Activation of Notch1 signaling in stromal fibroblasts inhibits melanoma growth by upregulating WISP-1

Shao, Hongwei; Cai, Lei; Grichnik, James M.; As, Livingstone; Oc, Velazquez; Liu, Z-J

doi:10.1038/onc.2011.142

Cited by 55 publications

(84 citation statements)

References 40 publications

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“…These results suggest that the paracrine interactions may have a positive regulatory effect on tumor growth and progression. In contrast, Shao et al (2011) show that WISP1 expression is stronger in quiescent fibroblasts compared with melanoma cells and "melanoma activated fibroblasts", which suggest a negative regulatory effect of paracrine WISP1 signaling in melanoma.…”

Section: Expression In Cancer and Role In Prognosismentioning

confidence: 67%

“…Mouse melanoma cells expressing a high level of WISP1 showed slightly slower in vitro and in vivo growth rates than cells expressing a low level of the protein (Hashimoto et al, 1998). Furthermore, a recent study shows that supplementation of recombinant WISP1 (Source: mouse myeloma cells) in the culture medium has an inhibitory effect on melanoma cell growth while migration is not affected (Shao et al, 2011). The number of migrated gastric carcinoma cells (Tanaka et al, 2001) and cholangiocarcinoma cells (Tanaka et al, 2003) increased with exposure to WISP1v.…”

Section: Regulation and Biological Functionmentioning

confidence: 95%

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CCN4/WISP1 (WNT1 inducible signaling pathway protein 1): A focus on its role in cancer

Gurbuz

Chiquet‐Ehrismann

2015

The International Journal of Biochemistry & Cell Biology

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The matricellular protein WISP1 is a member of the CCN protein family. It is induced by WNT1 and is a downstream target of β-catenin. WISP1 is expressed during embryonic development, wound healing and tissue repair. Aberrant WISP1 expression is associated with various pathologies including osteoarthritis, fibrosis and cancer. Its role in tumor progression and clinical outcome makes WISP1 an emerging candidate for the detection and treatment of tumors.

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Section: Expression In Cancer and Role In Prognosismentioning

confidence: 67%

Section: Regulation and Biological Functionmentioning

confidence: 95%

CCN4/WISP1 (WNT1 inducible signaling pathway protein 1): A focus on its role in cancer

Gurbuz

Chiquet‐Ehrismann

2015

The International Journal of Biochemistry & Cell Biology

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“…37 Conversely, activation of Notch1 signalling in stromal fibroblasts can inhibit the progression of melanoma. 38 Tumour-associated fibroblasts may also modulate the host's response to antineoplastic therapy. For example, in prostate cancer, chemotherapeutic agents that damage DNA may generate a response in tumour-associated fibroblasts (and smooth muscle cells) that promote tumour growth and resistance to subsequent rounds of therapy, through a massive overproduction of WNT16B.…”

Section: Fibroblasts Fibroblastic Stroma and Desmoplasiamentioning

confidence: 99%

Is carcinoma a mesenchymal disease? The role of the stromal microenvironment in carcinogenesis

Hemmings

2013

Pathology

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“…Differential expression of CCN family members in breast cancer also has suggested that WISP1 may function to limit breast cancer growth [222]. Furthermore, Notch1 activation that results in increased WISP1 expression can suppress melanoma growth [223]. Suppression of melanoma tumor growth is lost during WISP1 gene knockdown [223].…”

Section: The Variable Impact Of Wisp1 In Tumorigenesismentioning

confidence: 99%

WISP1: Clinical Insights for a Proliferative and Restorative Member of the CCN Family

Maiese¹

2014

CNR

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As a proliferative and restorative entity, Wnt1 inducible signaling pathway protein 1 (WISP1) is emerging as a novel target for a number of therapeutic strategies that are relevant for disorders such as traumatic injury, neurodegeneration, musculoskeletal disorders, cardiovascular disease, pulmonary compromise, and control of tumor growth as well as distant metastases. WISP1, a target of the wingless pathway Wnt1, oversees cellular mechanisms that include apoptosis, autophagy, cellular migration, stem cell proliferation, angiogenesis, immune cell modulation, and tumorigenesis. The signal transduction pathways of WISP1 are broad and involve phosphoinositide 3-kinase (PI 3-K), protein kinase B (Akt), mitogen activated protein (MAP) kinase, c-Jun N-terminal kinase (JNK), caspases, forkhead transcription factors, sirtuins, c-myc, glycogen synthase kinase -3β (GSK-3β), β-catenin, miRNAs, and the mechanistic target of rapamaycin (mTOR). Ultimately, these signal transduction pathways of WISP1 can result in varied and sometimes unpredictable outcomes especially for cell survival, tissue repair, and tumorigenesis that demand increased insight into the critical role WISP1 holds for cellular biology and clinical medicine.

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Activation of Notch1 signaling in stromal fibroblasts inhibits melanoma growth by upregulating WISP-1

Cited by 55 publications

References 40 publications

CCN4/WISP1 (WNT1 inducible signaling pathway protein 1): A focus on its role in cancer

CCN4/WISP1 (WNT1 inducible signaling pathway protein 1): A focus on its role in cancer

Is carcinoma a mesenchymal disease? The role of the stromal microenvironment in carcinogenesis

WISP1: Clinical Insights for a Proliferative and Restorative Member of the CCN Family

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