Activation of plasma by contact with glass: evidence for a common reaction which releases plasma kinin and initiates coagulation

Margolis, J.

doi:10.1113/jphysiol.1958.sp006082

Cited by 249 publications

(101 citation statements)

References 18 publications

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“…The method for activation of y-globulins with glass is based on that described by Margolis (1958). Fresh guinea-pig serum was shaken for 2 min with glass ballotini (microspherules 0.1 mm in diameter), 1 g/ml.…”

Section: Methodsmentioning

confidence: 99%

“…Attempts to induce this conversion by the addition of various tissue extracts to freshly prepared fractions have so far been fruitless. Activation of guinea-pig y-globulins by ballotini treated with guinea-pig serum An alternative approach to the problem was suggested by the work of Margolis (1958) who investigated the release of kinin from human plasma by contact with glass. He postulated that glass adsorbs and activates Hageman factor and this in turn activates a component " A " which, together with a component " B," causes a release of kinin.…”

Section: Kallikrein-like Activity Of -Y-globulinsmentioning

confidence: 99%

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Presence of Kallikrein in the Γ‐globulin Permeability Factor of Guinea‐pig Serum

Davies¹,

Lowe²

1963

British Journal of Pharmacology and Chemotherapy

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y-Globulin fractions isolated from guinea-pig serum by chromatography on diethylaminoethyl cellulose exhibited all the properties of kallikrein. From a range of amino acid esters tested, only esters of arginine and lysine were hydrolysed; the esterase and capillary permeability-increasing activities of different samples were correlated. Both esterase and permeability-increasing activities could be increased by the addition of certain albumin-rich fractions or of glass beads previously treated with guinea-pig serum.

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Section: Methodsmentioning

confidence: 99%

Section: Kallikrein-like Activity Of -Y-globulinsmentioning

confidence: 99%

Presence of Kallikrein in the Γ‐globulin Permeability Factor of Guinea‐pig Serum

Davies¹,

Lowe²

1963

British Journal of Pharmacology and Chemotherapy

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“…In one, plasma was treated with ellagic add to activate its Hageman factor. Hageman factor is believed to activate kallikrein from its precursor in plasma, and this enzyme then releases polypeptide k]nlns from their precursor in plasma (29). The test mixtures consisted of 0.2 ml each of plasma and ellagic add (or barbital saline buffer), 0.04 ml of 0.1 ~ trisodium ethylenedi-mlnetetraacetic acid (NavHEDTA, pH 7.0), 0.16 ml of barbital saline buffer, and 0.1 ml of C'1 esterase inhibitor (or 0.005 M phosphate buffer).…”

Section: Serum Ctl Esterase Ini:llt~itormentioning

confidence: 99%

THE INHIBITION OF PLASMIN, PLASMA KALLIKREIN, PLASMA PERMEABILITY FACTOR, AND THE C'1r SUBCOMPONENT OF THE FIRST COMPONENT OF COMPLEMENT BY SERUM C'1 ESTERASE INHIBITOR

Ratnoff

Pensky

Ogston

et al. 1969

The Journal of Experimental Medicine

318

102

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The fraction of human serum designated as C'1 esterase inhibitor is known to inhibit the action of C'1 esterase, a plasma kallikrein, and PF/Dil, an enzyme in plasma enhancing cutaneous vascular permeability. In the present study, C'1 esterase inhibitor has been found to block the actions of plasmin and the C'1r subcomponent of the first component of complement, and to retard the generation of PF/Dil. No inhibition of blood clotting or of the generation of plasmin was demonstrable.

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“…Exposure of human plasma to glass, kaolin, celite, or other negatively charged surfaces initiates contact activation reactions that trigger the intrinsic coagulation pathway (1, .2), the kinin-forming pathway (3), and the fibrinolytic pathway (4,5). Proteins that are known to be involved in contact activation of human plasma include Hageman factor (HF, blood coagulation Factor XII) (6), plasma prekallikrein (Fletcher factor) (7,8), coagulation Factor XI (plasma thromboplastin antecedent) (9), and high molecular weight (Mr) kininogen, which was recognized in studies.of Flaujeac trait (10), Fitzgerald trait (11,12), Williams trait (13), and "contact activation cofactor" (14).…”

mentioning

confidence: 99%

Role of surface in surface-dependent activation of Hageman factor (blood coagulation Factor XII)

Griffin

1978

Proc. Natl. Acad. Sci. U.S.A.

243

143

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The mechanism by which negatively charged substances such as celite, kaolin, or ellagic acid contribute to the surface-dependent activation of Hageman factor (Factor XII) was studied. Kinetic studies of the proteolytic activation of '514-labeled human Hageman factor by human plasma kallikrein, plasmin, activated Factor XI, and trypsin were performed in the presence and absence of hig molecular, weight kininogen and surface materials such as celite, kaolin, or ellagic acid. The results showed that surface-bound Hageman factor was 500 times more susceptible than soluble Hageman factor to proteolytic activation by kallikrein in the presence of high molecular weight kininogen. Surface binding of Hageman factor enhanced its cleavage by plasmin, activated Factor XI, and trypsin by 100-fold, 30-fold, and 5-fold, respectively. On a molar basis, trypsin was twice as potent as kallikrein in the cleavage of the surface-bound Hageman factor, while plasmin and activated Factor XI were an order of magnitude less potent than kallikrein. Kallikrein even at concentrations as low as 0.5 nM (i.e., 1/1000th of the concentration of prekallikrein' in plasma) was very potent in the limited proteolysis of the surface-boulid Hageman factor. These results suggest that substances classically known as "activating surfaces" promote the activation of Hageman factor indirectly by alerng its structure such that it is much more susceptible to proteolytic activation by otherplasma or cellular proteases.

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Activation of plasma by contact with glass: evidence for a common reaction which releases plasma kinin and initiates coagulation

Cited by 249 publications

References 18 publications

Presence of Kallikrein in the Γ‐globulin Permeability Factor of Guinea‐pig Serum

Presence of Kallikrein in the Γ‐globulin Permeability Factor of Guinea‐pig Serum

THE INHIBITION OF PLASMIN, PLASMA KALLIKREIN, PLASMA PERMEABILITY FACTOR, AND THE C'1r SUBCOMPONENT OF THE FIRST COMPONENT OF COMPLEMENT BY SERUM C'1 ESTERASE INHIBITOR

Role of surface in surface-dependent activation of Hageman factor (blood coagulation Factor XII)

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