Activation of phosphoinositide 3-kinase delta by antipsychotic drugs: Preliminary results

Karbownik, Michał Seweryn; Gunerka, Paweł; Turowski, Paweł; Wieczorek, Maciej; Kowalczyk, Edward; Łężak, Wojciech; Pietras, Tadeusz

doi:10.1016/j.pharep.2017.09.005

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2021

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“…In a study exploring the use of decreased total serum globulins as a surrogate marker for hypogammaglobulinaemia, 4 of 32 primary care patients found to be hypogammaglobulinaemic Our report is the fi rst demonstration in England that clozapine-treated patients do present to specialist immunology There is evidence that the therapeutic effect of clozapine might depend on interaction with phosphatidylinositol-3kinase (PI3K) pathways [6][7][8]. Furthermore, PI3K signalling pathways are essential for the development and homeostasis of B cells [9,10].…”

Section: Discussionmentioning

confidence: 87%

First case series of clozapine induced hypogammaglobulinaemia in England

Elkhalifa¹,

Garcez²,

Drinkwater³

et al. 2021

Ann Psychiatry Treatm

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Evidence is emerging that clozapine can adversely affect immunoglobulin levels. We present a case series of 17 clozapine-treated patients referred to clinical immunology centres in the north west of England with otherwise-unexplained hypogammaglobulinaemia. This adds to existing evidence and suggests that clozapine can cause clinically signifi cant antibody defi ciency that will sometimes require specialist intervention. We speculate that this putative drug toxicity could be mediated via interaction with PI3K (phosphatidylinositol-3-kinase) signalling pathways involved in the development and homeostasis of B cells. It may be advisable to monitor immunoglobulin levels in patients being treated with clozapine.

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