Activation of phasic pontine‐wave generator in the rat: a mechanism for expression of plasticity‐related genes and proteins in the dorsal hippocampus and amygdala

Datta, Subimal; Li, Guangmu; Auerbach, Sanford

doi:10.1111/j.1460-9568.2008.06166.x

Cited by 91 publications

(80 citation statements)

References 98 publications

(172 reference statements)

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“…P wave density in REM sleep was found to be proportional to the changes in task performance after sleep [53,54]. P waves were shown to play a role in information processing after fearful experiences [54]. There are also reports on the association of P waves with the HC and Amyg during REM sleep for memory consolidation [14].…”

Section: Discussionmentioning

confidence: 98%

“…The P waves, along with the theta waves, are implicated in REM sleep dependent memory consolidation [52]. P wave density in REM sleep was found to be proportional to the changes in task performance after sleep [53,54]. P waves were shown to play a role in information processing after fearful experiences [54].…”

Section: Discussionmentioning

confidence: 99%

“…The neural connectivity of pons with HPC, Amyg and PFC may be essential for regulation of neuronal circuits associated with sleep-related functions [52,54,60]. Impairments in performance after sleep loss could be attributed to the changes in functional connectivity in various neural networks [61,62] and it could also be due to neurons going offline at local level [63].…”

Section: Discussionmentioning

confidence: 99%

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Reduced Theta Coherence and P Wave Ratio Linked to Memory Deficits After Sleep Deprivation in Rat Model

2017

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Purpose It is well established that loss of sleep leads to lapses in learning and memory. The brain regions including hippocampus, amygdala and the prefrontal cortex are associated with memory processes. However, there are not many studies on the changes in neuronal communications between these brain areas during sleep deprivation. Methods In this study, changes in the P waves, and theta coherence among the hippocampus, amygdala and the prefrontal cortex, were studied before and after exposing the animals to total sleep deprivation of 24 h. Changes in reference and working memory were evaluated after sleep deprivation.Results Concomitant with a rebound increase in non-REM sleep after total sleep deprivation, there was a decrease in the coherence of theta waves between all the studied areas, especially between hippocampus and amygdala. The ratio of P wave cluster to singlet was reduced. There was a decrease in 'correct memory performance' after sleep deprivation. Conclusions This study showed that after sleep deprivation, there was a correlation in the cognitive deficits and decrease in the coherence of theta waves, and the ratio of P wave cluster to singlet. Impairments in brain function, especially cognition, after sleep loss could be attributed to changes in functional connectivity between these neural networks. This study highlighted important functions of sleep in maintaining an appropriate synchrony between various neuronal networks during REM sleep.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Reduced Theta Coherence and P Wave Ratio Linked to Memory Deficits After Sleep Deprivation in Rat Model

2017

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“…By contrast, the pharmacological induction of pontine waves (by microinfusion of carbachol) enhanced subsequent performance to the avoidance task. These effects appear to be related to the activation of glutamatergic neurotransmission, gene expression and protein synthesis in the hippocampus and the amygdala [130]. Accordingly, synaptic transmission and late-LTP in the rat hippocampus are positively correlated with REMS quantities [131].…”

Section: Rems and Pontine Wavesmentioning

confidence: 93%

Contribution of sleep to memory consolidation

Bourdiec¹,

Muto²,

Mascetti³

et al. 2009

Future Neurol.

