Abstract:SynopsisActivation of the MEK pathway in MTC cells elicited similar effects of raf-1 pathway activation, resulting in cell growth suppression. Therefore, MEK may serve as a molecular target and a therapeutic strategy to treat patients with MTC.
IntroductionMedullary thyroid cancer (MTC) is a neuroendocrine (NE) tumor that arises from the parafollicular cells (C-cells) of the thyroid gland [1]. MTC accounts for 5-10% of all thyroid malignancies and responds poorly to chemotherapy [2]. Thus, the only curative … Show more
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