2005
DOI: 10.1038/sj.bjc.6602851
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Activation of nuclear factor-κB in human prostate carcinogenesis and association to biochemical relapse

Abstract: Nuclear factor (NF)-kB/p65 regulates the transcription of a wide variety of genes involved in cell survival, invasion and metastasis. We characterised by immunohistochemistry the expression of NF-kB/p65 protein in six histologically normal prostate, 13 high-grade prostatic intraepithelial neoplasia (PIN) and 86 prostate adenocarcinoma specimens. Nuclear localisation of p65 was used as a measure of NF-kB active state. Nuclear localisation of NF-kB was only seen in scattered basal cells in normal prostate glands… Show more

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Cited by 111 publications
(103 citation statements)
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“…Although our study did not investigate the potential causal relationship between NF-kB activation and EMT, this last phenomenon was found to be highly relevant in resistance to therapy. Moreover, increased nuclear NF-kB (RELA staining) correlated with a shorter time to clinical relapse, confirming the prognostic value of this pathway activation in prostate cancer (22).…”
Section: Discussionmentioning
confidence: 65%
“…Although our study did not investigate the potential causal relationship between NF-kB activation and EMT, this last phenomenon was found to be highly relevant in resistance to therapy. Moreover, increased nuclear NF-kB (RELA staining) correlated with a shorter time to clinical relapse, confirming the prognostic value of this pathway activation in prostate cancer (22).…”
Section: Discussionmentioning
confidence: 65%
“…Constitutive activity of NF-kB has been reported in CaP cell lines and/or biopsy tissue and is associated with regulating the expression of genes that induce cell proliferation and/or underpin cell survival (Huang et al, 2001;Fradet et al, 2004;Ross et al, 2004;Shukla et al, 2004;Sweeney et al, 2004;Domingo-Domenech et al, 2005). However, despite suppressing the constitutive activity of the NF-kB transcription factor, DEX administration failed to reduce the proliferation or the viability of PC3 tumour cells or hBMECs.…”
Section: Discussionmentioning
confidence: 89%
“…Constitutive activation of the NF-kB transcription factor has been reported in CaP and is associated with disease progression, chemoresistance, angiogenesis and metastasis (Huang et al, 2001;Fradet et al, 2004;Ross et al, 2004;Shukla et al, 2004;Sweeney et al, 2004;Domingo-Domenech et al, 2005). Nuclear factor-kB has been reported to induce the transcription of proinflammatory genes, many of which have been implicated in each of the above phenotypes.…”
Section: Effect Of Dex On Basal Nf-jb Activity In Pc3 Cellsmentioning
confidence: 99%
“…Although the percentage of positive nuclear staining in tumor specimens varied between 15-54.7% in different studies (Lessard et al, 2003;Ross et al, 2004;Domingo-Domenech et al, 2005;Lessard et al, 2005), emerging data suggest NF-kB nuclear localization links to poor clinical outcome (Lessard et al, 2003;Ayala et al, 2004;Fradet et al, 2004). In particular, constitutive NF-kB activity correlates with progression to bone metastasis (Lessard et al, 2003).…”
Section: Yc-1 Reduced Hif-1 In Pc-3 Cells H-l Sun Et Almentioning
confidence: 99%