Activation of Monocytic Cells Through Fcγ Receptors Induces the Expression of Macrophage-Inflammatory Protein (MIP)-1α, MIP-1β, and RANTES

Fernández, Nieves; Renedo, Marta; García-Rodríguez, Carmen; Crespo, Mariano Sánchez

doi:10.4049/jimmunol.169.6.3321

Cited by 67 publications

(55 citation statements)

References 45 publications

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“…The hypochlesterolemic action of SO may also be due to the high polyunsaturated fat content in the oil (Sowmya et al 2009). Another mechanism of sesamin for the hypo-cholesterolemic effect is believed to be related to the inhibition of intestinal absorption of cholesterol, increased excretion of cholesterol into bile, and decreased activity of 3-hydroxy-3-methylglutaryl coenzyme-A reductase (Chen et al 2005), which in all seemed of importance for maintaining bone health (Fernandez et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Role of phytoestrogenic oils in alleviating osteoporosis associated with ovariectomy in rats

2012

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The objective of this study was to elucidate the effect of soybean oil (SbO) and sesame oil (SO) supplemented diets on bone biomarkers changes in OVX (ovariectomized) rats. The current data exhibited significant decrease in BMD (bone mineral density), accompanied with marked depletion in the level of Ca, P and Mg in both serum and bone of OVX rats. Also, serum estrogen, total protein, HDL-C (high density lipoprotein cholesterol), bone NO levels were decreased in OVX rats. However, a significant increase in the level of serum TL (total lipids), TC (total cholesterol), TG (triglycerides), LDL-C (low density lipoprotein cholesterol), VLDL-C (very low density lipoprotein cholesterol), urine minerals (Ca, P, Mg), as well as serum, bone and urine ALP (alkaline phosphatase) and ACP (acid phosphatase) activity were recorded in OVX rats. Further changes were also detected by the increased level of urine hydroxyproline, serum parathyroid hormone and osteocalcin, as well as urea and creatinine level in both serum and urine. On the other hand, when OVX rats were fed on SbO (soy bean oil) (15 % w/w) or SO (sesame oil) (10 % w/w) supplemented diets, the data recorded a significant improvement in all the above mentioned parameters. So, it can be concluded that consumption of SbO or SO supplemented diets might be considered as a functional food for retarding risks of osteoporosis associated with estrogen deficiency in OVX states.

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Section: Discussionmentioning

confidence: 99%

Role of phytoestrogenic oils in alleviating osteoporosis associated with ovariectomy in rats

2012

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“…Fc␥Rs bind IgG or immune complexes and trigger phagocytosis, the release of chemokines and cytokines, ADCC, and ADCVI (11,33,34). Fc␥RIIa is found on several cell types involved in HIV infection, including monocytes, macrophages, and dendritic cells.…”

Section: Discussionmentioning

confidence: 99%

Recombinant gp120 Vaccine-Induced Antibodies Inhibit Clinical Strains of HIV-1 in the Presence of Fc Receptor-Bearing Effector Cells and Correlate Inversely with HIV Infection Rate

Forthal

Gilbert

Landucci

et al. 2007

The Journal of Immunology

163

159

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Nonneutralizing Abs may play a role in protecting animals and humans from lentiviral infections. We explored the Ab-dependent, cell-mediated virus inhibition (ADCVI) Ab response to recombinant gp120 (rgp120) vaccination in sera from 530 participants in the Vax 004 trial. Serum ADCVI activity was measured against a clinical R5 strain of HIV-1 using peripheral blood mononuclear effector cells from healthy donors. The level of vaccine-induced ADCVI activity correlated inversely with the rate of acquiring HIV infection following vaccination, such that for every 10% increase in ADCVI activity, there was a 6.3% decrease in the hazard rate of infection (p = 0.019). Some vaccinated individuals also mounted an ADCVI response against two other clinical R5 strains of HIV-1. However, ADCVI activity correlated poorly with neutralizing or CD4-gp120-blocking Ab activity measured against laboratory strains. Finally, the degree to which the ADCVI Ab response predicted the rate of infection was influenced by polymorphisms at the FcγRIIa and FcγRIIIa gene loci. These data indicate that rgp120 vaccination can elicit Abs with antiviral activity against clinical strains of HIV-1. However, such activity requires the presence of FcR-bearing effector cells. Our results provide further evidence that ADCVI may play a role in preventing HIV infection.

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“…2B). mRNA expression of MIP-1␣, MIP-1␤, and IL-8 was only partially sensitive to CsA, suggesting that NFAT is not the main regulator of their gene expression in this cell type, and that other transcription factors, such as C/EBP␤ or NF-B, might be involved (30). Triflusal treatment also resulted in partial inhibition of RANTES, MIP-1␣, MIP-1␤, and IL-8 expression, whereas aspirin and sodium salicylate showed weak or no inhibition (Fig.…”

Section: Inhibition Of Cytokine Gene Expression By Salicylatesmentioning

confidence: 99%

A New Pharmacological Effect of Salicylates: Inhibition of NFAT-Dependent Transcription

Aceves

Dueñas

Gómez

et al. 2004

The Journal of Immunology

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The anti-inflammatory effects of salicylates, originally attributed to inhibition of cyclooxygenase activity, are currently known to involve additional mechanisms. In this study we investigated the possible modulation by salicylates of NFAT-mediated transcription in lymphocytic and monocytic cell lines. RNase protection assays showed that 2-acetoxy-4-trifluoromethylbenzoic acid (triflusal) inhibited, in a dose-dependent manner, mRNA expression of several cytokine genes, most of which are NFAT-regulated and cyclosporin A (CsA)-sensitive. In Jurkat cells, the expression of IL-3, GM-CSF, TNF-α, TGF-β1, IL-2, lymphotactin, MIP-1α, and MIP-1β was inhibited to different extents. In THP-1 cells, inhibition of the expression of M-CSF, G-CSF, stem cell factor, IFN-γ, TNF-α, TGF-β1, lymphotoxin-β1, MIP-1α, MIP-1β, and IL-8 was observed. Sodium salicylate and aspirin only showed significant effects at 5 mM. The transcriptional activity of two genes that contain NFAT sites, a GM-CSF full promoter and a T cell-specific enhancer from the IL-3 locus, was also inhibited by salicylates. Transactivation experiments performed with several NFAT-dependent and AP-1-dependent reporter genes showed that triflusal strongly inhibited NFAT-dependent transcription at concentrations as low as 0.25 mM. Sodium salicylate and aspirin were less potent. The triflusal inhibitory effect was reversible and synergized with suboptimal doses of CsA. Experiments to address the mechanism of action of salicylates in the NFAT activation cascade disclosed a mechanism different from that of CsA, because salicylates inhibited DNA-binding and NFAT-mediated transactivation without affecting phosphorylation or subcellular localization of NFAT. In summary, these data describe a new pharmacological effect of salicylates as inhibitors of NFAT-dependent transcription.

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Activation of Monocytic Cells Through Fcγ Receptors Induces the Expression of Macrophage-Inflammatory Protein (MIP)-1α, MIP-1β, and RANTES

Cited by 67 publications

References 45 publications

Role of phytoestrogenic oils in alleviating osteoporosis associated with ovariectomy in rats

Role of phytoestrogenic oils in alleviating osteoporosis associated with ovariectomy in rats

Recombinant gp120 Vaccine-Induced Antibodies Inhibit Clinical Strains of HIV-1 in the Presence of Fc Receptor-Bearing Effector Cells and Correlate Inversely with HIV Infection Rate

A New Pharmacological Effect of Salicylates: Inhibition of NFAT-Dependent Transcription

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