Although photocatalysis has been proved to be a promising technology in solving various environmental problems, the preparation of visible light-driven photocatalysts on a large scale in a simple and sustainable manner still remains a technical challenge. Here, we demonstrate a simple one-pot method for the large-scale synthesis of a novel Bi 2 O 3 /TiO 2 visible light-driven photocatalyst by coupling low-cost TiO 2 with strong visible-light absorption of Bi 2 O 3 . The as-synthesized Bi 2 O 3 /TiO 2 photocatalyst exhibits efficient charge separation due to the formation of a p−n heterojunction. Additionally, the porous nanostructure of Bi 2 O 3 /TiO 2 provides high surface area and abundant active sites, realizing the complete degradation (100%) of tetracyclines under visible light (λ > 420 nm), which successfully breaks through the bottleneck of incomplete degradation of tetracyclines under visible light irradiation for most of the reported photocatalysts. Notably, since our method is based on the one-pot synthesis without any pretreatment procedure for the precursors of Bi 2 O 3 and TiO 2 , it is very suitable for the development of large-scale synthesis by using a big reactor, producing up to 23.9 g of Bi 2 O 3 /TiO 2 nanocatalyst in a single synthesis, which indicates its considerable potential for further scaleup production. Therefore, this study opens a new window for the large-scale synthesis of other visible light-driven photocatalysts with excellent photocatalytic performances.