

References 59 publications

(72 reference statements)

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“…An increasing body of evidence indicates that prenatal restraint stress can affect brain development and may be involved in the pathogenesis of depression [33,34]. Our previous works also supported that PRS can induce depressive-like behavior using SPT, FST, open field test (OFT) and tail suspension test (TST) [31,35,36,29].…”

Section: Discussionsupporting

confidence: 62%

Antidepressant-like activity of icariin mediated by group I mGluRs in prenatally stressed offspring

Zhang

Sun

et al. 2017

Brain and Development

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Section: Discussionsupporting

confidence: 62%

Antidepressant-like activity of icariin mediated by group I mGluRs in prenatally stressed offspring

Zhang

Sun

et al. 2017

Brain and Development

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“…the OXT system, two hypothalamic systems of crucial importance during brain development: exposure to a series of unpredictable stresses during the final week of pregnancy (Lee et al, 2007), repeated restraint stress (Mairesse et al, 2015), or prenatal cocaine (Williams & Johns, 2014) induced in the offspring an elevation of CRH production concomitantly with reduced OXT levels in the hypothalamus. The role of this imbalance in the developmental programming of neuroinflammation remains to be clarified.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia

Mairesse

Zinni

Pansiot

et al. 2018

Glia

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Prematurity and fetal growth restriction (FGR) are frequent conditions associated with adverse neurocognitive outcomes. We have previously identified early deregulation of genes controlling neuroinflammation as a putative mechanism linking FGR and abnormal trajectory of the developing brain. While the oxytocin system was also found to be impaired following adverse perinatal events, its role in the modulation of neuroinflammation in the developing brain is still unknown. We used a double‐hit rat model of perinatal brain injury induced by gestational low protein diet (LPD) and potentiated by postnatal injections of subliminal doses of interleukin‐1β (IL1β) and a zebrafish model of neuroinflammation. Effects of the treatment with carbetocin, a selective, long lasting, and brain diffusible oxytocin receptor agonist, have been assessed using a combination of histological, molecular, and functional tools in vivo and in vitro. In the double‐hit model, white matter inflammation, deficient myelination, and behavioral deficits have been observed and the oxytocin system was impaired. Early postnatal supplementation with carbetocin alleviated microglial activation at both transcriptional and cellular levels and provided long‐term neuroprotection. The central anti‐inflammatory effects of carbetocin have been shown in vivo in rat pups and in a zebrafish model of early‐life neuroinflammation and reproduced in vitro on stimulated sorted primary microglial cell cultures from rats subjected to LPD. Carbetocin treatment was associated with beneficial effects on myelination, long‐term intrinsic brain connectivity and behavior. Targeting oxytocin signaling in the developing brain may be an effective approach to prevent neuroinflammation – induced brain damage of perinatal origin.

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“…The dorsal hippocampus performs primarily cognitive functions, whereas the ventral hippocampus relates to stress, emotions, and affect. For example in rats, lesions in the dorsal hippocampus caused spatial memory impairment in the radial arm maze, contrary to lesions in the ventral hippocampus (55), and stress-related genes were found expressed in the ventral hippocampus of prenatally stressed rats (56). Interestingly, ventral hippocampal afferents to the nucleus accumbens were also found regulating susceptibility to depression (57).…”

Section: Discussionmentioning

confidence: 99%

Oral sodium butyrate impacts brain metabolism and hippocampal neurogenesis, with limited effects on gut anatomy and function in pigs

et al. 2018

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Butyrate can improve gut functions, whereas histone deacetylase inhibitors might alleviate neurocognitive alterations. Our aim was to assess whether oral butyrate could modulate brain metabolism and plasticity and if this would relate to gut function. Sixteen pigs were subjected to sodium butyrate (SB) supplementation via beverage water or water only [control (C)]. All pigs had blood sampled after 2 and 3 wk of treatment, and were subjected to a brain positron emission tomography after 3 wk. Animals were euthanized after 4 wk to sample pancreas, intestine, and brain for gut physiology and anatomy measurements, as well as hippocampal histology, Ki67, and doublecortin (DCX) immunohistochemistry. SB compared with C treatment triggered basal brain glucose metabolism changes in the nucleus accumbens and hippocampus ( P = 0.003), increased hippocampal granular cell layer volume ( P = 0.006), and neurogenesis (Ki67: P = 0.026; DCX: P = 0.029). After 2 wk of treatment, plasma levels of glucose, insulin, lactate, glucagon-like peptide 1, and peptide tyrosine tyrosine remained unchanged. After 3 wk, plasma levels of lactate were lower in SB compared with C animals ( P = 0.028), with no difference for glucose and insulin. Butyrate intake impacted very little gut anatomy and function. These results demonstrate that oral SB impacted brain functions with little effects on the gut.-Val-Laillet, D., Guérin, S., Coquery, N., Nogret, I., Formal, M., Romé, V., Le Normand, L., Meurice, P., Randuineau, G., Guilloteau, P., Malbert, C.-H., Parnet, P., Lallès, J.-P., Segain, J.-P. Oral sodium butyrate impacts brain metabolism and hippocampal neurogenesis, with limited effects on gut anatomy and function in pigs.

show abstract

Activation of presynaptic oxytocin receptors enhances glutamate release in the ventral hippocampus of prenatally restraint stressed rats

Cited by 51 publications

References 59 publications

Antidepressant-like activity of icariin mediated by group I mGluRs in prenatally stressed offspring

Antidepressant-like activity of icariin mediated by group I mGluRs in prenatally stressed offspring

Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia

Oral sodium butyrate impacts brain metabolism and hippocampal neurogenesis, with limited effects on gut anatomy and function in pigs

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