Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF)

Vancauwenberghe, Eric; Noyer, Lucile; Derouiche, Sandra; Lemonnier, Loïc; Gosset, Pierre; Sadofsky, Laura R.; Mariot, Pascal; Warnier, Marine; Bokhobza, Alexandre; Slomianny, Christian; Mauroy, Brigitte; Bonnal, J; Dewailly, Etienne; Delcourt, Philippe; Allart, Laurent; Desruelles, Emilie; Prevarskaya, Natalia; Roudbaraki, Morad

doi:10.1002/mc.22642

Cited by 42 publications

(35 citation statements)

References 50 publications

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“…In prostate cancer-associated fibroblasts, activation of TRPA1 leads to increased Ca 2+ levels and elevated hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) secretion. Co-cultured prostate cancer cells are rescued from apoptosis by TRPA1 activation [ 174 ].…”

Section: Influence Of the Tumor Microenvironment On Trp Channelsmentioning

confidence: 99%

The Role of TRP Channels in the Metastatic Cascade

Fels¹,

Bulk²,

Pethő³

et al. 2018

Pharmaceuticals

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A dysregulated cellular Ca2+ homeostasis is involved in multiple pathologies including cancer. Changes in Ca2+ signaling caused by altered fluxes through ion channels and transporters (the transportome) are involved in all steps of the metastatic cascade. Cancer cells thereby “re-program” and “misuse” the cellular transportome to regulate proliferation, apoptosis, metabolism, growth factor signaling, migration and invasion. Cancer cells use their transportome to cope with diverse environmental challenges during the metastatic cascade, like hypoxic, acidic and mechanical cues. Hence, ion channels and transporters are key modulators of cancer progression. This review focuses on the role of transient receptor potential (TRP) channels in the metastatic cascade. After briefly introducing the role of the transportome in cancer, we discuss TRP channel functions in cancer cell migration. We highlight the role of TRP channels in sensing and transmitting cues from the tumor microenvironment and discuss their role in cancer cell invasion. We identify open questions concerning the role of TRP channels in circulating tumor cells and in the processes of intra- and extravasation of tumor cells. We emphasize the importance of TRP channels in different steps of cancer metastasis and propose cancer-specific TRP channel blockade as a therapeutic option in cancer treatment.

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Section: Influence Of the Tumor Microenvironment On Trp Channelsmentioning

confidence: 99%

The Role of TRP Channels in the Metastatic Cascade

Fels¹,

Bulk²,

Pethő³

et al. 2018

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…Prostate cancer-derived CAFs express and have functional TRPA1 channels. Moreover, studies with the TRPA1 inhibitor HC-030031 (at a relatively high concentration of 50 µM) in a CAF and prostate cancer cell (LNCaP) coculture suggest a role for TRPA1 in regulating apoptotic sensitivity to resveratrol (Vancauwenberghe et al 2017).…”

Section: The Tumor Microenvironment and The Calcium Signalmentioning

confidence: 99%

The Calcium-Signaling Toolkit in Cancer: Remodeling and Targeting

Roberts‐Thomson

Chalmers

Monteith

2019

Cold Spring Harb Perspect Biol

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Processes that are important in cancer progression, such as sustained cell growth, invasion to other organs, and resistance to cell death inducers, have a clear overlap with pathways regulated by Ca 2+ signaling. It is therefore not surprising that proteins important in Ca 2+ signaling, sometimes referred to as the "Ca 2+ signaling toolkit," can contribute to cancer cell proliferation and invasiveness, and the ability of agents to induce cancer cell death. Ca 2+ signaling is also critical in other aspects of cancer progression, including events in the tumor microenvironment and processes involved in the acquisition of resistance to anticancer therapies. This review will consider the role of Ca 2+ signaling in tumor progression and highlight areas in which a better understanding of the interplay between the Ca 2+ -signaling toolkit and tumorigenesis is still required.

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“…Treatment with TRPA1 inhibitor (HC-030031) on PS30 abolished expression and secretion of VEGF and HGF increased by resveratrol. In the co-culture model of human prostate cancer cells (LNCaP cells) and PS30 cells, inhibition of TRPA1 by its inhibitor (HC-030031) sensitized LNCaP cells to resveratrol, shown by the increased apoptotic cell death rate [103]. Therefore, resveratrol could be used as a nutraceutical targeting CAF-enriched tumor microenvironment to increase the efficacy of other chemotherapeutic agents.…”

Section: Modulation Of Non-cancer Cells In the Tumor Microenvironmmentioning

confidence: 99%

Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer

Han

Cho

et al. 2019

IJMS

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Tumor-suppressive effects of resveratrol have been shown in various types of cancer. However, regulation of tumor microenvironment by resveratrol is still unclear. Recent findings suggest resveratrol can potentiate its tumor-suppressive effect through modulation of the signaling pathways of cellular components (fibroblasts, macrophages and T cells). Also, studies have shown that resveratrol can suppress malignant phenotypes of cancer cells acquired in response to stresses of the tumor microenvironment, such as hypoxia, oxidative stress and inflammation. We discuss the effects of resveratrol on cancer cells in stress environment of tumors as well as interactions between cancer cells and non-cancer cells in this review.

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Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF)

Cited by 42 publications

References 50 publications

The Role of TRP Channels in the Metastatic Cascade

The Role of TRP Channels in the Metastatic Cascade

The Calcium-Signaling Toolkit in Cancer: Remodeling and Targeting

Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer

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