Activation of mitosis and angiogenesis in diabetes-impaired wound healing by processed human amniotic fluid

Bazrafshan, Ameneh; Owji, Seyed Mohammad; Yazdani, Maryam; Varedi, Masoumeh

doi:10.1016/j.jss.2014.01.041

Cited by 21 publications

(21 citation statements)

References 25 publications

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“…A new area of research interest focuses on utilizing processed AF (PAF) ( 4 , 5 ). Human AF (HAF) is collected through amniocentesis or during Cesarean section.…”

Section: Amniotic Fluid-based Therapy In Neonates With Necrotizing En...mentioning

confidence: 99%

“…AF is widely used for its diagnostic purposes and is often considered as “biological waste”. However, researchers have started to elucidate the therapeutic potential of AF in in vitro and in vivo studies in animal models ( 4 , 5 ). Our intent was to identify relevant research on AF, its impact on the gastrointestinal tract (GIT) and to investigate the potential therapeutic application of AF on the development of NEC.…”

Section: Introductionmentioning

confidence: 99%

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Amniotic Fluid: A Perspective on Promising Advances in the Prevention and Treatment of Necrotizing Enterocolitis

et al. 2022

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Necrotizing enterocolitis (NEC) is a common and potentially fatal disease that typically affects preterm (PIs) and very low birth weight infants (VLBWIs). Although NEC has been extensively studied, the current therapeutic approaches are unsatisfactory. Due to the similarities in the composition between human amniotic fluid (AF) and human breast milk (BM), which plays a protective role in the development of NEC in PIs and VLBWIs, it has been postulated that AF has similar effects on the outcome of NEC and potential therapeutic implications. AF has been long used for its diagnostic purposes and is often discarded after birth as “biological waste”. However, researchers have started to elucidate its therapeutic potential. Experimental studies in animal models have shown that diseases of various organ systems can possibly benefit from AF-based therapy. Hence, we have identified three approaches which show promising results for future clinical application in the prevention and/or treatment of NEC: (1) administration of processed AF (PAF) isolated from donor mothers, (2) administration of AF stem cells (AFSCs), and (3) administration of simulated AF (SAF) formulated to mimic the composition of physiological AF. We have highlighted the most important aspects that should be taken into account to guide further research on the clinical application of AF-based therapy. We hope that this review can provide a framework to identify the challenges of AF-based therapy and help to design future studies to better evaluate AF-based approaches for the treatment and/or prevention of NEC in PIs and VLBWIs.

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“…A new area of research interest focuses on utilizing processed AF (PAF) ( 4 , 5 ). Human AF (HAF) is collected through amniocentesis or during Cesarean section.…”

Section: Amniotic Fluid-based Therapy In Neonates With Necrotizing En...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Amniotic Fluid: A Perspective on Promising Advances in the Prevention and Treatment of Necrotizing Enterocolitis

et al. 2022

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“…Furthermore, preclinical models in in vivo studies showed that the amniotic fluid facilitates the healing of burns as well as losses of cartilage, bone, tendon and nerve injuries [44,45]. The placenta is also a rich source of collagen, especially collagen type I.…”

Section: New Possibilities Of Application Of Grafts Prepared From Plamentioning

confidence: 99%

Preparation of Amniotic Membrane and It’s Application in the Treatment of Skin Loss and Lyell's Syndrome (Toxic Epidermal Necrolysis): Current State and New Opportunities

Klama-Baryła¹,

Łabuś²,

Kitala³

et al. 2017

J Clin Exp Dermatol Res

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Amniotic membrane is a good protection against bacterial infections, reduces losses of proteins, fluids and electrolytes, decreases pain from burns and accelerates healing. Due to its richness in nutrients and low immunogenicity, it is often used as a skin substitute. Human amnion may be prepared in tissue banks, as biostatic or biovital grafts. There are various methods of amniotic graft preparations developed to make them efficient in surgical treatment and prevent the risk of transmission of infectious diseases. This paper presents the current clinical application of human amnion in the treatment of skin losses, such as burns to the face and Lyell's syndrome (toxic epidermal necrolysis). It also describes new applications of fetal membranes for other diseases. Placental grafts are often an alternative therapy in the situations when standard treatment does not yield desirable effects. Such grafts are especially beneficial in comparison to many other bioactive therapies, including low cost, easy manipulation, capability of promoting cell migration and proliferation and stimulation of stem cell activity.

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“…3 Denuded amniotic membrane can provide a supportive niche for limbal epithelial progenitors, 4 and processed AF remains bioactive for the enhancement of diabetically-impaired wound healing. 5 There is growing recognition that AF is a rich source of stem cells with potential applications ranging from intestinal disease 6 and neuronal regeneration 7 to cancer therapy. 8 Tong's 1 review title may lack a sense of originality, but it is more important to be authentic.…”

Section: Dear Editormentioning

confidence: 99%

A novel function for amniotic fluid: Original or authentic?

Burns

Dominici

2014

Journal of the Chinese Medical Association

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Activation of mitosis and angiogenesis in diabetes-impaired wound healing by processed human amniotic fluid

Cited by 21 publications

References 25 publications

Amniotic Fluid: A Perspective on Promising Advances in the Prevention and Treatment of Necrotizing Enterocolitis

Amniotic Fluid: A Perspective on Promising Advances in the Prevention and Treatment of Necrotizing Enterocolitis

Preparation of Amniotic Membrane and It’s Application in the Treatment of Skin Loss and Lyell's Syndrome (Toxic Epidermal Necrolysis): Current State and New Opportunities

A novel function for amniotic fluid: Original or authentic?

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