“…TNF-α is secreted by corneal epithelial cells in response to an inflammatory stimulation caused by bacterial and viral infections (Minami et al, 2002;Kurpakus-Wheater et al, 2003;Bitko et al, 2004;Kumar et al, 2004). TNF-α-stimulated increases in K + channel activities are important for TNF-α-induced cellular effects in cortical neurons, kidney epithelial cells, hepatic cells and corneal epithelial cells (Houzen et al, 1997;Nietsch et al, 2000;Wei et al, 2003). TNF-α also induces mRNA expression of various K + channel types during a systemic inflammatory response as well as tumor cell proliferation in brain and cancer cells Vicente et al, 2003Vicente et al, ,2004.…”