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A growing body of evidence indicates that sleep promotes memory consolidation; the protracted process by which fresh, labile memories are reorganized into stable memories [1]. Although the first evidence for this effect was collected more than a century ago [2], the potential underlying neural mechanisms are only just beginning to be conceptualized and characterized experimentally.Memory consolidation is a hackneyed expression that may take different meanings. At the cellular level, consolidation is often framed in terms of long-term experience-dependent changes in neural responsiveness, usually resulting from modifications in synaptic strength (Figure 1) [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. At the systems level, consolidation relates to the progressive reorganization of memories within brain circuits [20][21]. From a behavioral perspective, consolidation refers to an improvement of performance between practice sessions or a reduction of vulnerability of a memory trace after the acquisition of a novel skill [22][23], although other phenomena such as automatization [24][25] or generalization [26] might also be considered as behavioral markers of memory consolidation (Figure 1).It is therefore not surprising that the effects of sleep on memory consolidation were reported at various levels of description. The early studies assessed the effects of sleep on different memory systems at the behavioral level. They contrasted the influence of non-rapid eye movement sleep (NREMS) with rapid eye movement sleep (REMS) on declarative and procedural memories, respectively. As the understanding of the effects of sleep on memory consolidation progressed, the hypotheses were increasingly framed in terms of the neural processes occurring during NREMS or REMS, and specifically, those associated with phasic events such as slow waves, spindles or phasic REMS. This paper is organized into five sections. The first section summarizes the key findings of behavioral studies that suggest an effect of sleep on memory. Earlier reviews have already covered these results in detail [27][28][29][30][31]. The present article highlights recent data that call for a reappraisal of these effects that, although indisputable, seem quantitatively modest. The article also emphasizes the higher sensitivity of neuroimaging and neurophysiological measures in characterizing the effects of sleep on memory. The following sections review the two main hypotheses that are currently being tested, namely the homeostatic synaptic downscaling and the sleep-dependent systems-level consolidation. The final two sections emphasize the intervention of post-training REMs and wakefulness in memory processing. Behavioral effectsThe recognition of different memory systems helped to characterize the effects of sleep on memory consolidation (Figure 2). On the procedural side, spontaneous gains in performance in a motor sequence learning task were observed between initial training and later testing, specifically if the interval included sleep rather ...

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“…Although we do not know the precise reason for development of such inverse relationship between muscle activities in evolution, based on our hypothesis it may be safe to propose that the REMs probably play an important physiological role and that could be visual memory consolidation. This view may be supported by the fact that during REMS ponto-geniculo-occipital (PGO) waves are expressed in association with REMs (Conduit, Crewther, & Coleman, 2004) and expressions of PGO waves have been correlated with memory processing (Datta, 2000Datta, Li, & Auerbach, 2008. However, Pontine-waves (P-waves) (the pontine component of ponto-geniculooccipital waves) can be involved in numerous significant brain functions, such as memory consolidation as well as development of the hippocampus, amygdala and visual system (Dang-Vu, Desseilles, Peigneux, & Maquet, 2006Frank, Issa, & Stryker, 2001Datta, 2006Guzman-Marin & McGinty, 2006.…”

Section: Rems Associated Muscle Atoniamentioning

confidence: 99%

Activation of Retinotopic Visual Areas Is Central to REM Sleep Associated Dreams: Visual Dreams and Visual Imagery Possibly Co-Emerged In Evolution

Bókkon

Mallick

2012

Act Nerv Super

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The latest experimental results support that multiple retinotopic visual systems play a central role not only in the processing of visual signals but also in the integration and processing of internally represented auditory and tactile information. These retinotopic maps have access to higher levels of cognitive processing, performed by the frontal lobes, for example. The occipital cortex may have a special role in multisensory integration. There is a functional basis for the development and maturation of visual memory in association of rapid eye movement sleep (REMS) which is linked to dreams and visual imagery. Physiological and psychological processes of REMS are similar to waking visual imagery. Furthermore, visual imagery during REMS utilize a common visual neural pathway similar to that used in wakefulness. This pathway subserves visual processes accompanied with auditory experiences and intrinsic feelings. We argue that the activation of the retinotopic visual areas is central to REM sleep associated dreams and that REMS associated dreaming and visual imagery may have coevolved in homeothermic animals during evolution. We also suggest that protoconscious state during REM sleep, as introduced by Hobson many years ago, may be a basic visual process.

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Activation of phasic pontine‐wave generator in the rat: a mechanism for expression of plasticity‐related genes and proteins in the dorsal hippocampus and amygdala

Cited by 91 publications

References 98 publications

Reduced Theta Coherence and P Wave Ratio Linked to Memory Deficits After Sleep Deprivation in Rat Model

Reduced Theta Coherence and P Wave Ratio Linked to Memory Deficits After Sleep Deprivation in Rat Model

Contribution of sleep to memory consolidation

Activation of Retinotopic Visual Areas Is Central to REM Sleep Associated Dreams: Visual Dreams and Visual Imagery Possibly Co-Emerged In Evolution

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