Activation of MAPK Kinase 9 Induces Ethylene and Camalexin Biosynthesis and Enhances Sensitivity to Salt Stress in Arabidopsis

Xu, Juan; Li, Yuan; Wang, Ying; Liu, Hongxia; Lei, Lei; Yang, Hongqiang; Liu, Guoqin; Ren, Dongtao

doi:10.1074/jbc.m801392200

Cited by 311 publications

(305 citation statements)

References 57 publications

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“…In fact, while many MAP kinases are described to be positively regulated under abiotic stresses, some MAP kinases play negative roles in stress tolerance. For example, overexpression of the MAP kinases, OsMAPK33 in rice ) and MKK9 in Arabidopsis (Xu et al 2008), results in high sensitivity of rice and Arabidopsis, respectively, to salt stress. Moreover, the inactivation of the Arabidopsis MKK9 by the insertion of transferred DNA (T-DNA) generates salt-insensitive phenotypes that germinate at up to 150 mM NaCl, with rapid induction of RD22 and RD29 stress genes (Alzwiy and Morris 2007).…”

Section: Map Kinase Complexity In Environmental Stresses' Signalingmentioning

confidence: 99%

MAPK cascades and major abiotic stresses

et al. 2014

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Plants have evolved with complex signaling circuits that operate under multiple conditions and govern numerous cellular functions. Stress signaling in plant cells is a sophisticated network composed of interacting proteins organized into tiered cascades where the function of a molecule is dependent on the interaction and the activation of another. In a linear scheme, the receptors of cell surface sense the stimuli and convey stress signals through specific pathways and downstream phosphorylation events controlled by mitogen-activated protein (MAP) kinases and second messengers, leading to appropriate adaptive responses. The specificity of the pathway is guided by scaffolding proteins and docking domains inside the interacting partners with distinctive structures and functions. The flexibility and the fine-tuned organization of the signaling molecules drive the activated MAP kinases into the appropriate location and connection to control and integrate the information flow. Here, we overview recent findings of the involvement of MAP kinases in major abiotic stresses (drought, cold and temperature fluctuations) and we shed light on the complexity and the specificity of MAP kinase signaling modules.

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Section: Map Kinase Complexity In Environmental Stresses' Signalingmentioning

confidence: 99%

MAPK cascades and major abiotic stresses

et al. 2014

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“…Several cytochrome P450 enzyme-encoding genes were coexpressed with PEN2 and PEN3 (Dataset S1), including CYP83B1 (SUR2), which is required for indole glucosinolate biosynthesis (13). Other genes include MPK3 and MKK9, which were recently shown to regulate biosynthesis of the indolic phytoalexin camalexin (19,20). Consistent with a role for the R2R3-MYB transcription factor MYB51 in regulating indole glucosinolate biosynthetic genes (21), the respective insertion lines exhibited enhanced fungal entry in conjunction with globally reduced levels of all metabolites tested (Figs.…”

Section: Identification Of Novel Genes Required For Defense Against Dmentioning

confidence: 99%

A regulon conserved in monocot and dicot plants defines a functional module in antifungal plant immunity

Humphry¹,

Bednarek²,

Kemmerling

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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At least two components that modulate plant resistance against the fungal powdery mildew disease are ancient and have been conserved since the time of the monocot-dicot split (≈200 Mya). These components are the seven transmembrane domain containing MLO/MLO2 protein and the syntaxin ROR2/PEN1, which act antagonistically and have been identified in the monocot barley (Hordeum vulgare) and the dicot Arabidopsis thaliana, respectively. Additionally, syntaxin-interacting N-ethylmaleimide sensitive factor adaptor protein receptor proteins (VAMP721/722 and SNAP33/34) as well as a myrosinase (PEN2) and an ABC transporter (PEN3) contribute to antifungal resistance in both barley and/or Arabidopsis. Here, we show that these genetically defined defense components share a similar set of coexpressed genes in the two plant species, comprising a statistically significant overrepresentation of gene products involved in regulation of transcription, posttranslational modification, and signaling. Most of the coexpressed Arabidopsis genes possess a common cis-regulatory element that may dictate their coordinated expression. We exploited gene coexpression to uncover numerous components in Arabidopsis involved in antifungal defense. Together, our data provide evidence for an evolutionarily conserved regulon composed of core components and clade/species-specific innovations that functions as a module in plant innate immunity.(co-)regulon | glucosinolate metabolism | pathogen entry | plant defense | evolution

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“…A module comprising the MAP3K MEKK1, the MAP2Ks MKK1 and MKK2, and the MAPK MPK4 (MEKK1/MKK1-MKK2/ MPK4) negatively controls defense responses (Kong et al, 2012;Rasmussen et al, 2012) by negatively regulating the expression of the MAP3K MEKK2, which triggers a salicylate (SA)-dependent autoimmunity response when the cascade is compromised (Berriri et al, 2012;Su et al, 2013). Two other modules, MEKK1-MAPKKKa/MKK4-MKK5/MPK3-MPK6 and MKK9/ MPK3-MPK6 (Xu et al, 2008), mediate the activation of defense responses, including the synthesis of ethylene and camalexin, i.e. a phytoalexin with antimicrobial activity.…”

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confidence: 99%

The Arabidopsis NUCLEUS- AND PHRAGMOPLAST-LOCALIZED KINASE1-Related Protein Kinases Are Required for Elicitor-Induced Oxidative Burst and Immunity

et al. 2014

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Plant immunity is activated through complex and cross-talking transduction pathways that include a mitogen-activated protein kinase phosphorylation cascade. Here, we have investigated the role in immunity of the Arabidopsis (Arabidopsis thaliana) gene subfamily that encodes the mitogen-activated protein triple kinases indicated as ARABIDOPSIS NUCLEUS-AND PHRAGMOPLAST-LOCALIZED KINASE1-RELATED PROTEIN KINASE1 (ANP1), ANP2, and ANP3. For this study, we used representative danger signals (elicitors) belonging to the classes of the damage-and pathogen-associated molecular patterns, i.e. oligogalacturonides, linear fragments derived from the plant cell wall homogalacturonan, and the peptide elf18 derived from the bacterial elongation factor thermo-unstable. Analyses of single and double as well as conditional triple mutants show that ANPs are required for elicitor-triggered defense responses and protection against the necrotrophic fungus Botrytis cinerea. Notably, ANPs are also required for both the elicitor-induced oxidative burst and the transduction of the hydrogen peroxide signal but not for the inhibition of auxin-induced gene expression, indicating that this response can be uncoupled from the activation of defense responses. Our findings point to ANPs as key transduction elements that coordinate damage-and pathogen-associated molecular patterntriggered immunity and orchestrate reactive oxygen species accumulation and signaling.

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Activation of MAPK Kinase 9 Induces Ethylene and Camalexin Biosynthesis and Enhances Sensitivity to Salt Stress in Arabidopsis

Cited by 311 publications

References 57 publications

MAPK cascades and major abiotic stresses

MAPK cascades and major abiotic stresses

A regulon conserved in monocot and dicot plants defines a functional module in antifungal plant immunity

The Arabidopsis NUCLEUS- AND PHRAGMOPLAST-LOCALIZED KINASE1-Related Protein Kinases Are Required for Elicitor-Induced Oxidative Burst and Immunity

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