Activation of NF-κB in lymphocytes and increase in serum immunoglobulin in hyperthyroidism: Possible role of oxidative stress

Nandakumar, Dalavaikodihalli Nanjaiah; Koner, Bidhan Chandra; Vinayagamoorthi, R.; Nanda, Nivedita; Negi, Vir Singh; Goswami, Kalyan; Bobby, Zachariah; Hamide, Abdoul

doi:10.1016/j.imbio.2007.10.005

Cited by 28 publications

(21 citation statements)

References 53 publications

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“…30 The results of the present study regarding hypergammablobulinemia in hyperythyroid group are consistent with results reported recently by Nandakumar et al 31 The hypergammablobulinemia in hyperythyroid patients has been associated with the activation of NF-kB in B lymphocytes through oxidative stress induced by thyroid hormones. 31 It has been also reported that higher levels of sCD23 in patients with hyperthyroidism can be attributed to generalized B-cell activation. 32 In the present study, higher serum IgE levels were observed in hypo-and hyperthyroid subjects.…”

Section: Discussionsupporting

confidence: 93%

Immunological and hematological changes in patients with hyperthyroidism or hypothyroidism

Jafarzadeh¹,

Poorgholami²,

Izadi³

et al. 2010

CIM

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Aims: Thyroid hormones have been shown to influence the immune system and haematopoiesis. The aim of this study was to evaluate some immunological and hematological parameters in peripheral blood of hypo-or hyperthyroid women. Materials and Methods: Blood samples were collected from 50 women with hypothyroid disease, 50 women with hyperthyroid disease and a control group consisting of 50 sex -and age -matched euthyroid subjects. Thyroid function assesed according to measurent of T3, T4 and TSH levels. The complete blood count (CBC), total and differential counts of white blood cells (WBC), serum levels of immunoglobulins (IgG, IgA, IgM and IgE) and C3 and C4 complement components determined in three groups by using standard immunological and hematological methods. Results: In hyperthyroid women the mean serum concentrations of IgG (2312.4±584 mg/dl), IgA (296± 87 mg/dl) and IgE ( 301± 264 IU/ml) were significantly higher than those found in the control group (1539± 974 mg/dl, P<0.0003; 234± 116 mg/dl, P<0.01; 109.8±115 IU/ml, P<0.0001, respectively) and the mean MCV was significantly lower in comparison with the euthyroid group (P<0.05). Hypothyroid patients had higher serum IgE concentrations in comparison with the euthyroid group (179.8± 218 IU/ml vs. 109.8± 115 IU/ml; P<0.047). The mean serum C3 concentration in hypothyroid patients was also significantly higher in comparison with the euthyroid group (138.7± 36.6 mg/ml vs. 117.8± 32.1 mg/dl; P<0.01). In the hypothyroid group the mean eosinophil count was markedly higher in comparison with the hyperthyroid group (P<0.06) and the mean count of RBC and the levels of some RBC-related indices, such as hematocrit and hemoglobin, were significantly lower in comparison with the euthyroid group (P<0.05). Conclusion:These results indicate hypergammablobulinemia and lower MVC in hyperythyroid patients, and higher IgE levels, C3 levels and eosinophil count as well as anemia in hypothyroid patients.

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Section: Discussionsupporting

confidence: 93%

Immunological and hematological changes in patients with hyperthyroidism or hypothyroidism

Jafarzadeh¹,

Poorgholami²,

Izadi³

et al. 2010

CIM

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“…In agreement with these views, IR-induced (1) drastic enhancement in liver oxidative 1) drastic enhancement in liver oxidative ) drastic enhancement in liver oxidative stress status and TNF-α response; (�) loss of DNA bind-; (�) loss of DNA bind-(�) loss of DNA bind-�) loss of DNA bind-) loss of DNA binding capacity of NF-κB and STAT3, implying loss of cytoprotective potential; and (�) major increment in hepatic ; and (�) major increment in hepatic and (�) major increment in hepatic �) major increment in hepatic ) major increment in hepatic AP-1 activation, which constitutes a crucial determinant of hepatotoxicity under conditions of reduced NF-κB activation and enhanced TNF-α response, are normalized by T� treatment [26] . Similar T� actions involving other physiological functions have been described, including (1) 1) ) NF-κB activation in lymphocytes from thyroxin-treated rats [45] or hyperthyroid patients [46] in association with higher oxidative stress status and potentiation of humoral immune response; and (�) JNK/STAT3 activation by T ; and (�) JNK/STAT3 activation by T and (�) JNK/STAT3 activation by T �) JNK/STAT3 activation by T ) JNK/STAT3 activation by T� in a nutritional model of non-alcoholic steatosis in rats, with complete regression of fat accumulation [47] .…”

