Activation of NMDA receptors prevents excessive metabolic decrease in hypoxic rat pups

Baig, Mirza Shafiulla; Joseph, Vincent

doi:10.1016/j.resp.2005.06.008

Cited by 5 publications

(1 citation statement)

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“…Our protocol of neonatal hypoxic exposure was previously described (2) and presents a few particularities compared with several studies in the field. The most important is that O 2 level was set at 12% O 2 compared with 10% in other studies (6,36).…”

Section: Methodological Considerationsmentioning

confidence: 99%

Impaired acclimatization to chronic hypoxia in adult male and female rats following neonatal hypoxia

Lumbroso¹,

Joseph²

2009

American Journal of Physiology-Regulatory, Integrative and Comp

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Lumbroso D, Joseph V. Impaired acclimatization to chronic hypoxia in adult male and female rats following neonatal hypoxia. Am J Physiol Regul Integr Comp Physiol 297: R421-R427, 2009. First published June 3, 2009 doi:10.1152/ajpregu.00068.2009.-We tested the hypothesis that neonatal exposure to hypoxia alters acclimatization to chronic hypoxia later in life. Rat pups were exposed to normobaric hypoxia (12% O2; nHx group) in a sealed chamber, or to normoxia (21% O2; nNx group) from the day before birth to postnatal day 10. The animals were then raised in normal conditions until reaching 12 wk of age. At this age, we assessed ventilatory and hematological acclimatization to chronic hypoxia by exposing male and female nHx and nNx rats for 2 wk to 10% O2. Minute ventilation, metabolic rate, hypoxic ventilatory response, hematocrit, and hemoglobin levels were measured both before and after acclimatization. We also quantified right ventricular hypertrophy as an index of pulmonary hypertension both before and after acclimatization. There was a significant effect of neonatal hypoxia that decreases ventilatory response (relative to metabolic rate, V E/V CO2) to acute hypoxia before acclimatization in males but not in females. nHx rats had an impaired acclimatization to chronic hypoxia characterized by altered respiratory pattern and elevated hematocrit and hemoglobin levels after acclimatization, in both males and females. Right ventricular hypertrophy was present before and after acclimatization in nHx rats, indicating that neonatal hypoxia results in pulmonary hypertension in adults. We conclude that neonatal hypoxia impairs acclimatization to chronic hypoxia in adults and may be a factor contributing to the establishment of chronic mountain sickness in humans living at high altitude.hypoxic ventilatory acclimatization; neonatal hypoxia; chronic mountain sickness

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Section: Methodological Considerationsmentioning

confidence: 99%