Activation of post-synaptic 5-HT1A receptors in the dorsal hippocampus prevents learned helplessness development

Joca, Sâmia Regiane Lourenço; Padovan, Cláudia Maria; Guimarães, Francisco Silveira

doi:10.1016/s0006-8993(03)02943-3

Cited by 100 publications

(98 citation statements)

References 46 publications

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“…In our work, ARS significantly decreased ambulation and rearing and increased grooming response, lets on less exploratory, lack of interest and anxiety-like deportment, which are raw to the monoaminergic system, in accordance with the previous report [21]. Acute ICV administration of TIP39 did not alter the open-field exploratory activity significantly except ambulatory behavior compared to ARS rats, indicating that TIP39 improved the decreased locomotor activity, simply had no psychostimulant effects.…”

Section: Discussionsupporting

confidence: 92%

Neurochemical Assessment and Behavioral Role of Tuberoinfundibular Peptide-39 in Acute Restraint Stress-Induced Depression in Rats.

Sankar

Ramanathan²,

Venkatesh³

2018

Asian J Pharm Clin Res

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Objective: Tuberoinfundibular peptide of 39 (TIP39) is a potent agonist to the parathyroid hormone 2 receptor (PTH2R) abundantly expressed in brain. The current study focused to evaluate the role of TIP39 in acute restraint stress (ARS)-induced depression model. Methods:Rats were exposed to ARS for 2 h to establish the depression and then subjected to open field and forced swim test (OFT and FST). TIP39 (1 and 10 nmol/rat) and HYWH (1 nmol/rat) are a PTH2R antagonist which was infused through intracerebroventricular route. Diazepam (2 mg/kg, i.p) was utilized as reference standard. Results:The results depict ARS significantly diminished the TIP39 expression in cerebral regions and causes depression-like behavior. TIP39 significantly decreased the immobility period in FST. In the OFT, TIP39 significantly increased the ambulatory activity and did not alter the rearing and grooming activity in comparison to ARS group. After TIP39 treatment, plasma noradrenaline levels were significantly increased, whereas the serotonin levels were unaltered. The corticosterone levels also decreased significantly. In rat brain tissues, TIP39 significantly reversed the abnormalities in glutamate and gamma-aminobutyric acid (GABA) level by ARS induction. In contrast, HYWH-treated rats did not show any significant variations in the neurochemical and behavioral parameters in comparison to ARS rats. Conclusion:Our reports submitted that the primary evidence depicting the stimulation of TIP39 expression could modulate the monoaminergic, GABAergic, and glutaminergic release with the support of hypothalamic-pituitary-adrenal axis that can be produced an antidepressant-like effect evident with the interactive study.

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Section: Discussionsupporting

confidence: 92%

Neurochemical Assessment and Behavioral Role of Tuberoinfundibular Peptide-39 in Acute Restraint Stress-Induced Depression in Rats.

Sankar

Ramanathan²,

Venkatesh³

2018

Asian J Pharm Clin Res

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show abstract

“…Dados da literatura sugerem que a exposição a eventos estressantes é um dos principais fatores ambientais que antecede a depressão, pois em 60% dos casos a depressão é precedida por fatores estressantes, principalmente psicossociais (POST, 1992;JOCA et al, 2003).…”

Section: Etiologia Da Depressãounclassified

Papel da via Núcleo Mediano da Rafe-Hipocampo Dorsal nos efeitos antidepressivos do tratamento com Imipramina

Silva¹

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“…Para esse tipo de estudo os animais são expostos a choques escapáveis e sinalizados, após 24h do estressor e, neste contexto, são observados os déficits para fugir ou evitar esses choques (BHATIA et al, 2011;GUIMARÃES, 2003a;BEAGLEY, 1975). É bem estabelecido que a incontrolabilidade dos choques produza alterações fisiológicas além das alterações dos níveis centrais de alguns neurotransmissores (HUNZIKER, 2005).…”

Section: Guimarães 2003a)unclassified

“…Após a organização dos dados em BT, foi calculada a porcentagem de desamparo aprendido (%DA), sendo que para um animal ser considerado com desamparo aprendido este deveria apresentar número de falhas maior ou igual a 10 (falha ≥ 10) durante toda a seção de CI (JOCA; GUIMARÃES, 2003a Na figura 7 são mostradas as porcentagens de desamparo aprendido (%DA) em função aos tratamentos. Não houve efeito dos tratamentos para as porcentagens de desamparo aprendido no estudo 1 (² = 6,018; n = 55; gl = 3; p>0,05).…”

Section: Análise De Dadosunclassified

Papel dos receptores de glutamato do tipo NMDA localizados no Núcleo Mediano da Rafe na expressão do desamparo aprendido em ratos

Marques¹

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Activation of post-synaptic 5-HT1A receptors in the dorsal hippocampus prevents learned helplessness development

Cited by 100 publications

References 46 publications

Neurochemical Assessment and Behavioral Role of Tuberoinfundibular Peptide-39 in Acute Restraint Stress-Induced Depression in Rats.

Neurochemical Assessment and Behavioral Role of Tuberoinfundibular Peptide-39 in Acute Restraint Stress-Induced Depression in Rats.

Papel da via Núcleo Mediano da Rafe-Hipocampo Dorsal nos efeitos antidepressivos do tratamento com Imipramina

Papel dos receptores de glutamato do tipo NMDA localizados no Núcleo Mediano da Rafe na expressão do desamparo aprendido em ratos

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