Section: Preconditioningsupporting

confidence: 56%

Recent advances in liver preconditioning: Thyroid hormone, n-3 long-chain polyunsaturated fatty acids and iron

Fernández

Tapia²,

Videla³

2012

WJH

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Liver preconditioning (PC), defined as an enhanced tolerance to injuring stimuli induced by previous specific maneuvers triggering beneficial functional and molecular changes, is of crucial importance in human liver transplantation and major hepatic resection. For these reasons, numerous PC strategies have been evaluated in experimental models of ischemia-reperfusion liver injury, which have not been transferred to clinical application due to side effects, toxicity and difficulties in implementation, with the exception of the controversial ischemic PC. In recent years, our group has undertaken the assessment of alternate experimental liver PC protocols that might have application in the clinical setting. These include thyroid hormone (T3), n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA), or iron, which suppressed liver damage due to the 1 h ischemia-20 h reperfusion protocol. T3, n-3 LCPUFA and iron are hormetic agents that trigger biologically beneficial effects in the low-dose range, whose multifactorial mechanisms of action are discussed in the work.

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“…NF-kB) activated by oxidative stress (Nandakumar et al 2008;Morgan & Liu 2011). Based upon a variety of studies, it appears that female hosts tend to have stronger anti-oxidant defense responses than their male counterparts (Borras et al 2003;Badeau et al 2005;Vina et al 2011;Mancini et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Sex-based differences in lymphocyte proliferation in the spleen after vanadium inhalation

Rodríguez-Lara

Cambas

Villalva

et al. 2016

Journal of Immunotoxicology

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Vanadium (V) is a transition metal often adhered to particulate matter and released into the atmosphere as vanadium pentoxide (V 2 O 5 ) by the burning of fossil fuels. This air pollutant causes adverse effects in the immune system. Lymphocytosis and splenomegaly have been reported with increased white pulp in mice after V inhalation. The effect of V on the immune system as related to sex has been poorly investigated. This study sought to determine if V inhalation (a) produced lymphoproliferation that could explain the changes previously observed in the spleen and in peripheral blood lymphocyte counts and (b) whether any observed effects differed due to gender. Immunohistochemical analyses of Ki-67, a specific proliferation marker, was made in the spleens of CD-1 male and female mice exposed for 1 h, twice a week, over a 12-week period to V 2 O 5 (at 1.4 mg V 2 O 5 /m 3 ) by whole-body inhalation; similar analyses were performed on spleens of control mice exposed to vehicle (filtered air). The results showed that in male mice there was a significant increase in percentage of Ki-67 immunopositive lymphocytes starting from the second week and until the end of the exposure. The Ki-67 signal was cytoplasmic and nuclear in the exposed males, while in controls the signal was only nuclear. In female mice, V inhalation singificantly increased the percentage of proliferating lymphocytes only after 1 week of exposure. Ki-67 signal was observed only in the nucleus of lymphocytes from the control and exposed females. The results here help to explain the splenomegaly and lymphocytosis observed previously in male mice and support the lymphoproliferative effect induced by V. Lastly, the finding that there was a sex difference in the effect of vanadium on lymphocyte proliferation suggests a role for sex hormones in potential protection against V immunotoxicity; however, further studies are needed to support this hypothesis. ARTICLE HISTORY

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Activation of NF-κB in lymphocytes and increase in serum immunoglobulin in hyperthyroidism: Possible role of oxidative stress

Cited by 28 publications

References 53 publications

Immunological and hematological changes in patients with hyperthyroidism or hypothyroidism

Immunological and hematological changes in patients with hyperthyroidism or hypothyroidism

Recent advances in liver preconditioning: Thyroid hormone, n-3 long-chain polyunsaturated fatty acids and iron

Sex-based differences in lymphocyte proliferation in the spleen after vanadium inhalation

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